Protein Tarbp2

URN	urn:agi-llid:6895
Connectivity	8
Name	Tarbp2
Description	TAR (HIV-1) RNA binding protein 2
Notes	HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene. [provided by RefSeq]

Pathway	microRNA pathway
	microRNA pathway

GO Molecular Function	RNA binding
	protein homodimerization activity
	siRNA binding
	double-stranded RNA binding

GO Cellular Component	intracellular
	cytoplasm
	perinuclear region of cytoplasm
	RNA-induced silencing complex
	nucleus

GO Biological Process	negative regulation of defense response to virus by host
	gene silencing by RNA
	regulation of translation
	regulation of transcription, DNA-dependent
	regulation of viral transcription
	regulation of transcription from RNA polymerase II promoter
	negative regulation of protein kinase activity
	pre-microRNA processing
	production of siRNA involved in RNA interference
	targeting of mRNA for destruction involved in RNA interference
	miRNA loading onto RISC involved in gene silencing by miRNA
	positive regulation of viral genome replication

Ariadne Ontology	Polymerase II transcription

Group	Polymerase II transcription
	negative regulation of defense response to virus by host
	gene silencing by RNA
	regulation of translation
	regulation of transcription, DNA-dependent
	regulation of viral transcription
	regulation of transcription from RNA polymerase II promoter
	negative regulation of protein kinase activity
	pre-microRNA processing
	production of siRNA involved in RNA interference
	targeting of mRNA for destruction involved in RNA interference
	miRNA loading onto RISC involved in gene silencing by miRNA
	positive regulation of viral genome replication
	RNA binding
	protein homodimerization activity
	siRNA binding
	double-stranded RNA binding
	intracellular
	cytoplasm
	perinuclear region of cytoplasm
	RNA-induced silencing complex
	nucleus

MedScan ID	6895

Hugo ID	11569

Human chromosome position	12q12-q13

Alias	LOQS
	TRBP
	TRBP1
	TRBP2
	RISC-loading complex subunit TARBP2
	TAR RNA binding protein 2
	TAR RNA-binding protein 2
	TAR (HIV) RNA binding protein 2
	TAR (HIV) RNA-binding protein 2
	TAR (HIV) RNA-binding protein TRBP1
	trans-activation responsive RNA-binding protein
	trans-activation-responsive RNA-binding protein
	Prbp
	OTTMUSP00000045239
	OTTMUSP00000045240
	PRM-1 RNA-binding protein
	protamine-1 RNA-binding protein
	MGC124970
	TAR (HIV) RNA binding protein II
	TAR (HIV-1) RNA binding protein 2
	TAR RNA binding protein 2 isoform a
	TAR RNA binding protein 2 isoform b
	TAR RNA binding protein 2 isoform c
	TAR RNA-binding protein II
	tar rna-binding protein trbp1
	Tarbp2
	Trans-activating responsive RNA-binding protein
	Trans-activating responsive RNA-binding protein
	Trans-activation responsive RNA-binding protein
	Tarbp2s

OMIM ID	605053

Mouse chromosome position	15 61.7 cM

Rat chromosome position	7q36

PIR ID	G01420

Homologene ID	7562

RGD ID	1307375

MGI ID	103027