Protein Tarbp2

URN	urn:agi-llid:6895
Total Entities	0
Connectivity	83
Name	Tarbp2
Description	TAR (HIV-1) RNA binding protein 2
Notes	HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene. [provided by RefSeq]

GO Molecular Function	protein homodimerization activity
	RNA binding
	siRNA binding
	miRNA binding
	double-stranded RNA binding

GO Cellular Component	RISC complex
	cytoplasm
	cytosol
	perinuclear region of cytoplasm
	nucleus

GO Biological Process	negative regulation of defense response to virus by host
	production of siRNA involved in RNA interference
	pre-miRNA processing
	gene silencing by RNA
	targeting of mRNA for destruction involved in RNA interference
	miRNA loading onto RISC involved in gene silencing by miRNA
	positive regulation of viral genome replication
	negative regulation of protein kinase activity
	regulation of translation
	regulation of viral transcription
	regulation of transcription, DNA-templated
	regulation of transcription from RNA polymerase II promoter
	gene expression

Group	Polymerase II transcription
	negative regulation of defense response to virus by host
	production of siRNA involved in RNA interference
	pre-miRNA processing
	gene silencing by RNA
	targeting of mRNA for destruction involved in RNA interference
	miRNA loading onto RISC involved in gene silencing by miRNA
	positive regulation of viral genome replication
	negative regulation of protein kinase activity
	regulation of translation
	regulation of viral transcription
	regulation of transcription, DNA-templated
	regulation of transcription from RNA polymerase II promoter
	gene expression
	protein homodimerization activity
	RNA binding
	siRNA binding
	miRNA binding
	double-stranded RNA binding
	RISC complex
	cytoplasm
	cytosol
	perinuclear region of cytoplasm
	nucleus

Alias	LOQS
	TRBP
	TRBP1
	TRBP2
	RISC-loading complex subunit TARBP2
	TAR RNA binding protein 2
	TAR RNA-binding protein 2
	TAR (HIV) RNA binding protein 2
	TAR (HIV) RNA-binding protein 2
	TAR (HIV) RNA-binding protein TRBP1
	trans-activation responsive RNA-binding protein
	trans-activation-responsive RNA-binding protein
	Prbp
	PRM-1 RNA-binding protein
	protamine-1 RNA-binding protein
	Tarbp2
	TAR RNA-binding protein II
	tar rna-binding protein trbp1
	Trans-activating responsive RNA-binding protein
	TAR RNA binding protein 2 isoform c
	TAR RNA binding protein-2
	TAR RNA-binding protein-2
	TAR RNA binding protein 2 isoform b
	OTTMUSP00000045239
	TAR RNA binding protein 2 isoform a
	MGC124970
	OTTMUSP00000045240
	TAR (HIV) RNA binding protein II
	TAR (HIV-1) RNA binding protein 2
	Trans-activating responsive RNA-binding protein
	Trans-activation responsive RNA-binding protein
	Tarbp2s

Mouse chromosome position	15 57.65 cM
	15 61.7 cM

OMIM ID	605053

Rat chromosome position	7q36

Hugo ID	11569

Human chromosome position	12q13.13
	12q12-q13

PIR ID	G01420

Homologene ID	7562

MGI ID	103027

RGD ID	1307375

MedScan ID	6895