| URN | urn:agi-llid:29102 |
|---|---|
| Connectivity | 51 |
| Name | Rnasen |
| Description | ribonuclease type III, nuclear |
| Notes | Members of the ribonuclease III superfamily of double-stranded (ds) RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells (Fortin et al., 2002 [PubMed 12191433]). The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA) processing in the nucleus (Lee et al., 2003 [PubMed 14508493]).[supplied by OMIM] |
| Pathway | microRNA pathway |
|---|---|
| microRNA pathway |
| GO Molecular Function | hydrolase activity |
|---|---|
| RNA binding | |
| double-stranded RNA binding | |
| metal ion binding | |
| magnesium ion binding | |
| manganese ion binding | |
| nuclease activity | |
| endonuclease activity | |
| ribonuclease III activity |
| GO Cellular Component | intracellular |
|---|---|
| cytoplasm | |
| nucleolus | |
| nucleus |
| GO Biological Process | gene silencing by RNA |
|---|---|
| ribosome biogenesis | |
| RNA processing | |
| mRNA processing | |
| rRNA catabolic process | |
| rRNA processing |
| Ariadne Ontology | RNA gene silencing |
|---|
| Group | RNA gene silencing |
|---|---|
| gene silencing by RNA | |
| ribosome biogenesis | |
| RNA processing | |
| mRNA processing | |
| rRNA catabolic process | |
| rRNA processing | |
| hydrolase activity | |
| RNA binding | |
| double-stranded RNA binding | |
| metal ion binding | |
| magnesium ion binding | |
| manganese ion binding | |
| nuclease activity | |
| endonuclease activity | |
| ribonuclease III activity | |
| intracellular | |
| cytoplasm | |
| nucleolus | |
| nucleus |
| MedScan ID | 29102 |
|---|
| Hugo ID | 17904 |
|---|
| Human chromosome position | 5p13.3 |
|---|
| LocusLink ID | 29102 |
|---|---|
| 14000 | |
| 310159 |
| Alias | RN3 |
|---|---|
| DROSHA | |
| ETOHI2 | |
| RANSE3L | |
| RNASE3L | |
| HSA242976 | |
| ribonuclease 3 | |
| p241 | |
| RNase III | |
| nuclear RNase III Drosha | |
| putative ribonuclease III | |
| ribonuclease III, nuclear | |
| drosha, ribonuclease type III | |
| drosha, double-stranded RNA-specific endoribonuclease | |
| putative protein p241 which interacts with transcription factor Sp1 | |
| AI874853 | |
| MGC115770 | |
| 1110013A17Rik | |
| ethanol induced 2 | |
| OTTMUSP00000027894 | |
| RGD1307626 | |
| ribonuclease type III, nuclear | |
| 1110013A17 | |
| ethanol induced II | |
| ribonuclease III | |
| rnasen | |
| RIKEN cDNA 1110013A17 gene | |
| Etohi2s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 608828 |
|---|
| Mouse chromosome position | 15 |
|---|---|
| 15 A1 |
| GO ID | 0003725 |
|---|---|
| 0004519 | |
| 0016787 | |
| 0046872 | |
| 0004525 | |
| 0006396 | |
| 0031047 | |
| 0016075 | |
| 0042254 | |
| 0005622 | |
| 0005730 | |
| 0005634 | |
| 0003723 | |
| 0004518 | |
| 0006397 | |
| 0006364 | |
| 0005737 | |
| 0000287 | |
| 0030145 | |
| 0005515 | |
| 0003674 | |
| 0008150 | |
| 0005575 |
| Rat chromosome position | 2q16 |
|---|
| Swiss-Prot Accession | Q9NRR4 |
|---|---|
| Q59FF9 | |
| Q5HZJ0 | |
| Q6PAJ6 | |
| Q6PF88 | |
| Q7TMI8 | |
| Q80UU5 | |
| Q80Z69 | |
| Q8CJ74 | |
| Q9CTG2 | |
| Q67B98 | |
| Q7Z5V2 | |
| Q86YH0 | |
| Q9NW73 | |
| Q9Y2V9 | |
| Q9Y4Y0 |
| Unigene ID | Hs.97997 |
|---|---|
| Mm.293142 | |
| Rn.41113 |
| KEGG ID | hsa:29102 |
|---|---|
| mmu:14000 | |
| rno:310159 |
| EC Number | 3.1.26.3 |
|---|
| Swiss-Prot ID | RNC_MOUSE |
|---|---|
| RNC_HUMAN | |
| Q5HZJ0_MOUSE |
| Cell Localization | Nucleus |
|---|---|
| nucleolus | |
| Cytoplasm |
| IPI ID | IPI00336345 |
|---|---|
| IPI00219990 | |
| IPI00300956 | |
| IPI00942044 | |
| IPI00515032 | |
| IPI00626208 | |
| IPI00559397 | |
| IPI00870720 |
| Homologene ID | 8293 |
|---|
| RGD ID | 1307626 |
|---|
| MGI ID | 1261425 |
|---|