| URN | urn:agi-llid:54464 |
|---|---|
| Total Entities | 0 |
| Connectivity | 59 |
| Name | Xrn1 |
| Description | 5'-3' exoribonuclease 1 |
| Notes | This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] |
| GO Molecular Function | hydrolase activity |
|---|---|
| nuclease activity | |
| exonuclease activity | |
| 5'-3' exoribonuclease activity | |
| 5'-3' exonuclease activity | |
| nucleic acid binding | |
| RNA binding | |
| DNA binding |
| GO Cellular Component | cytoplasmic mRNA processing body |
|---|---|
| intracellular | |
| plasma membrane | |
| cytoplasm | |
| Golgi apparatus | |
| cytosol | |
| intermediate filament cytoskeleton |
| GO Biological Process | meiotic nuclear division |
|---|---|
| telomere maintenance | |
| cell aging | |
| nuclear-transcribed mRNA catabolic process | |
| histone mRNA catabolic process | |
| nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | |
| nuclear mRNA surveillance | |
| exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | |
| rRNA catabolic process | |
| RNA metabolic process | |
| RNA processing | |
| mRNA metabolic process | |
| RNA phosphodiester bond hydrolysis, exonucleolytic | |
| gene expression |
| Pathway | mRNA Degradation |
|---|---|
| microRNA pathway |
| Group | RNA degradation |
|---|---|
| meiotic nuclear division | |
| telomere maintenance | |
| cell aging | |
| hydrolase activity | |
| nuclease activity | |
| exonuclease activity | |
| 5'-3' exoribonuclease activity | |
| 5'-3' exonuclease activity | |
| nuclear-transcribed mRNA catabolic process | |
| histone mRNA catabolic process | |
| nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | |
| nuclear mRNA surveillance | |
| exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | |
| rRNA catabolic process | |
| RNA metabolic process | |
| RNA processing | |
| mRNA metabolic process | |
| RNA phosphodiester bond hydrolysis, exonucleolytic | |
| gene expression | |
| nucleic acid binding | |
| RNA binding | |
| DNA binding | |
| cytoplasmic mRNA processing body | |
| intracellular | |
| plasma membrane | |
| cytoplasm | |
| Golgi apparatus | |
| cytosol | |
| intermediate filament cytoskeleton |
| LocusLink ID | 54464 |
|---|---|
| 24127 | |
| 300944 |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0008409 |
|---|---|
| 0003677 | |
| 0003723 | |
| 0016070 | |
| 0043928 | |
| 0010467 | |
| 0071044 | |
| 0016071 | |
| 0071028 | |
| 0000956 | |
| 0000288 | |
| 0016075 | |
| 0005794 | |
| 0005737 | |
| 0000932 | |
| 0005829 | |
| 0045111 | |
| 0005886 | |
| 0004534 | |
| 0004527 | |
| 0016787 | |
| 0004518 | |
| 0003676 | |
| 0090503 | |
| 0006396 | |
| 0007569 | |
| 0007126 | |
| 0000723 | |
| 0005622 |
| Alias | SEP1 |
|---|---|
| 5'-3' exoribonuclease 1 | |
| strand-exchange protein 1 homolog | |
| exo | |
| Dhm2 | |
| mXrn1 | |
| protein Dhm2 | |
| RGD1309713 | |
| mXrn I | |
| XRN I | |
| XRN1 | |
| strand-exchange protein I | |
| strand-exchange protein 1 | |
| OTTHUMP00000214578 | |
| 5'-3' exoribonuclease I | |
| C78334 | |
| DKFZp434P0721 | |
| DKFZp686B22225 | |
| DKFZp686F19113 | |
| exoribonuclease, variant 1 | |
| exoribonuclease, variant I | |
| FLJ41903 |
| Mouse chromosome position | 9 |
|---|
| OMIM ID | 607994 |
|---|
| Rat chromosome position | 8q31 |
|---|
| Hugo ID | 30654 |
|---|
| Human chromosome position | 3q23 |
|---|
| Swiss-Prot Accession | Q8IZH2 |
|---|---|
| F8VQ87 | |
| P97789 | |
| O35651 | |
| P97790 | |
| Q3TE44 | |
| Q3TRE9 | |
| Q3UQL5 | |
| Q4G0S3 | |
| Q68D88 | |
| Q6AI24 | |
| Q6MZS8 | |
| Q86WS7 | |
| Q8N8U4 | |
| Q9UF39 |
| PIR ID | T30174 |
|---|---|
| T30175 | |
| T30244 | |
| T43461 |
| Unigene ID | Hs.435103 |
|---|---|
| Mm.291179 | |
| Mm.436819 | |
| Rn.13214 |
| KEGG ID | hsa:54464 |
|---|---|
| mmu:24127 | |
| rno:300944 |
| Swiss-Prot ID | XRN1_MOUSE |
|---|---|
| XRN1_HUMAN |
| EC Number | 3.1.13.- |
|---|
| Ensembl ID | ENSG00000114127 |
|---|---|
| ENSP00000264951 | |
| ENST00000264951 | |
| ENSMUSG00000032410 | |
| ENSMUSP00000034981 | |
| ENSMUST00000034981 |
| Homologene ID | 5894 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 891964 |
|---|
| RGD ID | 1309713 |
|---|
| MedScan ID | 54464 |
|---|