| URN | urn:agi-llid:1621 |
|---|---|
| Total Entities | 0 |
| Connectivity | 566 |
| Name | Dbh |
| Description | dopamine beta-hydroxylase (dopamine beta-monooxygenase) |
| Notes | The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. [provided by RefSeq] |
| GO Molecular Function | oxidoreductase activity |
|---|---|
| monooxygenase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen | |
| dopamine beta-monooxygenase activity | |
| catalytic activity | |
| L-ascorbic acid binding | |
| metal ion binding | |
| copper ion binding |
| GO Cellular Component | membrane |
|---|---|
| synapse | |
| extracellular region | |
| integral component of membrane | |
| transport vesicle membrane | |
| chromaffin granule membrane | |
| secretory granule lumen | |
| chromaffin granule lumen | |
| apical part of cell | |
| cytoplasm | |
| cytoplasmic vesicle | |
| cytoplasmic membrane-bounded vesicle | |
| chromaffin granule | |
| terminal bouton | |
| varicosity | |
| axon | |
| dendrite | |
| neuronal cell body |
| GO Biological Process | maternal behavior |
|---|---|
| leukocyte migration | |
| leukocyte mediated immunity | |
| small molecule metabolic process | |
| oxidation-reduction process | |
| octopamine metabolic process | |
| cytokine production | |
| homoiothermy | |
| positive regulation of vasoconstriction | |
| blood vessel remodeling | |
| sensory perception of taste | |
| memory | |
| associative learning | |
| visual learning | |
| multicellular organismal aging | |
| bone development | |
| behavioral response to ethanol | |
| response to pain | |
| fear response | |
| regulation of extrinsic apoptotic signaling pathway | |
| synaptic transmission | |
| regulation of apoptotic process | |
| regulation of cell proliferation | |
| response to drug | |
| response to ozone | |
| response to estradiol | |
| response to ethanol | |
| response to peptide hormone | |
| response to iron ion | |
| response to copper ion | |
| cellular response to manganese ion | |
| cellular response to nicotine | |
| response to organic cyclic compound | |
| response to amphetamine | |
| locomotory behavior | |
| social behavior | |
| cellular nitrogen compound metabolic process | |
| catecholamine biosynthetic process | |
| norepinephrine biosynthetic process | |
| dopamine catabolic process | |
| catecholamine metabolic process | |
| glucose homeostasis |
| Pathway | PHOX2B-Associated Neuroblastoma |
|---|---|
| Neuroblastoma Overview | |
| epinephrine biosynthetic pathway | |
| norepinephrine biosynthetic pathway | |
| norepinephrine biosynthetic pathway | |
| epinephrine biosynthetic pathway | |
| norepinephrine biosynthetic pathway | |
| epinephrine biosynthetic pathway |
| Group | Aromatic amino acid metabolism |
|---|---|
| maternal behavior | |
| leukocyte migration | |
| leukocyte mediated immunity | |
| small molecule metabolic process | |
| oxidation-reduction process | |
| oxidoreductase activity | |
| monooxygenase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen | |
| dopamine beta-monooxygenase activity | |
| octopamine metabolic process | |
| cytokine production | |
| homoiothermy | |
| positive regulation of vasoconstriction | |
| blood vessel remodeling | |
| sensory perception of taste | |
| memory | |
| associative learning | |
| visual learning | |
| multicellular organismal aging | |
| bone development | |
| behavioral response to ethanol | |
| response to pain | |
| fear response | |
| regulation of extrinsic apoptotic signaling pathway | |
| synaptic transmission | |
| regulation of apoptotic process | |
| regulation of cell proliferation | |
| response to drug | |
| response to ozone | |
| response to estradiol | |
| response to ethanol | |
| response to peptide hormone | |
| response to iron ion | |
| response to copper ion | |
