| URN | urn:agi-llid:153 |
|---|---|
| Connectivity | 321 |
| Name | Adrb1 |
| Description | adrenergic, beta-1-, receptor |
| Notes | The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq] |
| Pathway | AdrenergicRb -> STAT3 signaling |
|---|---|
| epinephrine signaling pathway via adrenergic receptor beta | |
| adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway |
| GO Molecular Function | signal transducer activity |
|---|---|
| drug binding | |
| norepinephrine binding | |
| dopamine binding | |
| epinephrine binding | |
| PDZ domain binding | |
| receptor activity | |
| G-protein coupled receptor activity | |
| adrenoceptor activity | |
| beta-adrenergic receptor activity | |
| beta1-adrenergic receptor activity |
| GO Cellular Component | membrane |
|---|---|
| plasma membrane | |
| membrane fraction | |
| microsome | |
| integral to membrane | |
| integral to plasma membrane |
| GO Biological Process | brown fat cell differentiation |
|---|---|
| fear response | |
| negative regulation of multicellular organism growth | |
| heat generation | |
| diet induced thermogenesis | |
| positive regulation of the force of heart contraction by epinephrine-norepinephrine | |
| positive regulation of heart rate by epinephrine-norepinephrine | |
| regulation of synaptic plasticity | |
| vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure | |
| signal transduction | |
| activation of adenylate cyclase activity by G-protein signaling pathway | |
| activation of adenylate cyclase activity | |
| response to cold | |
| G-protein coupled receptor protein signaling pathway |
| Ariadne Ontology | GPCR-GsCR |
|---|---|
| Oncogenes |
| Group | GPCR-GsCR |
|---|---|
| Oncogenes | |
| brown fat cell differentiation | |
| fear response | |
| negative regulation of multicellular organism growth | |
| heat generation | |
| diet induced thermogenesis | |
| positive regulation of the force of heart contraction by epinephrine-norepinephrine | |
| positive regulation of heart rate by epinephrine-norepinephrine | |
| regulation of synaptic plasticity | |
| vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure | |
| signal transduction | |
| activation of adenylate cyclase activity by G-protein signaling pathway | |
| activation of adenylate cyclase activity | |
| response to cold | |
| G-protein coupled receptor protein signaling pathway | |
| signal transducer activity | |
| drug binding | |
| norepinephrine binding | |
| dopamine binding | |
| epinephrine binding | |
| PDZ domain binding | |
| receptor activity | |
| G-protein coupled receptor activity | |
| adrenoceptor activity | |
| beta-adrenergic receptor activity | |
| beta1-adrenergic receptor activity | |
| membrane | |
| plasma membrane | |
| membrane fraction | |
| microsome | |
| integral to membrane | |
| integral to plasma membrane |
| MedScan ID | 153 |
|---|
| Hugo ID | 285 |
|---|
| Human chromosome position | 10q24-q26 |
|---|
| LocusLink ID | 153 |
|---|---|
| 11554 | |
| 24925 |
| Alias | RHR |
|---|---|
| B1AR | |
| ADRB1R | |
| BETA1AR | |
| beta-1 adrenergic receptor | |
| beta-1 adrenoceptor | |
| beta-1 adrenoreceptor | |
| Adrb-1 | |
| beta-AR | |
| beta 1-AR | |
| cardiac beta adrenergic receptor | |
| RATB1AR | |
| adrenergic receptor, beta 1 | |
| beta 1-adrenergic receptor beta 1-AR | |
| 1700034I23 | |
| 1700034I23Rik | |
| ADRB I | |
| ADRB1 | |
| adrenergic receptor beta I | |
| adrenergic receptor beta-1 | |
| adrenergic, beta-1-, receptor | |
| adrenergic, beta-1-, receptors | |
| beta 1-like adrenergic receptor | |
| beta 1-like adrenergic receptors | |
| beta 1-like adrenoceptor | |
| beta 1-like adrenoceptors | |
| beta 1-selective adrenergic | |
| beta 1-selective adrenoceptor | |
| beta 1-specific adrenergic | |
| beta 1-specific adrenoceptor | |
| beta-1 adrenergic receptors | |
| beta-1 adrenoceptors | |
| beta1ARs | |
| cardiac beta adrenergic receptors | |
| cervical cancer oncogene 3 | |
| cervical cancer oncogene III | |
| HCBP6 | |
| hepatitis C virus core-binding protein 6 | |
| hepatitis C virus core-binding protein VI | |
| MGC2495 | |
| OTTHUMP00000020519 | |
| beta-1-adrenergic receptor | |
| RIKEN cDNA 1700034I23 gene | |
| RIKEN cDNA 4833415N24 gene | |
| adrenergic receptor, beta | |
| beta-ARs |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 109630 |
|---|---|
| 607276 |
| Mouse chromosome position | 19 51.0 cM |
|---|
| GO ID | 0004930 |
|---|---|
| 0030165 | |
| 0004939 | |
| 0004940 | |
| 0035240 | |
| 0008144 | |
| 0004872 | |
| 0007190 | |
| 0007189 | |
| 0050873 | |
| 0002024 | |
| 0042596 | |
| 0031649 | |
| 0040015 | |
| 0001996 | |
| 0001997 | |
| 0009409 | |
| 0002025 | |
| 0005887 | |
| 0005624 | |
| 0005792 | |
| 0005886 | |
| 0004935 | |
| 0051379 | |
| 0051380 | |
| 0004871 | |
| 0007186 | |
| 0007165 | |
| 0016021 | |
| 0016020 | |
| 0048167 | |
| 0005515 |
| Rat chromosome position | 1q55 |
|---|
| Swiss-Prot Accession | P08588 |
|---|---|
| B2RVY4 | |
| P34971 | |
| Q9CRR2 | |
| P18090 | |
| B0LPE2 | |
| Q5T5Y4 | |
| Q9UKG7 | |
| Q9UKG8 |
| PIR ID | S12591 |
|---|---|
| A39911 |
| Unigene ID | Hs.99913 |
|---|---|
| Mm.46797 | |
| Rn.87064 |
| KEGG ID | hsa:153 |
|---|---|
| mmu:11554 | |
| rno:24925 |
| Swiss-Prot ID | ADRB1_RAT |
|---|---|
| ADRB1_HUMAN | |
| B2RVY4_MOUSE |
| Cell Localization | Cell membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00188184 |
|---|---|
| IPI00029278 | |
| IPI00896588 | |
| IPI00556266 | |
| IPI00119827 |
| Homologene ID | 20171 |
|---|
| RGD ID | 2059 |
|---|
| MGI ID | 87937 |
|---|