| URN | urn:agi-llid:1644 |
|---|---|
| Total Entities | 0 |
| Connectivity | 547 |
| Name | Ddc |
| Description | dopa decarboxylase (aromatic L-amino acid decarboxylase) |
| Notes | The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq] |
| GO Molecular Function | catalytic activity |
|---|---|
| lyase activity | |
| carboxy-lyase activity | |
| aromatic-L-amino-acid decarboxylase activity | |
| protein domain specific binding | |
| amino acid binding | |
| pyridoxal phosphate binding |
| GO Cellular Component | intracellular |
|---|---|
| cytoplasm | |
| cytosol | |
| synaptic vesicle | |
| axon | |
| neuronal cell body |
| GO Biological Process | small molecule metabolic process |
|---|---|
| carboxylic acid metabolic process | |
| cellular amino acid metabolic process | |
| phytoalexin metabolic process | |
| multicellular organismal aging | |
| synaptic vesicle amine transport | |
| response to toxic substance | |
| cellular response to drug | |
| cellular response to growth factor stimulus | |
| cellular response to alkaloid | |
| response to pyrethroid | |
| cellular nitrogen compound metabolic process | |
| isoquinoline alkaloid metabolic process | |
| serotonin biosynthetic process | |
| indolalkylamine biosynthetic process | |
| catecholamine biosynthetic process | |
| dopamine biosynthetic process | |
| dopamine metabolic process | |
| circadian rhythm |
| Pathway | Young Onset SNCA Induced Parkinson's Disease |
|---|---|
| Dopamine Metabolism in Parkinson's Disease | |
| Endothelial Cell Dysfunction in Pulmonary Arterial Hypertension | |
| GALR1/2/3 -> neurotransmitter metabolism | |
| peripheral dopamine signaling pathway | |
| epinephrine biosynthetic pathway | |
| norepinephrine biosynthetic pathway | |
| norepinephrine biosynthetic pathway | |
| epinephrine biosynthetic pathway | |
| norepinephrine biosynthetic pathway | |
| dopamine biosynthetic pathway | |
| epinephrine biosynthetic pathway |
| Group | Aromatic amino acid metabolism |
|---|---|
| His metabolism | |
| small molecule metabolic process | |
| carboxylic acid metabolic process | |
| cellular amino acid metabolic process | |
| phytoalexin metabolic process | |
| multicellular organismal aging | |
| synaptic vesicle amine transport | |
| response to toxic substance | |
| cellular response to drug | |
| cellular response to growth factor stimulus | |
| cellular response to alkaloid | |
| response to pyrethroid | |
| catalytic activity | |
| lyase activity | |
| carboxy-lyase activity | |
| aromatic-L-amino-acid decarboxylase activity | |
| cellular nitrogen compound metabolic process | |
| isoquinoline alkaloid metabolic process | |
| serotonin biosynthetic process | |
| indolalkylamine biosynthetic process | |
| catecholamine biosynthetic process | |
| dopamine biosynthetic process | |
| dopamine metabolic process | |
| circadian rhythm | |
| protein domain specific binding | |
| amino acid binding | |
| pyridoxal phosphate binding | |
| intracellular | |
| cytoplasm | |
| cytosol | |
| synaptic vesicle | |
| axon | |
| neuronal cell body | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 1644 |
|---|---|
| 13195 | |
| 24311 |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0016597 |
|---|---|
| 0004058 | |
| 0019904 | |
| 0030170 | |
| 0042423 | |
| 0006520 | |
| 0034641 | |
| 0071312 | |
| 0035690 | |
| 0071363 | |
| 0007623 | |
| 0042416 | |
| 0046219 | |
| 0033076 | |
| 0010259 | |
| 0052314 | |
| 0046684 | |
| 0042427 | |
| 0044281 | |
| 0015842 | |
| 0030424 | |
| 0005829 | |
| 0043025 | |
| 0008021 | |
| 0016831 | |
| 0003824 | |
| 0016829 | |
| 0019752 | |
| 0009636 | |
| 0005737 | |
| 0042417 | |
| 0005622 | |
| 0006519 | |
| 0042428 | |
| 0005515 |
| Alias | AADC |
|---|---|
| aromatic-L-amino-acid decarboxylase | |
| RP23-373H2.3 | |
| L-Dopa decarboxylase | |
| L-phenylalanine decarboxylase | |
| L-phenylalanine decarboxylases | |
| MGC93628 | |
| OTTHUMP00000209022 | |
| OTTHUMP00000209025 | |
| phenylalanine decarboxylases | |
| OTTMUSP00000005369 | |
| phenylalanine decarboxylase | |
| L-amino acid decarboxylase | |
| OTTHUMP00000209026 | |
| aromatic L-amino acid decarboxylase | |
| amino acid decarboxylase | |
| human L-amino acid decarboxylase | |
| aromatic amino acid decarboxylase | |
| DDC decarboxylase | |
| DDC enzyme | |
| DOPA decarboxylase | |
| dopa decarboxylase (aromatic L-amino acid decarboxylase) | |
| enzyme DDC | |
| hAADC | |
| DDC protein |
| Mouse chromosome position | 11 7.09 cM |
|---|---|
| 11 7.0 cM |
| OMIM ID | 107930 |
|---|---|
| 608643 |
| Rat chromosome position | 14q21 |
|---|
| Hugo ID | 2719 |
|---|
| Human chromosome position | 7p12.2 |
|---|
| Swiss-Prot Accession | P20711 |
|---|---|
| Q53Y41 | |
| O88533 | |
| Q5SUV8 | |
| P14173 | |
| D3ZMA5 | |
| C9IYA0 | |
| E7ER62 | |
| E7EU95 | |
| Q16723 | |
| Q5W5T9 | |
| Q75MJ6 | |
| Q6LEG4 | |
| F8TLS6 | |
| Q6IBS8 | |
| O35958 | |
| Q3TUH2 | |
| Q5SUV9 | |
| Q62819 |
| PIR ID | A33663 |
|---|---|
| A33994 |
| Unigene ID | Hs.359698 |
|---|---|
| Mm.12906 | |
| Rn.11064 |
| KEGG ID | hsa:1644 |
|---|---|
| mmu:13195 | |
| rno:24311 |
| Swiss-Prot ID | DDC_MOUSE |
|---|---|
| DDC_HUMAN | |
| DDC_RAT | |
| Q53Y41_HUMAN | |
| Q5SUV8_MOUSE |
| EC Number | 4.1.1.28 |
|---|
| Ensembl ID | ENSG00000132437 |
|---|---|
| ENSP00000350616 | |
| ENST00000357936 | |
| ENSP00000403644 | |
| ENST00000444124 | |
| ENSP00000395069 | |
| ENST00000426377 | |
| ENSP00000399184 | |
| ENST00000431062 | |
| ENSP00000370371 | |
| ENST00000380984 | |
| ENSMUSG00000020182 | |
| ENSMUSP00000136467 | |
| ENSMUST00000178704 | |
| ENSMUSP00000105286 | |
| ENSMUST00000109659 | |
| ENSRNOG00000004327 | |
| ENSRNOP00000064520 | |
| ENSRNOT00000073892 |
| Homologene ID | 618 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 94876 |
|---|
| RGD ID | 2494 |
|---|
| MedScan ID | 1644 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00470246 |
|---|---|
| IPI00131814 | |
| IPI00025394 | |
| IPI00477841 | |
| IPI00479686 | |
| IPI00654045 | |
| IPI00649940 | |
| IPI00567511 | |
| IPI00779983 |