| URN | urn:agi-llid:6571 |
|---|---|
| Total Entities | 0 |
| Connectivity | 389 |
| Name | Slc18a2 |
| Description | solute carrier family 18 (vesicular monoamine transporter), member 2 |
| Notes | The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (summary by Peter et al., 1993 [PubMed 7905859]). See also SLC18A1 (MIM 193002).[supplied by OMIM, Jan 2011] |
| GO Molecular Function | serotonin transmembrane transporter activity |
|---|---|
| drug transmembrane transporter activity | |
| amine transmembrane transporter activity | |
| monoamine transmembrane transporter activity | |
| drug binding | |
| enzyme binding | |
| heat shock protein binding |
| GO Cellular Component | membrane |
|---|---|
| integral component of membrane | |
| integral component of plasma membrane | |
| clathrin-sculpted monoamine transport vesicle membrane | |
| synaptic vesicle membrane | |
| cell body | |
| plasma membrane | |
| cell projection | |
| cytoplasm | |
| cytoplasmic vesicle | |
| dense core granule | |
| synaptic vesicle | |
| axon terminus | |
| terminal bouton | |
| neuron projection | |
| neuronal cell body |
| GO Biological Process | death |
|---|---|
| post-embryonic development | |
| aging | |
| transmembrane transport | |
| synaptic transmission | |
| neurotransmitter secretion | |
| synaptic vesicle amine transport | |
| insulin secretion | |
| ion transmembrane transport | |
| monoamine transport | |
| drug transport | |
| neurotransmitter transport | |
| endocytic recycling | |
| negative regulation of neurotransmitter transport | |
| serotonin transport | |
| response to toxic substance | |
| response to drug | |
| response to cocaine | |
| response to corticosterone | |
| response to metal ion | |
| response to zinc ion | |
| cellular response to drug | |
| cellular response to ammonium ion | |
| response to amphetamine | |
| response to herbicide | |
| response to starvation | |
| locomotory behavior | |
| transport | |
| glucose homeostasis |
| Pathway | Young Onset SNCA Induced Parkinson's Disease |
|---|---|
| Proteins Involved in Pathogenesis of Parkinson's Disease | |
| Dopamine Metabolism in Parkinson's Disease | |
| Neurotoxin-Induced Parkinson's Disease | |
| GABA(B)R -> postsynaptic inhibition | |
| Nociception-related DRD2 expression targets | |
| Serotonin release cycle | |
| Epinephrine/Norepinephrine release cycle | |
| Dopamine release cycle | |
| TGFA/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| GAST Expression Targets | |
| norepinephrine biosynthetic pathway | |
| dopamine biosynthetic pathway | |
| epinephrine biosynthetic pathway |
| Group | Neurotransmitter loading |
|---|---|
| Other transport proteins | |
| death | |
| post-embryonic development | |
| aging | |
| transmembrane transport | |
| synaptic transmission | |
| neurotransmitter secretion | |
| synaptic vesicle amine transport | |
| insulin secretion | |
| ion transmembrane transport | |
| serotonin transmembrane transporter activity | |
| drug transmembrane transporter activity | |
| amine transmembrane transporter activity | |
| monoamine transmembrane transporter activity | |
| monoamine transport | |
| drug transport | |
| neurotransmitter transport | |
| endocytic recycling | |
| negative regulation of neurotransmitter transport | |
| serotonin transport | |
| response to toxic substance | |
| response to drug | |
| response to cocaine | |
| response to corticosterone | |
| response to metal ion | |
| response to zinc ion | |
| cellular response to drug | |
| cellular response to ammonium ion | |
| response to amphetamine | |
| response to herbicide | |
| response to starvation | |
