Elsevier Inc. adenosine ---> inosine uridine ---> t-uridine PAN2-PAN3 complex CCR4-NOT complex DCP1-DCP2 complex Xrn1 Tnrc6 AGO AGO ---- Tnrc6 RISC complex DCP1-DCP2 complex ---- RISC complex GDP GTP t-uridine uridine inosine adenosine RISC complex --+> DCP1-DCP2 complex DCP1-DCP2 complex ---- Xrn1 Tarbp2 Dicer1 GTP ---> GDP Xpo5 Ran Drosha Zcchc6 Zcchc11 Adar Adarb1 Tnrc6 --+> CCR4-NOT complex Tnrc6 --+> PAN2-PAN3 complex Pabpc1 --+> PAN2-PAN3 complex Pabpc1 Pabpc1 ---- PAN2-PAN3 complex PAN2-PAN3 complex ---- Tnrc6 Pabpc1 ---- Tnrc6 RISC complex ---| translation pathway CCR4-NOT complex ---- Tnrc6 Ran ---- Xpo5 Dgcr8 ---- Drosha Tarbp2 --+> Dicer1 Dicer1 ---- Tarbp2 GDP ---- Ran GTP ---- Ran Dgcr8 spliceosome pathway RNA polymerase II transcription pathway translation pathway target translational repression target deadenylation target degradation target decapping