| cellular response to manganese ion | |
| cellular response to nicotine | |
| response to organic cyclic compound | |
| response to amphetamine | |
| locomotory behavior | |
| social behavior | |
| catalytic activity | |
| cellular nitrogen compound metabolic process | |
| catecholamine biosynthetic process | |
| norepinephrine biosynthetic process | |
| dopamine catabolic process | |
| catecholamine metabolic process | |
| glucose homeostasis | |
| L-ascorbic acid binding | |
| metal ion binding | |
| copper ion binding | |
| membrane | |
| synapse | |
| extracellular region | |
| integral component of membrane | |
| transport vesicle membrane | |
| chromaffin granule membrane | |
| secretory granule lumen | |
| chromaffin granule lumen | |
| apical part of cell | |
| cytoplasm | |
| cytoplasmic vesicle | |
| cytoplasmic membrane-bounded vesicle | |
| chromaffin granule | |
| terminal bouton | |
| varicosity | |
| axon | |
| dendrite | |
| neuronal cell body | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 1621 |
|---|---|
| 13166 | |
| 25699 |
| Cell Localization | Cytoplasm |
|---|---|
| Cytoplasmic vesicle | |
| Secretory vesicle lumen | |
| Secretory vesicle | |
| Chromaffin granule lumen | |
| Secretory vesicle membrane | |
| Chromaffin granule membrane |
| GO ID | 0031418 |
|---|---|
| 0003824 | |
| 0005507 | |
| 0004500 | |
| 0048149 | |
| 0001974 | |
| 0042423 | |
| 0034641 | |
| 0001816 | |
| 0042420 | |
| 0042596 | |
| 0042593 | |
| 0042309 | |
| 0002443 | |
| 0050900 | |
| 0007626 | |
| 0042711 | |
| 0007613 | |
| 0042421 | |
| 0045907 | |
| 0042981 | |
| 0042127 | |
| 0001975 | |
| 0048265 | |
| 0044281 | |
| 0007268 | |
| 0008542 | |
| 0042583 | |
| 0034466 | |
| 0042584 | |
| 0005737 | |
| 0005576 | |
| 0016021 | |
| 0016020 | |
| 0034774 | |
| 0030658 | |
| 0046872 | |
| 0004497 | |
| 0016491 | |
| 0016715 | |
| 0008306 | |
| 0046333 | |
| 0055114 | |
| 2001236 | |
| 0045177 | |
| 0030424 | |
| 0016023 | |
| 0031410 | |
| 0030425 | |
| 0043025 | |
| 0045202 | |
| 0043195 | |
| 0043196 | |
| 0060348 | |
| 0006584 | |
| 0071287 | |
| 0071316 | |
| 0010259 | |
| 0046688 | |
| 0042493 | |
| 0032355 | |
| 0045471 | |
| 0010039 | |
| 0014070 | |
| 0010193 | |
| 0043434 | |
| 0050909 | |
| 0035176 | |
| 0009987 | |
| 0006548 | |
| 0005624 | |
| 0005625 |
| Alias | DBM |
|---|---|
| RP11-317B10.1 | |
| dopamine beta-hydroxylase | |
| RP23-171K6.1 | |
| dopamine beta-monooxygenase | |
| DOPBHY | |
| Dopamine beta hydroxylase (dopamine beta-monooxygenase) | |
| OTTMUSP00000012634 | |
| Dopamine beta- hydroxylase | |
| Dbh | |
| dopamine beta hydroxylase | |
| dopamine beta-hydroxylase (dopamine beta-monooxygenase) |
| Mouse chromosome position | 2 19.29 cM |
|---|---|
| 2 15.5 cM |
| OMIM ID | 609312 |
|---|---|
| 223360 | |
| 168600 |
| Rat chromosome position | 3p12 |
|---|
| Hugo ID | 2689 |
|---|
| Human chromosome position | 9q34 |
|---|
| Swiss-Prot Accession | P09172 |
|---|---|
| Q64237 | |
| Q05754 | |
| Q5T381 | |
| Q96AG2 | |
| Q3V1U4 |
| PIR ID | A61086 |
|---|---|
| S03020 | |
| JC1346 |
| Unigene ID | Hs.591890 |
|---|---|
| Mm.167781 | |
| Rn.87166 |
| KEGG ID | hsa:1621 |
|---|---|
| mmu:13166 | |
| rno:25699 |
| Swiss-Prot ID | DOPO_RAT |
|---|---|
| DOPO_HUMAN | |
| DOPO_MOUSE | |
| Q3V1U4_MOUSE |
| EC Number | 1.14.17.1 |
|---|
| Ensembl ID | ENSG00000123454 |
|---|---|
| ENSP00000376776 | |
| ENST00000393056 | |
| ENSMUSG00000000889 | |
| ENSMUSP00000000910 | |
| ENSMUST00000000910 | |
| ENSRNOG00000006641 | |
| ENSRNOP00000057915 | |
| ENSRNOT00000061201 |
| Homologene ID | 615 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 94864 |
|---|
| RGD ID | 2489 |
|---|
| MedScan ID | 1621 |
|---|
| IPI ID | IPI00171678 |
|---|---|
| IPI00871997 | |
| IPI00514852 | |
| IPI00132202 | |
| IPI00324490 | |
| IPI00778951 |