| URN | urn:agi-Regulation:inout-urn:agi-llid:154:out-urn:agi-meshdis:Heart%20Failure::unknown |
|---|---|
| References | 23 |
| Connectivity | 2 |
| Effect | unknown |
| Original # of References | 17 |
| TextRef | info:pmid/11306600#abs:6 |
|---|---|
| PubYear | 2001 |
| MedlineTA | J Clin Invest |
| Organ | Heart |
| MedLine Reference | 11306600:5 |
| Sentence | High-level overexpression of the beta(2)AR caused rapidly progressive cardiac failure in this model. |
| CellType | Myocytes, Cardiac |
| TextRef | info:pmid/19886995#abs:1 |
|---|---|
| PubYear | 2009 |
| MedlineTA | BMC Cardiovasc Disord |
| MedLine Reference | 19886995:0 |
| Sentence | Beta-2 adrenergic receptor gene polymorphisms Gln27Glu, Arg16Gly and Thr164Ile were suggested to have an effect in heart failure. |
| TextRef | info:pmid/2852942#abs:2 |
|---|---|
| PubYear | 1988 |
| MedlineTA | Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR |
| MedLine Reference | 2852942:1 |
| Sentence | The density of lymphocyte beta 2-adrenoceptors decreased significantly as heart failure progressed. |
| CellType | Lymphocytes |
| TextMods | 74: 'HF ' -> 'heart failure ' |
| TextRef | info:pmid/12796175#abs:1 |
|---|---|
| PubYear | 2003 |
| MedlineTA | Chest |
| MedLine Reference | 12796175:0 |
| Sentence | Recent studies suggest that myocardial beta(2)-adrenoceptors may be important in chronic heart failure. |
| Tissue | Myocardium |
| TextRef | info:pmid/10571539#abs:1 |
|---|---|
| PubYear | 1999 |
| MedlineTA | Circ Res |
| Organ | Heart |
| MedLine Reference | 10571539:0 |
| Sentence | Cardiac beta(2)-adrenergic receptor (beta(2)AR) overexpression is a potential contractile therapy for heart failure. |
| TextRef | info:pmid/11408541#abs:10 |
|---|---|
| PubYear | 2001 |
| MedlineTA | J Pharmacol Exp Ther |
| MedLine Reference | 11408541:9 |
| Sentence | In conclusion, beta2-AR activation stimulates L-type Ca2+ channels and increases I(Ca,L) in both normal and heart failure myocytes. |
| CellType | Muscle Cells |
| TextMods | 108: 'HF ' -> 'heart failure ' |
| TextRef | info:pmid/12933684#abs:7 |
|---|---|
| PubYear | 2003 |
| MedlineTA | Endocrinology |
| Organ | Heart |
| MedLine Reference | 12933684:6 |
| Sentence | In conclusion, cardiac beta(2)-beta(2)-adrenergic receptor overexpression at a high level leads to cardiomyopathy and heart failure with aging. |
| TextMods | 31: 'AR ' -> 'beta(2)-adrenergic receptor ' |
| TextRef | info:pmid/12954981#abs:2 |
|---|---|
| PubYear | 2003 |
| MedlineTA | Proc Natl Acad Sci U S A |
| MedLine Reference | 12954981:1 |
| Sentence | In addition to regulating cardiac rate and contractility, beta1 beta2-adrenergic receptors and beta2 beta2-adrenergic receptors may play different roles in the pathogenesis of heart failure. |
| TextMods | 63: 'AR ' -> 'beta2-adrenergic receptors ' 99: 'AR ' -> 'beta2-adrenergic receptors ' |
| TextRef | info:pmid/18467626#abs:7 |
|---|---|
| PubYear | 2008 |
| MedlineTA | Circ Res |
| Organ | Left ventricular |
| MedLine Reference | 18467626:6 |
| Sentence | Although total beta-AR expression was reduced by 47% in heart failure rabbit left ventricle, beta(2)-AR number was unchanged, indicating more potent beta(2)-AR-dependent sarcoplasmic reticulum Ca uptake and arrhythmogenesis in heart failure. |
| Organism | Oryctolagus cuniculus |
| TextMods | 56: 'HF ' -> 'heart failure ' 170: 'SR ' -> 'sarcoplasmic reticulum ' 227: 'HF' -> 'heart failure' |
| TextRef | info:pmid/15451518#abs:5 |
