| URN | urn:agi-llid:23405 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1419 |
| Name | Dicer1 |
| Description | dicer 1, ribonuclease type III |
| Notes | This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq] |
| GO Molecular Function | ATP-dependent helicase activity |
|---|---|
| hydrolase activity | |
| nuclease activity | |
| endonuclease activity | |
| endoribonuclease activity, producing 5'-phosphomonoesters | |
| ribonuclease III activity | |
| helicase activity | |
| nucleotide binding | |
| ATP binding | |
| nucleic acid binding | |
| RNA binding | |
| miRNA binding | |
| double-stranded RNA binding | |
| metal ion binding |
| GO Cellular Component | RISC complex |
|---|---|
| cytoplasm | |
| endoplasmic reticulum-Golgi intermediate compartment | |
| cytosol | |
| growth cone | |
| axon | |
| dendrite |
| GO Biological Process | spleen development |
|---|---|
| defense response to virus | |
| cell proliferation | |
| production of siRNA involved in RNA interference | |
| production of miRNAs involved in gene silencing by miRNA | |
| pre-miRNA processing | |
| post-embryonic development | |
| multicellular organism growth | |
| stem cell maintenance | |
| positive regulation of myelination | |
| branching morphogenesis of an epithelial tube | |
| regulation of myelination | |
| peripheral nervous system myelin formation | |
| angiogenesis | |
| lung development | |
| inner ear receptor cell development | |
| cardiac muscle cell development | |
| regulation of odontogenesis of dentin-containing tooth | |
| regulation of enamel mineralization | |
| epidermis morphogenesis | |
| hair follicle morphogenesis | |
| cerebral cortex development | |
| olfactory bulb interneuron differentiation | |
| hair follicle development | |
| nerve development | |
| regulation of oligodendrocyte differentiation | |
| spinal cord motor neuron differentiation | |
| positive regulation of Schwann cell differentiation | |
| regulation of neurogenesis | |
| regulation of neuron differentiation | |
| negative regulation of glial cell proliferation | |
| negative regulation of Schwann cell proliferation | |
| neuron projection morphogenesis | |
| digestive tract development | |
| intestinal epithelial cell development | |
| embryonic limb morphogenesis | |
| embryonic hindlimb morphogenesis | |
| regulation of cell differentiation | |
| spindle assembly | |
| regulation of cell cycle | |
| zygote asymmetric cell division | |
| regulation of Notch signaling pathway | |
| gene silencing by RNA | |
| targeting of mRNA for destruction involved in RNA interference | |
| apoptotic process | |
| negative regulation of apoptotic process | |
| hair follicle cell proliferation | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of miRNA metabolic process | |
| positive regulation of gene expression | |
| negative regulation of transcription from RNA polymerase II promoter | |
| regulation of protein phosphorylation | |
| regulation of viral genome replication | |
| regulation of gene expression | |
| rRNA catabolic process | |
| RNA processing | |
| RNA phosphodiester bond hydrolysis, endonucleolytic | |
| gene expression |
| Pathway | RNA Gene Silencing |
|---|---|
| microRNA pathway | |
| microRNA pathway |
| Group | RNA gene silencing |
|---|---|
| spleen development | |
| defense response to virus | |
| cell proliferation | |
| ATP-dependent helicase activity | |
| production of siRNA involved in RNA interference | |
| production of miRNAs involved in gene silencing by miRNA | |
| pre-miRNA processing | |
| post-embryonic development | |
| multicellular organism growth | |
| stem cell maintenance | |
| positive regulation of myelination | |
| branching morphogenesis of an epithelial tube | |
| regulation of myelination | |
| peripheral nervous system myelin formation | |
| angiogenesis | |
| lung development | |
| inner ear receptor cell development | |
| cardiac muscle cell development | |
| regulation of odontogenesis of dentin-containing tooth | |
| regulation of enamel mineralization | |
| epidermis morphogenesis | |
| hair follicle morphogenesis | |
| cerebral cortex development | |
| olfactory bulb interneuron differentiation | |
| hair follicle development | |
| nerve development | |
| regulation of oligodendrocyte differentiation | |
| spinal cord motor neuron differentiation | |
| positive regulation of Schwann cell differentiation | |
| regulation of neurogenesis | |
| regulation of neuron differentiation | |
| negative regulation of glial cell proliferation | |
| negative regulation of Schwann cell proliferation | |
| neuron projection morphogenesis | |
| digestive tract development | |
| intestinal epithelial cell development | |
| embryonic limb morphogenesis | |
