| URN | urn:agi-llid:7054 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1891 |
| Name | Th |
| Description | tyrosine hydroxylase |
| Notes | The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq] |
| GO Molecular Function | oxidoreductase activity |
|---|---|
| monooxygenase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen | |
| tyrosine 3-monooxygenase activity | |
| oxygen binding | |
| protein domain specific binding | |
| amino acid binding | |
| tetrahydrobiopterin binding | |
| dopamine binding | |
| metal ion binding | |
| iron ion binding | |
| ferrous iron binding | |
| ferric iron binding |
| GO Cellular Component | cytoplasmic side of plasma membrane |
|---|---|
| melanosome membrane | |
| cytoplasmic vesicle membrane | |
| cytoplasm | |
| cytosol | |
| cytoplasmic vesicle | |
| mitochondrion | |
| smooth endoplasmic reticulum | |
| synaptic vesicle | |
| nucleus | |
| terminal bouton | |
| neuron projection | |
| axon | |
| dendrite | |
| perikaryon | |
| neuronal cell body |
| GO Biological Process | mating behavior |
|---|---|
| pigmentation | |
| small molecule metabolic process | |
| oxidation-reduction process | |
| dopamine biosynthetic process from tyrosine | |
| fatty acid metabolic process | |
| sphingolipid metabolic process | |
| terpene metabolic process | |
| aromatic amino acid family metabolic process | |
| phthalate metabolic process | |
| phytoalexin metabolic process | |
| glycoside metabolic process | |
| cognition | |
| visual perception | |
| sensory perception of sound | |
| learning | |
| memory | |
| regulation of heart contraction | |
| multicellular organismal aging | |
| organ morphogenesis | |
| heart development | |
| eye photoreceptor cell development | |
| embryonic camera-type eye morphogenesis | |
| heart morphogenesis | |
| cerebral cortex development | |
| neurotransmitter biosynthetic process | |
| synaptic transmission, dopaminergic | |
| synaptic vesicle amine transport | |
| cellular response to glucose stimulus | |
| response to activity | |
| response to drug | |
| response to ether | |
| response to lipopolysaccharide | |
| response to water deprivation | |
| response to corticosterone | |
| response to estradiol | |
| response to ethanol | |
| response to peptide hormone | |
| response to metal ion | |
| response to zinc ion | |
| cellular response to manganese ion | |
| cellular response to drug | |
| cellular response to growth factor stimulus | |
| cellular response to nicotine | |
| cellular response to alkaloid | |
| response to growth factor | |
| response to organic cyclic compound | |
| response to steroid hormone | |
| response to nicotine | |
| response to amphetamine | |
| response to herbicide | |
| response to insecticide | |
| response to pyrethroid | |
| response to hypoxia | |
| response to immobilization stress | |
| response to salt stress | |
| response to nutrient levels | |
| locomotory behavior | |
| eating behavior | |
| social behavior | |
| circadian sleep-wake cycle | |
| response to electrical stimulus | |
| response to light stimulus | |
| anatomical structure morphogenesis | |
| cellular nitrogen compound metabolic process | |
| isoquinoline alkaloid metabolic process | |
