| URN | urn:agi-llid:103 |
|---|---|
| Total Entities | 0 |
| Connectivity | 293 |
| Name | Adar |
| Description | adenosine deaminase, RNA-specific |
| Notes | This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010] |
| GO Molecular Function | hydrolase activity |
|---|---|
| adenosine deaminase activity | |
| double-stranded RNA adenosine deaminase activity | |
| RNA binding | |
| DNA binding | |
| double-stranded RNA binding | |
| left-handed Z-DNA binding | |
| metal ion binding |
| GO Cellular Component | nucleoplasm |
|---|---|
| nucleolus | |
| supraspliceosomal complex | |
| cytoplasm | |
| nucleus |
| GO Biological Process | immune system process |
|---|---|
| defense response to virus | |
| innate immune response | |
| type I interferon signaling pathway | |
| in utero embryonic development | |
| cytokine-mediated signaling pathway | |
| gene silencing by RNA | |
| negative regulation of apoptotic process | |
| protein export from nucleus | |
| protein import into nucleus | |
| response to interferon-alpha | |
| response to virus | |
| positive regulation of viral genome replication | |
| negative regulation of protein kinase activity by regulation of protein phosphorylation | |
| regulation of transcription, DNA-templated | |
| negative regulation of viral genome replication | |
| transcription, DNA-templated | |
| RNA processing | |
| mRNA modification | |
| base conversion or substitution editing | |
| adenosine to inosine editing | |
| mRNA processing | |
| gene expression |
| Pathway | microRNA pathway |
|---|
| Group | immune system process |
|---|---|
| defense response to virus | |
| innate immune response | |
| type I interferon signaling pathway | |
| in utero embryonic development | |
| cytokine-mediated signaling pathway | |
| gene silencing by RNA | |
| negative regulation of apoptotic process | |
| protein export from nucleus | |
| protein import into nucleus | |
| response to interferon-alpha | |
| response to virus | |
| positive regulation of viral genome replication | |
| negative regulation of protein kinase activity by regulation of protein phosphorylation | |
| regulation of transcription, DNA-templated | |
| negative regulation of viral genome replication | |
| hydrolase activity | |
| adenosine deaminase activity | |
| double-stranded RNA adenosine deaminase activity | |
| transcription, DNA-templated | |
| RNA processing | |
| mRNA modification | |
| base conversion or substitution editing | |
| adenosine to inosine editing | |
| mRNA processing | |
| gene expression | |
| RNA binding | |
| DNA binding | |
| double-stranded RNA binding | |
| left-handed Z-DNA binding | |
| metal ion binding | |
| nucleoplasm | |
| nucleolus | |
| supraspliceosomal complex | |
| cytoplasm | |
| nucleus |
| LocusLink ID | 103 |
|---|---|
| 56417 | |
| 81635 |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus | |
| Nucleolus |
| GO ID | 0003677 |
|---|---|
| 0003723 | |
| 0003726 | |
| 0046872 | |
| 0006382 | |
| 0016553 | |
| 0019221 | |
| 0051607 | |
| 0010467 | |
| 0031047 | |
| 0045087 | |
| 0016556 | |
| 0006397 | |
| 0043066 | |
| 0044387 | |
| 0045070 | |
| 0006611 | |
| 0006606 | |
| 0035455 | |
| 0009615 | |
| 0060337 | |
| 0005737 | |
| 0005730 | |
| 0005654 | |
| 0005634 | |
| 0044530 | |
| 0004000 | |
| 0003725 | |
| 0016787 | |
| 0003692 | |
| 0006396 | |
| 0002376 | |
| 0001701 | |
| 0045071 | |
| 0006355 | |
| 0006351 |
| Alias | DSH |
|---|---|
| AGS6 | |
| G1P1 | |
| IFI4 | |
| P136 | |
| ADAR1 | |
| DRADA | |
| DSRAD | |
| IFI-4 | |
| K88DSRBP | |
| RP11-61L14.5 | |
| double-stranded RNA-specific adenosine deaminase | |
| dsRNA adenosine deaminase | |
| interferon-induced protein 4 | |
| interferon-inducible protein 4 | |
| adenosine deaminase acting on RNA 1-A | |
| 136 kDa double-stranded RNA-binding protein | |
| mZaADAR | |
| AV242451 | |
| RNA adenosine deaminase 1 | |
| RNA-specific adenosine deaminase p110 form | |
| RNA-specific adenosine deaminase p150 form | |
| ADAR/AGS6 | |
| OTTMUSP00000032302 | |
| mZaADARs | |
| OTTHUMP00000035372 | |
| OTTMUSP00000021978 | |
| OTTMUSP00000032303 | |
| RNA-specific adenosine deaminase | |
| interferon-induced protein IV | |
| OTTHUMP00000035373 | |
| Aicardi-Goutieres syndrome 6 gene | |
| AicardiuGouti?res syndrome 6 gene | |
| ADAR I | |
| OTTMUSP00000021979 | |
| ADAR | |
| ADAR-a | |
| ADAR-b | |
| ADAR-c | |
| adenosine deaminase, RNA-specific | |
| G1P I | |
| double-stranded RNA adenosine deaminase | |
| dsRNA-adenosine deaminase | |
| 136 kDa double-stranded RNA binding protein |
| Mouse chromosome position | 3 |
|---|
| OMIM ID | 146920 |
|---|---|
| 615010 | |
| 127400 |
| Rat chromosome position | 2q34 |
|---|
| Hugo ID | 225 |
|---|
| Human chromosome position | 1q21.3 |
|---|
| Swiss-Prot Accession | P55265 |
|---|---|
| Q3UH31 | |
| Q99MU3 | |
| P55266 | |
| B1AQQ9 | |
| B1AQR0 | |
| D3DV76 | |
| O15223 | |
| O43859 | |
| O43860 | |
| Q9BYM3 | |
| Q9BYM4 | |
| O70375 | |
| Q80UZ6 | |
| Q8C222 | |
| Q99MU2 | |
| Q99MU4 | |
| Q99MU7 |
| PIR ID | S65593 |
|---|---|
| I57549 |
| Unigene ID | Hs.12341 |
|---|---|
| Mm.316628 | |
| Rn.10056 |
| KEGG ID | hsa:103 |
|---|---|
| mmu:56417 | |
| rno:81635 |
| Swiss-Prot ID | DSRAD_HUMAN |
|---|---|
| DSRAD_MOUSE | |
| DSRAD_RAT |
| EC Number | 3.5.4.37 |
|---|---|
| 3.5.4.- |
| Ensembl ID | ENSG00000160710 |
|---|---|
| ENSP00000357456 | |
| ENST00000368471 | |
| ENSP00000357459 | |
| ENST00000368474 | |
| ENSMUSG00000027951 | |
| ENSMUSP00000096525 | |
| ENSMUST00000098924 | |
| ENSMUSP00000103028 | |
| ENSMUST00000107405 |
| Homologene ID | 9281 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1889575 |
|---|
| RGD ID | 71099 |
|---|
| MedScan ID | 103 |
|---|