| URN | urn:agi-llid:23405 |
|---|---|
| Connectivity | 211 |
| Name | Dicer1 |
| Description | dicer 1, ribonuclease type III |
| Notes | This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq] |
| Pathway | microRNA pathway |
|---|---|
| microRNA pathway |
| GO Molecular Function | nucleotide binding |
|---|---|
| nucleic acid binding | |
| hydrolase activity | |
| RNA binding | |
| ATP binding | |
| double-stranded RNA binding | |
| metal ion binding | |
| magnesium ion binding | |
| manganese ion binding | |
| nuclease activity | |
| endonuclease activity | |
| ribonuclease III activity | |
| helicase activity | |
| ATP-dependent helicase activity |
| GO Cellular Component | intracellular |
|---|---|
| growth cone | |
| cytoplasm | |
| ER-Golgi intermediate compartment | |
| RNA-induced silencing complex | |
| axon | |
| dendrite |
| GO Biological Process | stem cell maintenance |
|---|---|
| angiogenesis | |
| lung development | |
| cardiac muscle cell development | |
| branching morphogenesis of a tube | |
| embryonic limb morphogenesis | |
| embryonic hindlimb morphogenesis | |
| gene silencing by RNA | |
| RNA processing | |
| pre-microRNA processing | |
| production of miRNAs involved in gene silencing by miRNA | |
| production of siRNA involved in RNA interference | |
| targeting of mRNA for destruction involved in RNA interference |
| Ariadne Ontology | RNA gene silencing |
|---|
| Group | RNA gene silencing |
|---|---|
| stem cell maintenance | |
| angiogenesis | |
| lung development | |
| cardiac muscle cell development | |
| branching morphogenesis of a tube | |
| embryonic limb morphogenesis | |
| embryonic hindlimb morphogenesis | |
| gene silencing by RNA | |
| RNA processing | |
| pre-microRNA processing | |
| production of miRNAs involved in gene silencing by miRNA | |
| production of siRNA involved in RNA interference | |
| targeting of mRNA for destruction involved in RNA interference | |
| nucleotide binding | |
| nucleic acid binding | |
| hydrolase activity | |
| RNA binding | |
| ATP binding | |
| double-stranded RNA binding | |
| metal ion binding | |
| magnesium ion binding | |
| manganese ion binding | |
| nuclease activity | |
| endonuclease activity | |
| ribonuclease III activity | |
| helicase activity | |
| ATP-dependent helicase activity | |
| intracellular | |
| growth cone | |
| cytoplasm | |
| ER-Golgi intermediate compartment | |
| RNA-induced silencing complex | |
| axon | |
| dendrite |
| MedScan ID | 23405 |
|---|
| Hugo ID | 17098 |
|---|
| Human chromosome position | 14q32.13 |
|---|
| LocusLink ID | 23405 |
|---|---|
| 192119 | |
| 299284 |
| Alias | DCR1 |
|---|---|
| Dicer | |
| HERNA | |
| KIAA0928 | |
| endoribonuclease Dicer | |
| K12H4.8-LIKE | |
| helicase MOI | |
| helicase-moi | |
| Dicer1, Dcr-1 homolog | |
| helicase with RNAse motif | |
| dicer 1, double-stranded RNA-specific endoribonuclease | |
| D12Ertd7e | |
| mKIAA0928 | |
| 1110006F08Rik | |
| double-strand-specific ribonuclease mDCR-1 | |
| 1110006F08 | |
| dicer 1, ribonuclease type III | |
| DICER I | |
| DICER1 | |
| Dicer1, Dcr-1 homolog (Drosophila) | |
| DNA segment, Chr 12, ERATO Doi 7, expressed | |
| homolog of Dicer | |
| homolog of Drosophila Dicer | |
| LOC217855 | |
| homolog of Dicer | |
| RIKEN cDNA 1110006F08 gene | |
| DICER1s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 606241 |
|---|---|
| 601200 |
| Mouse chromosome position | 12 51.0 cM |
|---|
| GO ID | 0005524 |
|---|---|
| 0008026 | |
| 0003725 | |
| 0004519 | |
| 0004386 | |
| 0016787 | |
| 0046872 | |
| 0000166 | |
| 0004525 | |
| 0006396 | |
| 0001525 | |
| 0048754 | |
| 0055013 | |
| 0035116 | |
| 0031047 | |
| 0030324 | |
| 0031054 | |
| 0030422 | |
| 0019827 | |
| 0030423 | |
| 0005793 | |
| 0016442 | |
| 0030424 | |
| 0005737 | |
| 0030425 | |
| 0030426 | |
| 0005622 | |
| 0003723 | |
| 0004518 | |
| 0003676 | |
| 0030326 | |
| 0035196 | |
| 0000287 | |
| 0030145 | |
| 0005515 | |
| 0005794 | |
| 0005634 |
| Rat chromosome position | 6q32 |
|---|
| Swiss-Prot Accession | Q9UPY3 |
|---|---|
| Q5D0K4 | |
| Q5D0K5 | |
| Q9UFF3 | |
| Q05CY3 | |
| Q3UUV8 | |
| Q6P8L5 | |
| Q6ZQ23 | |
| Q8CBU8 | |
| Q8R418 | |
| Q4G034 | |
| A7E2D3 | |
| O95943 | |
| Q9UQ02 | |
| Q8R419 |
| Unigene ID | Hs.87889 |
|---|---|
| Mm.21135 | |
| Rn.19806 | |
| Rn.205881 |
| KEGG ID | hsa:23405 |
|---|---|
| mmu:192119 | |
| rno:299284 |
| EC Number | 3.1.26.- |
|---|
| Swiss-Prot ID | DICER_HUMAN |
|---|---|
| A7E2D3_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00219036 |
|---|---|
| IPI00227881 | |
| IPI00365891 |
| Homologene ID | 13251 |
|---|
| RGD ID | 1309381 |
|---|
| MGI ID | 2177178 |
|---|