| URN | urn:agi-llid:7054 |
|---|---|
| Connectivity | 499 |
| Name | Th |
| Description | tyrosine hydroxylase |
| Notes | The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq] |
| Pathway | epinephrine biosynthetic pathway |
|---|---|
| norepinephrine biosynthetic pathway |
| Ariadne Ontology | Aromatic aminoacid metabolism |
|---|
| GO Molecular Function | protein binding |
|---|---|
| dopamine binding | |
| amino acid binding | |
| metal ion binding | |
| iron ion binding | |
| ferric iron binding | |
| ferrous iron binding | |
| oxidoreductase activity | |
| monooxygenase activity | |
| tyrosine 3-monooxygenase activity |
| GO Cellular Component | perikaryon |
|---|---|
| neuron projection | |
| terminal button | |
| axon | |
| cytoplasmic vesicle membrane | |
| melanosome membrane | |
| cytoplasm | |
| mitochondrion | |
| cytoplasmic vesicle | |
| cytosol | |
| synaptic vesicle | |
| smooth endoplasmic reticulum | |
| nucleus | |
| internal side of plasma membrane |
| GO Biological Process | pigmentation |
|---|---|
| protein homotetramerization | |
| regulation of heart contraction | |
| neurotransmitter biosynthetic process | |
| synaptic transmission | |
| synaptic transmission, dopaminergic | |
| eye photoreceptor cell development | |
| catecholamine biosynthetic process | |
| epinephrine biosynthetic process | |
| norepinephrine biosynthetic process | |
| dopamine biosynthetic process from tyrosine | |
| aromatic amino acid family metabolic process | |
| organ morphogenesis | |
| embryonic camera-type eye morphogenesis | |
| heart morphogenesis | |
| heart development | |
| oxidation reduction | |
| mating behavior | |
| memory | |
| learning | |
| visual perception | |
| response to stress | |
| locomotory behavior | |
| eating behavior | |
| response to steroid hormone stimulus | |
| response to ethanol | |
| response to hypoxia |
| Group | Aromatic aminoacid metabolism |
|---|---|
| perikaryon | |
| neuron projection | |
| terminal button | |
| axon | |
| cytoplasmic vesicle membrane | |
| melanosome membrane | |
| cytoplasm | |
| mitochondrion | |
| cytoplasmic vesicle | |
| cytosol | |
| synaptic vesicle | |
| smooth endoplasmic reticulum | |
| nucleus | |
| internal side of plasma membrane | |
| protein binding | |
| dopamine binding | |
| amino acid binding | |
| metal ion binding | |
| iron ion binding | |
| ferric iron binding | |
| ferrous iron binding | |
| oxidoreductase activity | |
| monooxygenase activity | |
| tyrosine 3-monooxygenase activity | |
| pigmentation | |
| protein homotetramerization | |
| regulation of heart contraction | |
| neurotransmitter biosynthetic process | |
| synaptic transmission | |
| synaptic transmission, dopaminergic | |
| eye photoreceptor cell development | |
| catecholamine biosynthetic process | |
| epinephrine biosynthetic process | |
| norepinephrine biosynthetic process | |
| dopamine biosynthetic process from tyrosine | |
| aromatic amino acid family metabolic process | |
| organ morphogenesis | |
| embryonic camera-type eye morphogenesis | |
| heart morphogenesis | |
| heart development | |
| oxidation reduction | |
| mating behavior | |
| memory | |
| learning | |
| visual perception | |
| response to stress | |
| locomotory behavior | |
| eating behavior | |
| response to steroid hormone stimulus | |
| response to ethanol | |
| response to hypoxia |
| Hugo ID | 11782 |
|---|
| Human chromosome position | 11p15.5 |
|---|
| LocusLink ID | 7054 |
|---|---|
| 21823 | |
| 25085 |
| Alias | TYH |
|---|---|
| tyrosine hydroxylase | |
| OTTHUMP00000011225 | |
| OTTHUMP00000011226 | |
| tyrosine 3-monooxygenase | |
| OTTMUSP00000020341 | |
| The | |
| Tyrosine 3-hydroxylase | |
| L-tyrosine hydroxylase | |
| L-tyrosine hydroxylases | |
| LOC90736 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 191290 |
|---|---|
| 605407 |
| Swiss-Prot Accession | P07101 |
|---|---|
| P78428 | |
| O43816 | |
| Q0PWM2 | |
| Q0PWM3 | |
| Q15587 | |
| Q16846 | |
| Q2M3B4 | |
| Q6XS77 | |
| Q7KZ36 | |
| Q7KZ38 | |
| Q7KZ39 | |
| Q7KZ44 | |
| Q8IZE1 | |
| Q8IZE2 | |
| Q8IZQ6 | |
| Q8IZQ7 | |
| Q9NP14 | |
| Q9UQ57 | |
| P24529 | |
| Q3UTB3 | |
| Q91ZN2 | |
| P04177 | |
| P97904 | |
| Q78E18 |
| Unigene ID | Hs.435609 |
|---|---|
| Mm.1292 | |
| Rn.11082 |
| KEGG ID | mmu:21823 |
|---|---|
| rno:25085 |
| EC Number | 1.14.16.2 |
|---|
| Swiss-Prot ID | TY3H_HUMAN |
|---|---|
| TY3H_MOUSE | |
| TY3H_RAT | |
| B7ZL70_HUMAN | |
| P78428_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0005506 |
|---|---|
| 0046872 | |
| 0004497 | |
| 0005515 | |
| 0004511 | |
| 0009072 | |
| 0006585 | |
| 0048596 | |
| 0042418 | |
| 0042462 | |
| 0003007 | |
| 0007612 | |
| 0007626 | |
| 0007613 | |
| 0042136 | |
| 0042421 | |
| 0055114 | |
| 0043473 | |
| 0008016 | |
| 0045471 | |
| 0001666 | |
| 0007268 | |
| 0001963 | |
| 0007601 | |
| 0005737 | |
| 0031410 | |
| 0009898 | |
| 0033162 | |
| 0043005 | |
| 0005634 | |
| 0043204 | |
| 0005790 | |
| 0016491 | |
| 0042423 | |
| 0042755 | |
| 0007507 | |
| 0007617 | |
| 0009887 | |
| 0016597 | |
| 0035240 | |
| 0008199 | |
| 0008198 | |
| 0051289 | |
| 0048545 | |
| 0006950 | |
| 0030424 | |
| 0030659 | |
| 0005829 | |
| 0005739 | |
| 0008021 | |
| 0043195 |
| IPI ID | IPI00010178 |
|---|---|
| IPI00218275 | |
| IPI00218276 | |
| IPI00398179 | |
| IPI00217988 | |
| IPI00873437 | |
| IPI00873432 | |
| IPI00878515 | |
| IPI00878304 | |
| IPI00138131 | |
| IPI00831270 | |
| IPI00831043 | |
| IPI00880254 | |
| IPI00880391 | |
| IPI00881265 | |
| IPI00193259 |
| Mouse chromosome position | 7 69.2 cM |
|---|
| Homologene ID | 307 |
|---|
| MGI ID | 98735 |
|---|
| Rat chromosome position | 1q41 |
|---|
| RGD ID | 3853 |
|---|