| locomotory behavior | |
| transport | |
| glucose homeostasis | |
| drug binding | |
| enzyme binding | |
| heat shock protein binding | |
| membrane | |
| integral component of membrane | |
| integral component of plasma membrane | |
| clathrin-sculpted monoamine transport vesicle membrane | |
| synaptic vesicle membrane | |
| cell body | |
| plasma membrane | |
| cell projection | |
| cytoplasm | |
| cytoplasmic vesicle | |
| dense core granule | |
| synaptic vesicle | |
| axon terminus | |
| terminal bouton | |
| neuron projection | |
| neuronal cell body | |
| Secreted proteins |
| LocusLink ID | 6571 |
|---|---|
| 214084 | |
| 25549 |
| Cell Localization | Plasma membrane |
|---|---|
| Cytoplasmic vesicle membrane |
| GO ID | 0005275 |
|---|---|
| 0008144 | |
| 0019899 | |
| 0031072 | |
| 0008504 | |
| 0015222 | |
| 0007568 | |
| 0071242 | |
| 0035690 | |
| 0016265 | |
| 0032456 | |
| 0042593 | |
| 0030073 | |
| 0007626 | |
| 0015844 | |
| 0051589 | |
| 0007269 | |
| 0009791 | |
| 0001975 | |
| 0042220 | |
| 0051412 | |
| 0009635 | |
| 0042594 | |
| 0010043 | |
| 0007268 | |
| 0055085 | |
| 0070083 | |
| 0031045 | |
| 0005887 | |
| 0016020 | |
| 0043025 | |
| 0005886 | |
| 0030672 | |
| 0043195 | |
| 0015238 | |
| 0015893 | |
| 0034220 | |
| 0006836 | |
| 0009636 | |
| 0006837 | |
| 0015842 | |
| 0006810 | |
| 0043679 | |
| 0044297 | |
| 0042995 | |
| 0005737 | |
| 0031410 | |
| 0016021 | |
| 0043005 | |
| 0008021 | |
| 0042493 | |
| 0010038 |
| Alias | SVAT |
|---|---|
| SVMT | |
| VAT2 | |
| VMAT2 | |
| synaptic vesicular amine transporter | |
| monoamine transporter | |
| vesicular amine transporter 2 | |
| vesicle monoamine/H+ antiporter | |
| solute carrier family 18 member 2 | |
| vesicle monoamine transporter type 2 | |
| monoamine neurotransmitter transporter | |
| solute carrier family 18 (vesicular monoamine), member 2 | |
| 9330105E13 | |
| 1110037L13Rik | |
| vesicular monoamine transporter 2 | |
| MNAT | |
| VMAT-2 | |
| solute carrier family 18, member 2 | |
| Solute carrier family 18 A2 (vesicular monoamine transporter 2) | |
| Synaptic vesicle amine transporter | |
| vesicle monoamine transporter type II | |
| Vesicular amine transporter II | |
| RIKEN cDNA 1110037L13 gene | |
| solute carrier family 18 (vesicular monoamine transporter), member 2 | |
| vesicular monoamine transporter II | |
| solute carrier family 18, member II | |
| AV329468 | |
| MGC120477 | |
| MGC120478 | |
| MGC90556 | |
| OTTHUMP00000020576 | |
| Slc18a2 | |
| solute carrier family 18 (vesicular monoamine), member II | |
| solute carrier family 18 a2 | |
| MGC26538 | |
| 1110037L13 |
| Mouse chromosome position | 19 54.64 cM |
|---|
| OMIM ID | 193001 |
|---|
| Rat chromosome position | 1q55 |
|---|
| Hugo ID | 10935 |
|---|
| Human chromosome position | 10q25 |
|---|
| Swiss-Prot Accession | Q05940 |
|---|---|
| Q8BRU6 | |
| Q01827 | |
| Q9QVP1 | |
| Q8CC55 | |
| B2RC96 | |
| D3DRC4 | |
| Q15876 | |
| Q5VW49 | |
| Q9H3P6 |
| PIR ID | A46374 |
|---|---|
| A49368 | |
| S29810 |
| Unigene ID | Hs.596992 |
|---|---|
| Mm.268797 | |
| Mm.361919 | |
| Rn.9686 |
| KEGG ID | hsa:6571 |
|---|---|
| mmu:214084 | |
| rno:25549 |
| Swiss-Prot ID | VMAT2_RAT |
|---|---|
| VMAT2_MOUSE | |
| VMAT2_HUMAN |
| Ensembl ID | ENSG00000165646 |
|---|---|
| ENSP00000298472 | |
| ENST00000298472 | |
| ENSMUSG00000025094 | |
| ENSMUSP00000026084 | |
| ENSMUST00000026084 | |
| ENSRNOG00000008890 | |
| ENSRNOP00000011983 | |
| ENSRNOT00000011983 |
| Homologene ID | 2298 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 106677 |
|---|
| RGD ID | 3694 |
|---|
| MedScan ID | 6571 |
|---|