| URN | urn:agi-llid:7054 |
|---|---|
| Connectivity | 555 |
| Name | Th |
| Description | tyrosine hydroxylase |
| Notes | The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq] |
| Pathway | epinephrine biosynthetic pathway |
|---|---|
| norepinephrine biosynthetic pathway | |
| Copy of 'epinephrine biosynthetic pathway' | |
| norepinephrine biosynthetic pathway | |
| dopamine biosynthetic pathway | |
| epinephrine biosynthetic pathway | |
| epinephrine biosynthetic pathway |
| GO Molecular Function | oxidoreductase activity |
|---|---|
| dopamine binding | |
| amino acid binding | |
| metal ion binding | |
| iron ion binding | |
| ferric iron binding | |
| ferrous iron binding | |
| monooxygenase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen | |
| tyrosine 3-monooxygenase activity |
| GO Cellular Component | synaptic vesicle |
|---|---|
| perikaryon | |
| neuron projection | |
| cytoplasm | |
| cytoplasmic vesicle | |
| cytosol | |
| mitochondrion | |
| smooth endoplasmic reticulum | |
| cytoplasmic vesicle membrane | |
| melanosome membrane | |
| nucleus | |
| internal side of plasma membrane | |
| terminal button | |
| axon |
| GO Biological Process | pigmentation |
|---|---|
| anatomical structure morphogenesis | |
| oxidation reduction | |
| response to stress | |
| mating behavior | |
| organ morphogenesis | |
| heart development | |
| eye photoreceptor cell development | |
| heart morphogenesis | |
| embryonic camera-type eye morphogenesis | |
| regulation of heart contraction | |
| memory | |
| learning | |
| visual perception | |
| synaptic transmission, dopaminergic | |
| aromatic amino acid family metabolic process | |
| neurotransmitter biosynthetic process | |
| catecholamine biosynthetic process | |
| norepinephrine biosynthetic process | |
| dopamine biosynthetic process | |
| epinephrine biosynthetic process | |
| dopamine biosynthetic process from tyrosine | |
| locomotory behavior | |
| response to hypoxia | |
| response to ethanol | |
| response to steroid hormone stimulus | |
| eating behavior | |
| protein homotetramerization |
| Ariadne Ontology | Aromatic amino acid metabolism |
|---|
| Group | Aromatic amino acid metabolism |
|---|---|
| pigmentation | |
| anatomical structure morphogenesis | |
| oxidation reduction | |
| response to stress | |
| mating behavior | |
| organ morphogenesis | |
| heart development | |
| eye photoreceptor cell development | |
| heart morphogenesis | |
| embryonic camera-type eye morphogenesis | |
| regulation of heart contraction | |
| memory | |
| learning | |
| visual perception | |
| synaptic transmission, dopaminergic | |
| aromatic amino acid family metabolic process | |
| neurotransmitter biosynthetic process | |
| catecholamine biosynthetic process | |
| norepinephrine biosynthetic process | |
| dopamine biosynthetic process | |
| epinephrine biosynthetic process | |
| dopamine biosynthetic process from tyrosine | |
| locomotory behavior | |
| response to hypoxia | |
| response to ethanol | |
| response to steroid hormone stimulus | |
| eating behavior | |
| protein homotetramerization | |
| oxidoreductase activity | |
