| URN | urn:agi-llid:104 |
|---|---|
| Total Entities | 0 |
| Connectivity | 167 |
| Name | Adarb1 |
| Description | adenosine deaminase, RNA-specific, B1 |
| Notes | This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | hydrolase activity |
|---|---|
| adenosine deaminase activity | |
| double-stranded RNA adenosine deaminase activity | |
| RNA binding | |
| double-stranded RNA binding | |
| mRNA binding | |
| metal ion binding |
| GO Cellular Component | nucleoplasm |
|---|---|
| nucleolus | |
| nucleus |
| GO Biological Process | defense response to virus |
|---|---|
| innate immune response | |
| regulation of cell cycle | |
| negative regulation of cell migration | |
| negative regulation of cell proliferation | |
| positive regulation of viral genome replication | |
| negative regulation of protein kinase activity by regulation of protein phosphorylation | |
| RNA processing | |
| mRNA modification | |
| base conversion or substitution editing | |
| adenosine to inosine editing | |
| mRNA processing | |
| gene expression |
| Pathway | Proteins Involved in Pathogenesis of Amyotrophic Lateral Sclerosis |
|---|---|
| Dysregulation of RNA and DNA Metabolism in Amyotrophic Lateral Sclerosis | |
| microRNA pathway |
| Group | mRNA processing |
|---|---|
| defense response to virus | |
| innate immune response | |
| regulation of cell cycle | |
| negative regulation of cell migration | |
| negative regulation of cell proliferation | |
| positive regulation of viral genome replication | |
| negative regulation of protein kinase activity by regulation of protein phosphorylation | |
| hydrolase activity | |
| adenosine deaminase activity | |
| double-stranded RNA adenosine deaminase activity | |
| RNA processing | |
| mRNA modification | |
| base conversion or substitution editing | |
| adenosine to inosine editing | |
| mRNA processing | |
| gene expression | |
| RNA binding | |
| double-stranded RNA binding | |
| mRNA binding | |
| metal ion binding | |
| nucleoplasm | |
| nucleolus | |
| nucleus | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 104 |
|---|---|
| 110532 | |
| 25367 |
| Cell Localization | Nucleus |
|---|---|
| Nucleolus |
| GO ID | 0003723 |
|---|---|
| 0004000 | |
| 0003726 | |
| 0003725 | |
| 0003729 | |
| 0046872 | |
| 0006396 | |
| 0006382 | |
| 0016553 | |
| 0051607 | |
| 0010467 | |
| 0045087 | |
| 0016556 | |
| 0006397 | |
| 0030336 | |
| 0008285 | |
| 0044387 | |
| 0045070 | |
| 0051726 | |
| 0005730 | |
| 0005654 | |
| 0005634 | |
| 0016787 |
| Alias | RED1 |
|---|---|
| ADAR2 | |
| DRABA2 | |
| DRADA2 | |
| double-stranded RNA-specific editase 1 | |
| RNA editase | |
| RED1 homolog | |
| RNA-editing enzyme 1 | |
| RNA editing deaminase 1 | |
| RNA-editing deaminase 1 | |
| dsRNA adenosine deaminase DRADA2 | |
| adenosine deaminase, RNA-specific, B1 (RED1 homolog rat) | |
| adenosine deaminase, RNA-specific, B1 (homolog of rat RED1) | |
| AW124433 | |
| AW558573 | |
| BB220382 | |
| D10Bwg0447e | |
| 1700057H01Rik | |
| dsRNA adenosine deaminase | |
| RNA editing deaminase of glutamate receptors | |
| OTTHUMP00000115342 | |
| OTTMUSP00000022332 | |
| OTTMUSP00000022333 | |
| OTTMUSP00000022335 | |
| editases | |
| OTTMUSP00000022336 | |
| OTTMUSP00000022334 | |
| OTTHUMP00000115341 | |
| human dsRNA adenosine deaminase DRADA2b | |
| hRED1 | |
| editase | |
| dsRNA adenosine deaminase 2 | |
| OTTMUSP00000022337 | |
| human dsRNA adenosine deaminase DRADA2 | |
| RED I | |
| RNA editing enzyme 1 | |
| RNA editing enzyme I | |
| RNA-specific adenosine deaminase B1 | |
| RNA-specific adenosine deaminase B1 isoform DRADA2a | |
| RNA-specific adenosine deaminase B1 isoform DRADA2c | |
| RIKEN cDNA 1700057H01 gene | |
| RNA-specific adenosine deaminase B1 isoform DRABA2b | |
| ADAR2c | |
| ADAR2a | |
| 1700057H01 | |
| ADAR2a-L1 | |
| ADAR2a-L2 | |
| ADAR2b | |
| ADAR2c ADAR2d | |
| ADAR2d | |
| ADAR2g | |
| Adarb I | |
| Adarb1 | |
| adenosine deaminase acting on RNA type2a | |
| ADAR2a-L3 | |
| Double-stranded RNA-specific editase I | |
| adenosine deaminase acting on RNA type2d | |
| DNA segment, Chr 10, Brigham & Women's Genetics 0447 expressed | |
| adenosine deaminase, RNA-specific, B1 | |
| adenosine deaminase, RNA-specific, B | |
| adenosine deaminase acting on RNA type2g |
| Mouse chromosome position | 10 39.72 cM |
|---|
| OMIM ID | 601218 |
|---|
| Rat chromosome position | 20p12 |
|---|
| Hugo ID | 226 |
|---|
| Human chromosome position | 21q22.3 |
|---|
| Swiss-Prot Accession | P78563 |
|---|---|
| Q4AE77 | |
| Q91ZS8 | |
| P51400 | |
| C3TTQ1 | |
| Q3UHM7 | |
| Q8K3X1 | |
| Q91ZS6 | |
| Q91ZS7 | |
| Q91ZS9 | |
| Q99MU8 | |
| A6NFK8 | |
| A6NJ84 | |
| O00395 | |
| O00465 | |
| O00691 | |
| O00692 | |
| P78555 | |
| Q4AE79 | |
| Q8NFD1 |
| PIR ID | S68443 |
|---|
| Unigene ID | Hs.474018 |
|---|---|
| Mm.276815 | |
| Rn.89675 | |
| Rn.172406 |
| KEGG ID | hsa:104 |
|---|---|
| mmu:110532 | |
| rno:25367 |
| Swiss-Prot ID | RED1_MOUSE |
|---|---|
| RED1_RAT | |
| RED1_HUMAN |
| EC Number | 3.5.4.37 |
|---|
| Ensembl ID | ENSG00000197381 |
|---|---|
| ENSP00000015877 | |
| ENST00000348831 | |
| ENSP00000441897 | |
| ENST00000539173 | |
| ENSP00000374513 | |
| ENST00000389863 | |
| ENSMUSG00000020262 | |
| ENSMUSP00000095976 | |
| ENSMUST00000098374 | |
| ENSMUSP00000020496 | |
| ENSMUST00000020496 | |
| ENSRNOG00000001227 | |
| ENSRNOP00000001642 | |
| ENSRNOT00000001642 |
| Homologene ID | 8280 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 891999 |
|---|
| RGD ID | 2033 |
|---|
| MedScan ID | 104 |
|---|