| embryonic hindlimb morphogenesis | |
| regulation of cell differentiation | |
| spindle assembly | |
| regulation of cell cycle | |
| zygote asymmetric cell division | |
| regulation of Notch signaling pathway | |
| gene silencing by RNA | |
| targeting of mRNA for destruction involved in RNA interference | |
| apoptotic process | |
| negative regulation of apoptotic process | |
| hair follicle cell proliferation | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of miRNA metabolic process | |
| positive regulation of gene expression | |
| negative regulation of transcription from RNA polymerase II promoter | |
| regulation of protein phosphorylation | |
| regulation of viral genome replication | |
| regulation of gene expression | |
| hydrolase activity | |
| nuclease activity | |
| endonuclease activity | |
| endoribonuclease activity, producing 5'-phosphomonoesters | |
| ribonuclease III activity | |
| helicase activity | |
| rRNA catabolic process | |
| RNA processing | |
| RNA phosphodiester bond hydrolysis, endonucleolytic | |
| gene expression | |
| nucleotide binding | |
| ATP binding | |
| nucleic acid binding | |
| RNA binding | |
| miRNA binding | |
| double-stranded RNA binding | |
| metal ion binding | |
| RISC complex | |
| cytoplasm | |
| endoplasmic reticulum-Golgi intermediate compartment | |
| cytosol | |
| growth cone | |
| axon | |
| dendrite | |
| Genes with Mutations Associated with Ovarian Cancer | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 23405 |
|---|---|
| 192119 | |
| 299284 |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0005524 |
|---|---|
| 0008026 | |
| 0003725 | |
| 0046872 | |
| 0035198 | |
| 0004525 | |
| 0001525 | |
| 0006915 | |
| 0048754 | |
| 0055013 | |
| 0021987 | |
| 0051607 | |
| 0035116 | |
| 0010467 | |
| 0071335 | |
| 0031069 | |
| 0060119 | |
| 0060576 | |
| 0030324 | |
| 0035264 | |
| 0010626 | |
| 0043066 | |
| 0000122 | |
| 0021675 | |
| 0048812 | |
| 0021889 | |
| 0032290 | |
| 0014040 | |
| 2000630 | |
| 0031643 | |
| 0045944 | |
| 0009791 | |
| 0031054 | |
| 0035196 | |
| 0030422 | |
| 0051726 | |
| 0070173 | |
| 0045664 | |
| 0048713 | |
| 0045069 | |
| 0021522 | |
| 0051225 | |
| 0048536 | |
| 0019827 | |
| 0030423 | |
| 0010070 | |
| 0016442 | |
| 0005829 | |
| 0003723 | |
| 0004519 | |
| 0016891 | |
| 0004386 | |
| 0016787 | |
| 0004518 | |
| 0003676 | |
| 0000166 | |
| 0090502 | |
| 0006396 | |
| 0008283 | |
| 0048565 | |
| 0030326 | |
| 0048730 | |
| 0031047 | |
| 0001942 | |
| 0060253 | |
| 0010628 | |
| 0016075 | |
| 0008593 | |
| 0045595 | |
| 0010468 | |
| 0031641 | |
| 0050767 | |
| 0042487 | |
| 0001932 | |
| 0030424 | |
| 0005737 | |
| 0030425 | |
| 0005793 | |
| 0030426 | |
| 0005515 | |
| 0005794 | |
| 0005622 | |
| 0005634 |
| Alias | DCR1 |
|---|---|
| MNG1 | |
| Dicer | |
| HERNA | |
| RMSE2 | |
| endoribonuclease Dicer | |
| K12H4.8-LIKE | |
| helicase MOI | |
| helicase-moi | |
| Dicer1, Dcr-1 homolog | |
| helicase with RNAse motif | |
| dicer 1, double-stranded RNA-specific endoribonuclease | |
| D12Ertd7e | |
| mKIAA0928 | |
| 1110006F08Rik | |
| double-strand-specific ribonuclease mDCR-1 | |
| KIAA0928 | |
| homolog of Dicer | |
| homolog of Drosophila Dicer | |
| LOC217855 | |
| dicer enzyme | |
| ribonuclease dicer | |
| RIKEN cDNA 1110006F08 gene | |
| dicer ribonuclease | |
| 1110006F08 | |
| dicer 1, ribonuclease type III | |
| DICER I | |
| DICER1 | |
| Dicer1, Dcr-1 homolog (Drosophila) | |
| DNA segment, Chr 12, ERATO Doi 7, expressed | |
| homolog of Dicer | |
| DICER1s |
| Mouse chromosome position | 12 54.83 cM |
|---|---|
| 12 51.0 cM |
| OMIM ID | 606241 |
|---|---|
| 138800 | |
| 601200 | |
| 180295 |
| Rat chromosome position | 6q32 |
|---|
| Hugo ID | 17098 |
|---|
| Human chromosome position | 14q32.13 |
|---|
| Swiss-Prot Accession | Q9UPY3 |
|---|---|
| F8VQ54 | |
| Q8R418 | |
| A7E2D3 | |
| E0AD28 | |
| O95943 | |
| Q9UQ02 | |
| Q5D0K4 | |
| Q5D0K5 | |
| Q9UFF3 | |
| Q05CY3 | |
| Q3UUV8 | |
| Q6P8L5 | |
| Q6ZQ23 | |
| Q8CBU8 | |
| Q8R419 | |
| Q4G034 |
| Unigene ID | Hs.87889 |
|---|---|
| Mm.21135 | |
| Rn.205881 |
| KEGG ID | hsa:23405 |
|---|---|
| mmu:192119 | |
| rno:299284 |
| Swiss-Prot ID | DICER_HUMAN |
|---|---|
| A7E2D3_HUMAN |
| EC Number | 3.1.26.- |
|---|---|
| 3.1.26.3 |
| Ensembl ID | ENSG00000100697 |
|---|---|
| ENSP00000435681 | |
| ENST00000527414 | |
| ENSP00000376783 | |
| ENST00000393063 | |
| ENSP00000343745 | |
| ENST00000343455 | |
| ENSMUSG00000041415 | |
| ENSMUSP00000043676 | |
| ENSMUST00000041987 |
| Homologene ID | 13251 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 2177178 |
|---|
| RGD ID | 1309381 |
|---|
| MedScan ID | 23405 |
|---|
| IPI ID | IPI00219036 |
|---|---|
| IPI00227881 | |
| IPI00365891 |