| dopamine binding | |
| amino acid binding | |
| metal ion binding | |
| iron ion binding | |
| ferric iron binding | |
| ferrous iron binding | |
| monooxygenase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen | |
| tyrosine 3-monooxygenase activity | |
| synaptic vesicle | |
| perikaryon | |
| neuron projection | |
| cytoplasm | |
| cytoplasmic vesicle | |
| cytosol | |
| mitochondrion | |
| smooth endoplasmic reticulum | |
| cytoplasmic vesicle membrane | |
| melanosome membrane | |
| nucleus | |
| internal side of plasma membrane | |
| terminal button | |
| axon |
| MedScan ID | 7054 |
|---|
| Hugo ID | 11782 |
|---|
| Human chromosome position | 11p15.5 |
|---|
| LocusLink ID | 7054 |
|---|---|
| 21823 | |
| 25085 |
| Alias | TYH |
|---|---|
| DYT14 | |
| DYT5b | |
| tyrosine 3-monooxygenase | |
| dystonia 14 | |
| tyrosine 3-hydroxylase | |
| OTTMUSP00000020341 | |
| The | |
| LOC90736 | |
| L-tyrosine hydroxylase | |
| L-tyrosine hydroxylases | |
| OTTHUMP00000011225 | |
| OTTHUMP00000011226 | |
| tyrosine hydroxylase |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 191290 |
|---|---|
| 605407 |
| Mouse chromosome position | 7 69.2 cM |
|---|
| GO ID | 0016597 |
|---|---|
| 0035240 | |
| 0008199 | |
| 0008198 | |
| 0046872 | |
| 0004511 | |
| 0009653 | |
| 0009072 | |
| 0042416 | |
| 0006585 | |
| 0042755 | |
| 0048596 | |
| 0042418 | |
| 0042462 | |
| 0007507 | |
| 0003007 | |
| 0007612 | |
| 0007626 | |
| 0007617 | |
| 0007613 | |
| 0042136 | |
| 0042421 | |
| 0009887 | |
| 0055114 | |
| 0043473 | |
| 0008016 | |
| 0045471 | |
| 0001666 | |
| 0048545 | |
| 0001963 | |
| 0007601 | |
| 0030424 | |
| 0005737 | |
| 0031410 | |
| 0005829 | |
| 0009898 | |
| 0033162 | |
| 0005739 | |
| 0043005 | |
| 0005634 | |
| 0043204 | |
| 0005790 | |
| 0008021 | |
| 0043195 | |
| 0005506 | |
| 0004497 | |
| 0016491 | |
| 0016714 | |
| 0042423 | |
| 0030659 | |
| 0051289 | |
| 0006950 | |
| 0005515 | |
| 0007268 |
| Rat chromosome position | 1q41 |
|---|
| Swiss-Prot Accession | P07101 |
|---|---|
| P78428 | |
| O43816 | |
| Q0PWM2 | |
| Q0PWM3 | |
| Q15587 | |
| Q16846 | |
| Q2M3B4 | |
| Q6XS77 | |
| Q7KZ36 | |
| Q7KZ38 | |
| Q7KZ39 | |
| Q7KZ44 | |
| Q8IZE1 | |
| Q8IZE2 | |
| Q8IZQ6 | |
| Q8IZQ7 | |
| Q9NP14 | |
| Q9UQ57 | |
| P24529 | |
| Q3UTB3 | |
| Q91ZN2 | |
| P04177 | |
| P97904 | |
| Q78E18 | |
| B7ZL70 | |
| Q15585 | |
| Q15588 | |
| Q15589 |
| PIR ID | A00510 |
|---|---|
| A30002 | |
| JN0068 |
| Unigene ID | Hs.435609 |
|---|---|
| Mm.1292 | |
| Rn.11082 |
| KEGG ID | hsa:7054 |
|---|---|
| mmu:21823 | |
| rno:25085 |
| EC Number | 1.14.16.2 |
|---|
| Swiss-Prot ID | TY3H_RAT |
|---|---|
| TY3H_HUMAN | |
| TY3H_MOUSE | |
| P78428_HUMAN | |
| B7ZL70_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00193259 |
|---|---|
| IPI00010178 | |
| IPI00218275 | |
| IPI00398179 | |
| IPI00922082 | |
| IPI00138131 | |
| IPI00218276 | |
| IPI00217988 | |
| IPI00873437 | |
| IPI00873432 | |
| IPI00878515 | |
| IPI00878304 | |
| IPI00831270 | |
| IPI00831043 | |
| IPI00880254 | |
| IPI00880391 | |
| IPI00881265 |
| Homologene ID | 307 |
|---|
| RGD ID | 3853 |
|---|
| MGI ID | 98735 |
|---|