| URN | urn:agi-llid:26981 |
|---|---|
| Total Entities | 0 |
| Connectivity | 204 |
| Name | Pabpc1 |
| Description | poly(A) binding protein, cytoplasmic 1 |
| Notes | This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.[provided by RefSeq, Aug 2010] |
| GO Molecular Function | translation activator activity |
|---|---|
| protein C-terminus binding | |
| nucleotide binding | |
| nucleic acid binding | |
| RNA binding | |
| poly(A) binding | |
| poly(U) RNA binding | |
| mRNA binding |
| GO Cellular Component | spliceosomal complex |
|---|---|
| catalytic step 2 spliceosome | |
| ribonucleoprotein complex | |
| cytoplasmic stress granule | |
| cytoplasm | |
| cytosol | |
| nucleus |
| GO Biological Process | gene silencing by RNA |
|---|---|
| positive regulation of nuclear-transcribed mRNA poly(A) tail shortening | |
| positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | |
| positive regulation of translation | |
| negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | |
| mRNA stabilization | |
| translational initiation | |
| nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | |
| nuclear-transcribed mRNA poly(A) tail shortening | |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | |
| RNA metabolic process | |
| mRNA metabolic process | |
| RNA splicing | |
| mRNA processing | |
| mRNA splicing, via spliceosome | |
| mRNA polyadenylation | |
| cellular protein metabolic process | |
| translation | |
| gene expression |
| Pathway | Translation |
|---|---|
| mRNA Degradation | |
| Preconditioning Ischemia | |
| microRNA pathway |
| Group | mRNA processing |
|---|---|
| gene silencing by RNA | |
| positive regulation of nuclear-transcribed mRNA poly(A) tail shortening | |
| positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | |
| positive regulation of translation | |
| translation activator activity | |
| negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | |
| mRNA stabilization | |
| translational initiation | |
| nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | |
| nuclear-transcribed mRNA poly(A) tail shortening | |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | |
| RNA metabolic process | |
| mRNA metabolic process | |
| RNA splicing | |
| mRNA processing | |
| mRNA splicing, via spliceosome | |
| mRNA polyadenylation | |
| cellular protein metabolic process | |
| translation | |
| gene expression | |
| protein C-terminus binding | |
| nucleotide binding | |
| nucleic acid binding | |
| RNA binding | |
| poly(A) binding | |
| poly(U) RNA binding | |
| mRNA binding | |
| spliceosomal complex | |
| catalytic step 2 spliceosome | |
| ribonucleoprotein complex | |
| cytoplasmic stress granule | |
| cytoplasm | |
| cytosol | |
| nucleus |
| LocusLink ID | 26981 |
|---|---|
| 26986 | |
| 18458 | |
| 171350 |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm |
| GO ID | 0000166 |
|---|---|
| 0008143 | |
| 0008022 | |
| 0008494 | |
| 0016070 | |
| 0044267 | |
| 0010467 | |
| 0031047 | |
| 0016071 | |
| 0006378 | |
| 0000398 | |
| 0048255 | |
| 2000623 | |
| 0000288 | |
| 0000184 | |
| 0000289 | |
| 1900153 | |
| 0060213 | |
| 0045727 | |
| 0006412 | |
| 0006413 | |
| 0071013 | |
| 0005737 | |
| 0010494 | |
| 0005829 | |
| 0005634 | |
| 0030529 | |
| 0003723 | |
| 0003729 | |
| 0003676 | |
| 0008266 | |
| 0008380 | |
| 0006397 | |
| 0005681 |
| Alias | PAB1 |
|---|---|
| PABP | |
| PABP1 | |
| PABPC2 | |
| PABPL1 | |
| polyadenylate-binding protein 1 | |
| poly(A) binding protein, cytoplasmic 2 | |
| ePAB | |
| PabpI | |
| PABP-1 | |
| poly A binding protein 1 | |
| poly(A)-binding protein 1 | |
| PABP 1 | |
| Poly(A)-binding protein I | |
| poly(A) binding protein, cytoplasmic I | |
| poly(A) binding protein, cytoplasmic 1 | |
| Polyadenylate-binding protein I | |
| PABPC1 | |
| MGC91496 | |
| poly(A) binding protein, cytoplasmic II | |
| PAB I | |
| PABP I | |
| 4932702K14 | |
| PABP+ | |
| Pabpc I | |
| OTTMUSP00000021349 |
| Mouse chromosome position | 15 |
|---|
| OMIM ID | 604679 |
|---|
| Rat chromosome position | 7q22 |
|---|
| Hugo ID | 8554 |
|---|
| Human chromosome position | 8q22.2-q23 |
|---|
| Swiss-Prot Accession | P11940 |
|---|---|
| E7EQV3 | |
| E7ERJ7 | |
| P29341 | |
| Q9EPH8 | |
| Q15097 | |
| Q93004 | |
| Q99L36 |
| PIR ID | A93668 |
|---|---|
| S52491 | |
| I48718 |
| Unigene ID | Hs.387804 |
|---|---|
| Mm.371570 | |
| Rn.127813 |
| KEGG ID | hsa:26986 |
|---|---|
| mmu:18458 | |
| rno:171350 |
| Swiss-Prot ID | PABP1_HUMAN |
|---|---|
| PABP1_RAT | |
| PABP1_MOUSE |
| Ensembl ID | ENSG00000070756 |
|---|---|
| ENSP00000313007 | |
| ENST00000318607 | |
| ENSP00000429594 | |
| ENST00000519004 | |
| ENSMUSG00000022283 | |
| ENSMUSP00000001809 | |
| ENSMUST00000001809 |
| Homologene ID | 37638 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1349722 |
|---|
| RGD ID | 619838 |
|---|
| MedScan ID | 26981 |
|---|