Protein Ran

URN	urn:agi-llid:5901
Connectivity	125
Name	Ran
Description	RAN, member RAS oncogene family
Notes	RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq]

Pathway	microRNA pathway
	microRNA pathway

GO Molecular Function	nucleotide binding
	chromatin binding
	androgen receptor binding
	transcription coactivator activity
	GTP binding
	GTPase activity

GO Biological Process	cell division
	cell cycle
	interspecies interaction between organisms
	transport
	spermatid development
	signal transduction
	microtubule cytoskeleton organization
	mitotic spindle organization
	mitosis
	positive regulation of transcription, DNA-dependent
	DNA metabolic process
	protein transport
	intracellular protein transport
	nucleocytoplasmic transport
	protein export from nucleus
	protein import into nucleus
	RNA export from nucleus
	androgen receptor signaling pathway

Group	Nuclear export
	Protein nucleus import
	Oncogenes
	cell division
	cell cycle
	interspecies interaction between organisms
	transport
	spermatid development
	signal transduction
	microtubule cytoskeleton organization
	mitotic spindle organization
	mitosis
	positive regulation of transcription, DNA-dependent
	DNA metabolic process
	protein transport
	intracellular protein transport
	nucleocytoplasmic transport
	protein export from nucleus
	protein import into nucleus
	RNA export from nucleus
	androgen receptor signaling pathway
	nucleotide binding
	chromatin binding
	androgen receptor binding
	transcription coactivator activity
	GTP binding
	GTPase activity
	cytoplasm
	cytosol
	melanosome
	chromatin
	nucleoplasm
	nuclear pore
	nucleus

MedScan ID	5901

Hugo ID	9846

Human chromosome position	12q24.3

Alias	TC4
	Gsp1
	ARA24
	OK/SW-cl.81
	GTP-binding nuclear protein Ran
	RanGTPase
	GTPase Ran
	OTTHUMP00000166078
	OTTHUMP00000166102
	ras-like protein TC4
	member RAS oncogene family
	ras-related nuclear protein
	guanosine triphosphatase Ran
	androgen receptor-associated protein 24
	OTTMUSP00000018390
	OTTMUSP00000018391
	1700009N14
	1700009N14Rik
	1A2K_C
	1A2K_D
	1A2K_E
	androgen receptor associated protein 24
	GTP-binding nuclear protein RAN (Guillardia theta)
	GTP-binding Ran/TC4
	LOC65666
	LOC87046
	RAN
	Ran GTPase
	RAN small monomeric GTPase
	RAN small monomeric GTPases
	RAN, member RAS oncogene family
	Ran/M2
	RAN_HUMAN
	Rasl2 IX
	RASL2 VIII
	RASL2-8
	Rasl2-9
	RAS-like, family 2, locus
	RAS-like, family 2, locus 9
	Androgen receptor- associated protein 24
	RIKEN cDNA 1700009N14 gene
	Ran/M2s

OMIM ID	601179

Mouse chromosome position	5
	5 G1.3

Rat chromosome position	12q14

PIR ID	A44393

Homologene ID	68143

RGD ID	620367

MGI ID	1333112