| URN | urn:agi-llid:6571 |
|---|---|
| Connectivity | 90 |
| Name | Slc18A2 |
| Description | solute carrier family 18 (vesicular monoamine), member 2 |
| Notes | The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A1 (MIM 193002).[supplied by OMIM] |
| Pathway | Copy of 'epinephrine biosynthetic pathway' |
|---|---|
| norepinephrine biosynthetic pathway | |
| dopamine biosynthetic pathway | |
| epinephrine biosynthetic pathway | |
| epinephrine biosynthetic pathway |
| GO Molecular Function | amine transmembrane transporter activity |
|---|---|
| monoamine transmembrane transporter activity |
| GO Cellular Component | synaptic vesicle |
|---|---|
| membrane | |
| cell body | |
| cytoplasmic vesicle | |
| cytoplasmic vesicle membrane | |
| dense core granule | |
| membrane fraction | |
| integral to membrane | |
| integral to plasma membrane | |
| axon terminus |
| GO Biological Process | death |
|---|---|
| transmembrane transport | |
| post-embryonic development | |
| aging | |
| transport | |
| insulin secretion | |
| synaptic vesicle amine transport | |
| response to toxin | |
| locomotory behavior | |
| response to amphetamine | |
| neurotransmitter transport | |
| monoamine transport | |
| glucose homeostasis |
| Ariadne Ontology | Neurotransmitter loading |
|---|---|
| Other transport proteins |
| Group | Neurotransmitter loading |
|---|---|
| Other transport proteins | |
| death | |
| transmembrane transport | |
| post-embryonic development | |
| aging | |
| transport | |
| insulin secretion | |
| synaptic vesicle amine transport | |
| response to toxin | |
| locomotory behavior | |
| response to amphetamine | |
| neurotransmitter transport | |
| monoamine transport | |
| glucose homeostasis | |
| amine transmembrane transporter activity | |
| monoamine transmembrane transporter activity | |
| synaptic vesicle | |
| membrane | |
| cell body | |
| cytoplasmic vesicle | |
| cytoplasmic vesicle membrane | |
| dense core granule | |
| membrane fraction | |
| integral to membrane | |
| integral to plasma membrane | |
| axon terminus |
| MedScan ID | 6571 |
|---|
| Hugo ID | 10935 |
|---|
| Human chromosome position | 10q25 |
|---|
| LocusLink ID | 6571 |
|---|---|
| 214084 | |
| 25549 |
| Alias | SVAT |
|---|---|
| SVMT | |
| VAT2 | |
| VMAT2 | |
| MGC26538 | |
| MGC120477 | |
| MGC120478 | |
| synaptic vesicular amine transporter | |
| monoamine transporter | |
| vesicular amine transporter 2 | |
| vesicle monoamine/H+ antiporter | |
| solute carrier family 18 member 2 | |
| vesicle monoamine transporter type 2 | |
| monoamine neurotransmitter transporter | |
| MGC90556 | |
| 9330105E13 | |
| 1110037L13Rik | |
| vesicular monoamine transporter 2 | |
| MNAT | |
| solute carrier family 18, member 2 | |
| Solute carrier family 18 A2 (vesicular monoamine transporter 2) | |
| 1110037L13 | |
| AV329468 | |
| OTTHUMP00000020576 | |
| Slc18a2 | |
| solute carrier family 18 (vesicular monoamine), member 2 | |
| solute carrier family 18 (vesicular monoamine), member II | |
| solute carrier family 18 a2 | |
| solute carrier family 18, member II | |
| Synaptic vesicle amine transporter | |
| vesicle monoamine transporter type II | |
| Vesicular amine transporter II | |
| vesicular monoamine transporter II |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 193001 |
|---|
| Mouse chromosome position | 19 53.0 cM |
|---|
| GO ID | 0008504 |
|---|---|
| 0016265 | |
| 0007626 | |
| 0015844 | |
| 0006836 | |
| 0009791 | |
| 0001975 | |
| 0009636 | |
| 0055085 | |
| 0031410 | |
| 0030659 | |
| 0005887 | |
| 0016020 | |
| 0005624 | |
| 0005275 | |
| 0007568 | |
| 0042593 | |
| 0030073 | |
| 0006810 | |
| 0043679 | |
| 0044297 | |
| 0031045 | |
| 0016021 | |
| 0008021 | |
| 0015842 |
| Rat chromosome position | 1q55 |
|---|
| Swiss-Prot Accession | Q05940 |
|---|---|
| Q4G147 | |
| Q99870 | |
| Q8BRU6 | |
| Q66L40 | |
| Q01827 | |
| Q9QVP1 | |
| B2RC96 | |
| Q15876 | |
| Q5VW49 | |
| Q9H3P6 | |
| Q8CC55 | |
| D3DRC4 |
| PIR ID | A46374 |
|---|---|
| A49368 | |
| S29810 |
| Unigene ID | Hs.596992 |
|---|---|
| Mm.361919 | |
| Mm.479202 | |
| Rn.9686 |
| KEGG ID | hsa:6571 |
|---|---|
| mmu:214084 | |
| rno:25549 |
| Swiss-Prot ID | VMAT2_RAT |
|---|---|
| VMAT2_HUMAN | |
| VMAT2_MOUSE | |
| D3DRC4_HUMAN | |
| B2RC96_HUMAN |
| Cell Localization | Cytoplasmic vesicle membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00207117 |
|---|---|
| IPI00016759 | |
| IPI00224463 | |
| IPI00471470 |
| Homologene ID | 2298 |
|---|
| RGD ID | 3694 |
|---|
| MGI ID | 106677 |
|---|