| URN | urn:agi-llid:1621 |
|---|---|
| Connectivity | 166 |
| Name | Dbh |
| Description | dopamine beta-hydroxylase (dopamine beta-monooxygenase) |
| Notes | The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. [provided by RefSeq] |
| Pathway | epinephrine biosynthetic pathway |
|---|---|
| norepinephrine biosynthetic pathway | |
| norepinephrine biosynthetic pathway | |
| epinephrine biosynthetic pathway | |
| epinephrine biosynthetic pathway |
| GO Molecular Function | catalytic activity |
|---|---|
| oxidoreductase activity | |
| L-ascorbic acid binding | |
| metal ion binding | |
| copper ion binding | |
| monooxygenase activity | |
| dopamine beta-monooxygenase activity |
| GO Cellular Component | extracellular region |
|---|---|
| membrane | |
| soluble fraction | |
| cytoplasm | |
| cytoplasmic vesicle | |
| cytoplasmic membrane-bounded vesicle | |
| secretory granule lumen | |
| chromaffin granule lumen | |
| transport vesicle membrane | |
| chromaffin granule membrane | |
| chromaffin granule | |
| membrane fraction | |
| integral to membrane | |
| axon |
| GO Biological Process | cellular process |
|---|---|
| regulation of cell proliferation | |
| leukocyte migration | |
| cytokine production | |
| oxidation reduction | |
| positive regulation of vasoconstriction | |
| response to pain | |
| fear response | |
| behavioral response to ethanol | |
| visual learning | |
| blood vessel remodeling | |
| homoiothermy | |
| memory | |
| associative learning | |
| maternal behavior | |
| synaptic transmission | |
| regulation of apoptosis | |
| octopamine metabolic process | |
| histidine catabolic process | |
| catecholamine biosynthetic process | |
| norepinephrine biosynthetic process | |
| catecholamine metabolic process | |
| dopamine catabolic process | |
| leukocyte mediated immunity | |
| locomotory behavior | |
| response to amphetamine | |
| glucose homeostasis |
| Ariadne Ontology | Aromatic amino acid metabolism |
|---|
| Group | Aromatic amino acid metabolism |
|---|---|
| extracellular region | |
| catalytic activity | |
| cellular process | |
| regulation of cell proliferation | |
| leukocyte migration | |
| cytokine production | |
| oxidation reduction | |
| positive regulation of vasoconstriction | |
| response to pain | |
| fear response | |
| behavioral response to ethanol | |
| visual learning | |
| blood vessel remodeling | |
| homoiothermy | |
| memory | |
| associative learning | |
| maternal behavior | |
| synaptic transmission | |
| regulation of apoptosis | |
| octopamine metabolic process | |
| histidine catabolic process | |
| catecholamine biosynthetic process | |
| norepinephrine biosynthetic process | |
| catecholamine metabolic process | |
| dopamine catabolic process | |
| leukocyte mediated immunity | |
| locomotory behavior | |
| response to amphetamine | |
| glucose homeostasis | |
| oxidoreductase activity | |
| L-ascorbic acid binding | |
| metal ion binding | |
| copper ion binding | |
| monooxygenase activity | |
| dopamine beta-monooxygenase activity | |
| membrane | |
| soluble fraction | |
| cytoplasm | |
| cytoplasmic vesicle | |
| cytoplasmic membrane-bounded vesicle | |
| secretory granule lumen | |
| chromaffin granule lumen | |
| transport vesicle membrane | |
| chromaffin granule membrane | |
| chromaffin granule | |
| membrane fraction | |
| integral to membrane | |
| axon |
| MedScan ID | 1621 |
|---|
| Hugo ID | 2689 |
|---|
| Human chromosome position | 9q34 |
|---|
| LocusLink ID | 1621 |
|---|---|
| 13166 | |
| 25699 |
| Alias | DBM |
|---|---|
| RP11-317B10.1 | |
| dopamine beta-hydroxylase | |
| RP23-171K6.1 | |
| OTTMUSP00000012634 | |
| dopamine beta-monooxygenase | |
| DOPBHY | |
| Dopamine beta hydroxylase (dopamine beta-monooxygenase) | |
| Dbh | |
| Dopamine beta- hydroxylase | |
| dopamine beta hydroxylase | |
| dopamine beta-hydroxylase (dopamine beta-monooxygenase) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 609312 |
|---|---|
| 223360 | |
| 168600 |
| Mouse chromosome position | 2 15.5 cM |
|---|
| GO ID | 0031418 |
|---|---|
| 0003824 | |
| 0005507 | |
| 0004500 | |
| 0046872 | |
| 0004497 | |
| 0048149 | |
| 0001974 | |
| 0009987 | |
| 0001816 | |
| 0042420 | |
| 0042596 | |
| 0042593 | |
| 0006548 | |
| 0042309 | |
| 0002443 | |
| 0050900 | |
| 0007626 | |
| 0042711 | |
| 0007613 | |
| 0042421 | |
| 0046333 | |
| 0055114 | |
| 0045907 | |
| 0042981 | |
| 0042127 | |
| 0001975 | |
| 0048265 | |
| 0007268 | |
| 0008542 | |
| 0030424 | |
| 0042583 | |
| 0034466 | |
| 0042584 | |
| 0005737 | |
| 0016023 | |
| 0005576 | |
| 0016021 | |
| 0016020 | |
| 0005624 | |
| 0005625 | |
| 0030658 | |
| 0016491 | |
| 0008306 | |
| 0042423 | |
| 0006584 | |
| 0031410 | |
| 0034774 |
| Rat chromosome position | 3p12 |
|---|
| Swiss-Prot Accession | P09172 |
|---|---|
| Q3V1U4 | |
| Q64237 | |
| Q05754 | |
| Q5T381 | |
| Q96AG2 |
| PIR ID | S03020 |
|---|---|
| A61086 |
| Unigene ID | Hs.591890 |
|---|---|
| Mm.167781 | |
| Rn.87166 |
| KEGG ID | hsa:1621 |
|---|---|
| mmu:13166 | |
| rno:25699 |
| EC Number | 1.14.17.1 |
|---|
| Swiss-Prot ID | DOPO_HUMAN |
|---|---|
| DOPO_RAT | |
| Q3V1U4_MOUSE |
| Cell Localization | Cytoplasmic vesicle |
|---|---|
| secretory vesicle lumen | |
| secretory vesicle | |
| chromaffin granule lumen | |
| secretory vesicle membrane | |
| chromaffin granule membrane | |
| Cytoplasm |
| IPI ID | IPI00171678 |
|---|---|
| IPI00778951 | |
| IPI00132202 | |
| IPI00871997 | |
| IPI00514852 | |
| IPI00324490 |
| Homologene ID | 615 |
|---|
| RGD ID | 2489 |
|---|
| MGI ID | 94864 |
|---|