| catecholamine biosynthetic process | |
| epinephrine biosynthetic process | |
| norepinephrine biosynthetic process | |
| dopamine biosynthetic process | |
| protein homotetramerization |
| Pathway | Young Onset SNCA Induced Parkinson's Disease |
|---|---|
| Proteins Involved in Pathogenesis of Parkinson's Disease | |
| Dopamine Metabolism in Parkinson's Disease | |
| Young Onset PARK7 and LRRK2 Induced Parkinson's Disease | |
| PHOX2B-Associated Neuroblastoma | |
| Proteins Involved in Pathogenesis of Neuroblastoma | |
| Neuroblastoma Overview | |
| TGFB3-TGFBR2 Expression Targets | |
| TGFB1-TGFBR2 Expression Targets | |
| BMP4-BMPR2 Expression Targets | |
| BDNF Expression Targets | |
| NTF3 Expression Targets | |
| NGF/AP-1/TP53/MYC Expression Targets | |
| NGF/SMAD3/NF-kB Expression Targets | |
| GH1-GHR/NF-kB/ELK-SRF/MYC Expression Targets | |
| GH1-GHR/STAT Expression Targets | |
| GH1-PRLR Expression Targets | |
| CNTF Expression Targets | |
| Leptin/ELK-SRF Expression Targets | |
| Leptin/STAT Expression Targets | |
| NPY Expression Targets | |
| Dopamine/Gi Expression Targets | |
| Acetylcholine Expression Targets | |
| FGF1/STAT Expression Targets | |
| GDNF/HSF1 Expression Targets | |
| FGF1/AP-1/CREB/ELK-SRF/MYC Expression Targets | |
| FGF8/AP-1/CREB/MYC Expression Targets | |
| F2 -> AP-1/CREB/ELK-SRF/SP1 Expression Targets | |
| AVP/Gq -> CREB/ELK-SRF/AP-1/EGR Expression Targets | |
| Morphine Expression Targets | |
| NTS Expression Targets | |
| PGE1 Expression Targets | |
| VIP Expression Targets | |
| Dopamine/Gs Expression Targets | |
| GCG Expression Targets | |
| AVP/Gs -> CREB/ELK-SRF/AP-1/EGR Expression Targets | |
| Serotonin/Gs Expression Targets | |
| POMC Expression Targets | |
| ADCYAP1 Expression Targets | |
| AGT/ELK-SRF Expression Targets | |
| FGF2/AP-1/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| IGF1/STAT Expression Targets | |
| FGF2/STAT Expression Targets | |
| INHBA-ACVR2/BMPR Expression Targets | |
| AGT/CREB Expression Targets | |
| AGT/STAT Expression Targets | |
| EGF/AP-1/ATF Expression Targets | |
| EGF/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| EGF/MEF/MYOD/NFATC Expression Targets | |
| EGF/STAT Expression Targets | |
| IGF1/ELK-SRF/HIF1A/MYC/SREBF Expression Targets | |
| IGF1/MEF/MYOD/MYOG Expression Targets | |
| IL1B/NO Expression Targets | |
| TGFB1-ACVRL1 Expression Targets | |
| TGFB1-TGFBR1/AP-1 Expression Targets | |
| IL1B Expression Targets | |
| EGF/CTNN Expression Targets | |
| epinephrine biosynthetic pathway | |
| norepinephrine biosynthetic pathway | |
| norepinephrine biosynthetic pathway | |
| epinephrine biosynthetic pathway | |
| norepinephrine biosynthetic pathway | |
| dopamine biosynthetic pathway | |
| epinephrine biosynthetic pathway |
| Group | Aromatic amino acid metabolism |
|---|---|
| mating behavior | |
| pigmentation | |
| small molecule metabolic process | |
| oxidation-reduction process | |
| dopamine biosynthetic process from tyrosine | |
| oxidoreductase activity | |
| monooxygenase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen | |
| tyrosine 3-monooxygenase activity | |
| fatty acid metabolic process | |
| sphingolipid metabolic process | |
| terpene metabolic process | |
