| URN | urn:agi-llid:5409 |
|---|---|
| Connectivity | 67 |
| Name | Pnmt |
| Description | phenylethanolamine N-methyltransferase |
| Notes | The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production. [provided by RefSeq] |
| Pathway | epinephrine biosynthetic pathway |
|---|
| Ariadne Ontology | Aromatic aminoacid metabolism |
|---|
| GO Molecular Function | transferase activity |
|---|---|
| methyltransferase activity | |
| phenylethanolamine N-methyltransferase activity |
| GO Biological Process | catecholamine biosynthetic process |
|---|
| Group | Aromatic aminoacid metabolism |
|---|---|
| transferase activity | |
| methyltransferase activity | |
| phenylethanolamine N-methyltransferase activity | |
| catecholamine biosynthetic process |
| Hugo ID | 9160 |
|---|
| Human chromosome position | 17q21-q22 |
|---|
| LocusLink ID | 5409 |
|---|---|
| 18948 |
| Alias | PENT |
|---|---|
| PNMTase | |
| MGC34570 | |
| phenylethanolamine N-methyltransferase | |
| OTTHUMP00000164271 | |
| phenylethanolamine N-methylase | |
| noradrenaline N-methyltransferase | |
| RP23-355L10.6 | |
| OTTMUSP00000002543 | |
| norepinephrine methyltransferase | |
| norepinephrine N-methyltransferase | |
| phenethanolamine methyltransferase | |
| phenethanolamine N-methyltransferase | |
| Pnmt | |
| noradrenalin N-methyltransferases | |
| norepinephrine methyltransferases | |
| norepinephrine N-methyltransferases | |
| phenethanolamine methyltransferases | |
| phenethanolamine N-methyltransferases | |
| noradrenalin N-methyltransferase | |
| PNMTases |
| Organism | Homo sapiens |
|---|---|
| Mus musculus |
| OMIM ID | 171190 |
|---|
| Swiss-Prot Accession | P11086 |
|---|---|
| Q6FHD9 | |
| P40935 | |
| Q0VB50 |
| Unigene ID | Hs.1892 |
|---|---|
| Mm.57030 |
| KEGG ID | hsa:5409 |
|---|
| EC Number | 2.1.1.28 |
|---|
| Swiss-Prot ID | PNMT_HUMAN |
|---|---|
| PNMT_MOUSE | |
| Q0VB50_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0008168 |
|---|---|
| 0004603 | |
| 0016740 | |
| 0042423 |
| IPI ID | IPI00003466 |
|---|---|
| IPI00797601 | |
| IPI00796949 | |
| IPI00789112 | |
| IPI00114624 |
| Mouse chromosome position | 11 D |
|---|
| Homologene ID | 55673 |
|---|
| MGI ID | 97724 |
|---|
| RGD ID | 3361 |
|---|