| URN | urn:agi-llid:54487 |
|---|---|
| Total Entities | 0 |
| Connectivity | 178 |
| Name | Dgcr8 |
| Description | DiGeorge syndrome critical region gene 8 |
| Notes | This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010] |
| GO Molecular Function | RNA binding |
|---|---|
| double-stranded RNA binding | |
| metal ion binding |
| GO Cellular Component | nucleoplasm |
|---|---|
| nucleolus | |
| cytoplasm | |
| microtubule cytoskeleton | |
| nucleus |
| GO Biological Process | primary miRNA processing |
|---|---|
| gene expression |
| Pathway | RNA Gene Silencing |
|---|---|
| microRNA pathway | |
| microRNA pathway |
| Group | primary miRNA processing |
|---|---|
| gene expression | |
| RNA binding | |
| double-stranded RNA binding | |
| metal ion binding | |
| nucleoplasm | |
| nucleolus | |
| cytoplasm | |
| microtubule cytoskeleton | |
| nucleus |
| LocusLink ID | 54487 |
|---|---|
| 94223 | |
| 287954 |
| Cell Localization | Nucleus |
|---|---|
| Nucleolus |
| GO ID | 0003725 |
|---|---|
| 0046872 | |
| 0010467 | |
| 0031053 | |
| 0005737 | |
| 0015630 | |
| 0005730 | |
| 0005654 | |
| 0005634 | |
| 0003723 | |
| 0005515 | |
| 0005622 |
| Alias | Gy1 |
|---|---|
| pasha | |
| DGCRK6 | |
| C22orf12 | |
| LP4941 | |
| microprocessor complex subunit DGCR8 | |
| DiGeorge syndrome critical region 8 | |
| DiGeorge syndrome critical region gene 8 | |
| N41 | |
| D16Wis2 | |
| Vo59c07 | |
| D16H22S788E | |
| D16H22S1742E | |
| diGeorge syndrome critical region 8 homolog | |
| Gy I | |
| LOC128990 | |
| LOC200302 | |
| OTTHUMP00000197674 | |
| OTTMUSP00000027994 | |
| OTTMUSP00000027995 | |
| FLJ22127 | |
| DGCR8 microprocessor complex subunit | |
| FLJ21886 | |
| FLJ21774 | |
| DNA segment, Chr 16, human D22S1742E, expressed | |
| DiGeorge syndrome critical region gene VIII | |
| DGCR8 protein (DiGeorge syndrome critical region 8) | |
| Dgcr8 | |
| chromosome 22 open reading frame 12 |
| Mouse chromosome position | 16 11.31 cM |
|---|---|
| 16 10.9 cM |
| OMIM ID | 609030 |
|---|---|
| 192430 |
| Rat chromosome position | 11q23 |
|---|
| Hugo ID | 2847 |
|---|
| Human chromosome position | 22q11.2 |
|---|
| Swiss-Prot Accession | Q8WYQ5 |
|---|---|
| Q9EQM6 | |
| D4A2G4 | |
| B2R8G1 | |
| Q6DCB2 | |
| Q6MZE9 | |
| Q6Y2L0 | |
| Q96G39 | |
| Q96GP8 | |
| Q9H6L8 | |
| Q9H6T7 | |
| Q9NRW2 | |
| Q53GY5 |
| Unigene ID | Hs.643452 |
|---|---|
| Hs.713579 | |
| Mm.447352 | |
| Mm.482156 | |
| Rn.17134 | |
| Mm.235287 |
| KEGG ID | hsa:54487 |
|---|---|
| mmu:94223 | |
| rno:287954 |
| Swiss-Prot ID | DGCR8_HUMAN |
|---|---|
| DGCR8_MOUSE |
| Ensembl ID | ENSG00000128191 |
|---|---|
| ENSP00000372488 | |
| ENST00000383024 | |
| ENSP00000263209 | |
| ENST00000351989 | |
| ENSMUSG00000022718 | |
| ENSMUSP00000009321 | |
| ENSMUST00000009321 | |
| ENSRNOG00000001886 | |
| ENSRNOP00000002581 | |
| ENSRNOT00000002581 |
| Homologene ID | 11223 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 2151114 |
|---|
| RGD ID | 1306365 |
|---|
| MedScan ID | 54487 |
|---|
| IPI ID | IPI00165970 |
|---|---|
| IPI00216207 | |
| IPI00549380 | |
| IPI00400143 | |
| IPI00361838 |