| aromatic amino acid family metabolic process | |
| phthalate metabolic process | |
| phytoalexin metabolic process | |
| glycoside metabolic process | |
| cognition | |
| visual perception | |
| sensory perception of sound | |
| learning | |
| memory | |
| regulation of heart contraction | |
| multicellular organismal aging | |
| organ morphogenesis | |
| heart development | |
| eye photoreceptor cell development | |
| embryonic camera-type eye morphogenesis | |
| heart morphogenesis | |
| cerebral cortex development | |
| neurotransmitter biosynthetic process | |
| synaptic transmission, dopaminergic | |
| synaptic vesicle amine transport | |
| cellular response to glucose stimulus | |
| response to activity | |
| response to drug | |
| response to ether | |
| response to lipopolysaccharide | |
| response to water deprivation | |
| response to corticosterone | |
| response to estradiol | |
| response to ethanol | |
| response to peptide hormone | |
| response to metal ion | |
| response to zinc ion | |
| cellular response to manganese ion | |
| cellular response to drug | |
| cellular response to growth factor stimulus | |
| cellular response to nicotine | |
| cellular response to alkaloid | |
| response to growth factor | |
| response to organic cyclic compound | |
| response to steroid hormone | |
| response to nicotine | |
| response to amphetamine | |
| response to herbicide | |
| response to insecticide | |
| response to pyrethroid | |
| response to hypoxia | |
| response to immobilization stress | |
| response to salt stress | |
| response to nutrient levels | |
| locomotory behavior | |
| eating behavior | |
| social behavior | |
| circadian sleep-wake cycle | |
| response to electrical stimulus | |
| response to light stimulus | |
| anatomical structure morphogenesis | |
| cellular nitrogen compound metabolic process | |
| isoquinoline alkaloid metabolic process | |
| catecholamine biosynthetic process | |
| epinephrine biosynthetic process | |
| norepinephrine biosynthetic process | |
| dopamine biosynthetic process | |
| protein homotetramerization | |
| oxygen binding | |
| protein domain specific binding | |
| amino acid binding | |
| tetrahydrobiopterin binding | |
| dopamine binding | |
| metal ion binding | |
| iron ion binding | |
| ferrous iron binding | |
| ferric iron binding | |
| cytoplasmic side of plasma membrane | |
| melanosome membrane | |
| cytoplasmic vesicle membrane | |
| cytoplasm | |
| cytosol | |
| cytoplasmic vesicle | |
| mitochondrion | |
| smooth endoplasmic reticulum | |
| synaptic vesicle | |
| nucleus | |
| terminal bouton | |
| neuron projection | |
| axon | |
| dendrite | |
| perikaryon | |
| neuronal cell body | |
| Proteins Involved in Pathogenesis of Hypopituitarism | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 7054 |
|---|---|
| 21823 | |
| 25085 |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0016597 |
|---|---|
| 0035240 | |
| 0008199 | |
| 0008198 | |
| 0019825 | |
| 0019904 | |
| 0034617 | |
| 0004511 | |
| 0009653 | |
| 0042423 | |
| 0034641 | |
| 0035690 | |
| 0071333 | |
| 0071363 | |
| 0071287 | |
| 0071316 | |
| 0021987 | |
| 0042745 | |
| 0042416 | |
| 0006585 | |
| 0042755 | |
| 0048596 | |
| 0042418 | |
| 0042462 | |
