Ariadne Genomics Inc. Cd14 ---- Lbp Lbp ---- LPS LPS Cd14 Lbp LPS ---- Ly96 Ly96 Traf6 ---- Ube2n Traf6 ---- Ube2v1 Irak1 ---- Traf6 Irak2 Irak4 ---> Irak1 Irak1 Irak4 ---- Myd88 Irak4 Myd88 Unc93b1 Myd88 ---- Tlr8 Unc93b1 ---> Tlr7 Myd88 ---- Tlr7 Myd88 ---- Tirap Myd88 ---- Tlr9 Traf6 TICAM1 ---- Traf6 Ripk1 --+> nuclear factor kappa B signaling pathway TICAM1 ---- Ticam2 Ticam2 Tradd Irak4 ---> Irak2 Ripk1 ---- Tradd Ripk1 Ripk1 ---- TICAM1 TICAM1 ---- Tlr3 TICAM1 ---- Traf3 Traf3 Tbk1 Tbk1 ---> Irf3 Tbk1 ---- Traf3 LPS ---- Tlr4 Tlr3 endocytosed_Tlr4 ---- Ticam2 flagellin ---- Tlr5 Tirap Tirap ---- Tlr6 Tirap ---- Tlr2 Tirap ---- Tlr1 Ly96 ---- Tlr4 Tlr1 ---- Tlr1, 2, 6 ligands Tlr1, 2, 6 ligands ---- Tlr2 Tlr1, 2, 6 ligands ---- Tlr6 Map3k7 --+> p38 MAPK signaling pathway Tlr4 ---> endocytosed_Tlr4 Double-stranded RNA ---- Tlr3 Map3k7 --+> c-Jun N-terminal kinases MAPK signaling pathway Map3k7 --+> nuclear factor kappa B signaling pathway Tlr7, 8, 9 ligands ---- Tlr8 Tlr7 ---- Tlr7, 8, 9 ligands Unc93b1 ---> Tlr8 Tlr8 Tlr7, 8, 9 ligands ---- Tlr9 Tlr7 Tlr9 Unc93b1 ---> Tlr9 Tlr4 Tirap ---- Tlr4 Tlr6 Tlr2 Tlr1 Tlr1 ---- Tlr2 Tlr2 ---- Tlr6 Myd88 ---- Tlr5 Tlr5 TICAM1 Ube2v1 Ube2n Traf6 --+> Map3k7 nuclear factor kappa B signaling pathway c-Jun N-terminal kinases MAPK signaling pathway p38 MAPK signaling pathway Tlr7, 8, 9 ligands Tlr1, 2, 6 ligands flagellin Double-stranded RNA Tab(s) Map3k7 Irf3 endocytosed_Tlr4