| 0006631 | |
| 0016137 | |
| 0007507 | |
| 0003007 | |
| 0033076 | |
| 0007612 | |
| 0007626 | |
| 0007617 | |
| 0007613 | |
| 0010259 | |
| 0042136 | |
| 0042421 | |
| 0009887 | |
| 0018963 | |
| 0052314 | |
| 0043473 | |
| 0008016 | |
| 0014823 | |
| 0001975 | |
| 0051412 | |
| 0051602 | |
| 0032355 | |
| 0045471 | |
| 0045472 | |
| 0009635 | |
| 0001666 | |
| 0009416 | |
| 0032496 | |
| 0031667 | |
| 0043434 | |
| 0046684 | |
| 0009651 | |
| 0009414 | |
| 0010043 | |
| 0007605 | |
| 0044281 | |
| 0035176 | |
| 0006665 | |
| 0001963 | |
| 0015842 | |
| 0042214 | |
| 0007601 | |
| 0005737 | |
| 0009898 | |
| 0031410 | |
| 0005829 | |
| 0030425 | |
| 0033162 | |
| 0005739 | |
| 0043005 | |
| 0005634 | |
| 0043204 | |
| 0005790 | |
| 0008021 | |
| 0043195 | |
| 0005506 | |
| 0046872 | |
| 0004497 | |
| 0016491 | |
| 0016714 | |
| 0009072 | |
| 0055114 | |
| 0030424 | |
| 0030659 | |
| 0043025 | |
| 0071312 | |
| 0050890 | |
| 0051289 | |
| 0042493 | |
| 0070848 | |
| 0035902 | |
| 0017085 | |
| 0010038 | |
| 0035094 | |
| 0014070 | |
| 0048545 | |
| 0005515 | |
| 0007268 | |
| 0006950 |
| Alias | TYH |
|---|---|
| DYT14 | |
| DYT5b | |
| tyrosine 3-monooxygenase | |
| dystonia 14 | |
| tyrosine 3-hydroxylase | |
| The | |
| L-tyrosine hydroxylases | |
| OTTMUSP00000020341 | |
| tyrosine hydroxylase | |
| L-tyrosine hydroxylase | |
| LOC90736 | |
| OTTHUMP00000011226 | |
| OTTHUMP00000011225 |
| Mouse chromosome position | 7 88.06 cM |
|---|---|
| 7 69.2 cM |
| OMIM ID | 191290 |
|---|---|
| 605407 |
| Rat chromosome position | 1q41 |
|---|
| Hugo ID | 11782 |
|---|
| Human chromosome position | 11p15.5 |
|---|
| Swiss-Prot Accession | P07101 |
|---|---|
| P78428 | |
| Q0PWM3 | |
| Q0PWM2 | |
| P24529 | |
| P04177 | |
| B7ZL70 | |
| B7ZL73 | |
| Q15585 | |
| Q15588 | |
| Q15589 | |
| Q2M3B4 | |
| O43816 | |
| Q15587 | |
| Q16846 | |
| Q6XS77 | |
| Q7KZ36 | |
| Q7KZ38 | |
| Q7KZ39 | |
| Q7KZ44 | |
| Q8IZE1 | |
| Q8IZE2 | |
| Q8IZQ6 | |
| Q8IZQ7 | |
| Q9NP14 | |
| Q9UQ57 | |
| Q3UTB3 | |
| Q91ZN2 | |
| P97904 | |
| Q78E18 |
| PIR ID | JN0068 |
|---|---|
| A30002 | |
| A00510 |
| Unigene ID | Hs.435609 |
|---|---|
| Mm.1292 | |
| Rn.11082 |
| KEGG ID | hsa:7054 |
|---|---|
| mmu:21823 | |
| rno:25085 |
| Swiss-Prot ID | TY3H_MOUSE |
|---|---|
| TY3H_HUMAN | |
| TY3H_RAT | |
| B7ZL70_HUMAN | |
| P78428_HUMAN |
| EC Number | 1.14.16.2 |
|---|
| Ensembl ID | ENSG00000180176 |
|---|---|
| ENSP00000325951 | |
| ENST00000352909 | |
| ENSP00000370571 | |
| ENST00000381178 | |
| ENSP00000370567 | |
| ENST00000381175 | |
| ENSP00000328814 | |
| ENST00000333684 | |
| ENSMUSG00000000214 | |
| ENSMUSP00000000219 | |
| ENSMUST00000000219 | |
| ENSMUSP00000101549 | |
| ENSMUST00000105929 | |
| ENSRNOG00000020410 | |
| ENSRNOP00000027682 | |
| ENSRNOT00000027682 |
| Homologene ID | 307 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 98735 |
|---|
| RGD ID | 3853 |
|---|
| MedScan ID | 7054 |
|---|
| IPI ID | IPI00010178 |
|---|---|
| IPI00218275 | |
| IPI00218276 | |
| IPI00398179 | |
| IPI00217988 | |
| IPI00873437 | |
| IPI00873432 | |
| IPI00878515 | |
| IPI00878304 | |
| IPI00138131 | |
| IPI00831270 | |
| IPI00831043 | |
| IPI00880254 | |
| IPI00880391 | |
| IPI00881265 | |
| IPI00193259 |