|---|---|
| PubYear | 2004 |
| MedlineTA | Trends Cardiovasc Med |
| MedLine Reference | 15451518:4 |
| Sentence | This review summarizes the extensive in vivo animal model experimentation that supports the still-controversial hypothesis that increasing the myocardial density of beta(2)-ARs or, more effectively, inhibiting the activity of the beta-adrenergic receptor kinase (also referred to as G-protein-coupled receptor kinase 2), represent potential novel therapeutic strategies for heart failure. |
| TextMods | 230: 'betaAR ' -> 'beta-adrenergic receptor ' 374: 'HF' -> 'heart failure' |
| Tissue | Myocardium |
| TextRef | info:pmid/2554871#abs:6 |
|---|---|
| PubYear | 1989 |
| MedlineTA | Basic Res Cardiol |
| Organ | Heart |
| MedLine Reference | 2554871:5 |
| Sentence | While a decrease in cardiac beta-adrenoceptor function appears to be a general phenomenon in all kinds of heart failure, it is not always due to a selective reduction in cardiac beta 1-adrenoceptors: in mitral valve disease both cardiac beta 1- and beta 2-adrenoceptors decline concomitantly in relation to the degree of heart failure. |
| TextRef | info:pmid/9788966#abs:2 |
|---|---|
| PubYear | 1998 |
| MedlineTA | J Clin Invest |
| Organ | Heart Ventricle |
| MedLine Reference | 9788966:1 |
| Sentence | Because dysfunctional betaARs play a role in the pathogenesis of the failing ventricle, we tested the hypothesis that beta2AR polymorphisms alter the outcome of congestive heart failure. 259 patients with NYHA functional class II-IV heart failure due to ischemic or dilated cardiomyopathy were genotyped and prospectively followed, with the endpoint defined as death or cardiac transplantation. |
| TextRef | info:pmid/11110761#body:188 |
|---|---|
| PubYear | 2000 |
| MedlineTA | Circ Res |
| MedLine Reference | 11110761:1187 |
| Sentence | The Ile 164 β2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure. |
| TextRef | info:pmid/14573761#body:44 |
|---|---|
| PubYear | 2003 |
| MedlineTA | Mol Pharmacol |
| Organ | Heart |
| MedLine Reference | 14573761:1043 |
| Sentence | Thus, beta2-AR polymorphisms that exhibit abnormal receptor-effector coupling or pattern of desensitization modify the prognosis of patients with congestive heart failure (Liggett et al., 1998) and the exercise capacity in patients with heart failure (Wagoner et al., 2000). |
| Tissue | Myocardium |
| TextRef | info:pmid/11040034#body:238 |
|---|---|
| PubYear | 2000 |
| MedlineTA | Mol Pharmacol |
| Organ | Heart |
| MedLine Reference | 11040034:1237 |
| Sentence | In addition, cardiac transgenic overexpression of β1-β2-adrenergic receptor by 5- to 15-fold in mice leads to marked myocyte hypertrophy, accompanied by fibrosis within a few weeks after birth and heart failure within a few months (Engelhardt et al., 1999). |
| TextMods | 54: 'AR ' -> 'β2-adrenergic receptor ' |
| TextRef | info:pmid/10785504#body:230 |
|---|---|
| PubYear | 2000 |
| MedlineTA | Circ Res |
| Organ | Blood Vessels |
| MedLine Reference | 10785504:1229 |
| Sentence | On the basis of these findings and our in vitro and transgenic results, it appears that β2AR polymorphisms have a significant modifying effect in heart failure. β2AR genotyping may thus be a useful test in the clinical evaluation of patients with heart failure, providing a genetic basis for altering drug therapy or early listing for transplantation. *. |
| TextMods | 147: 'HF' -> 'heart failure' 249: 'HF' -> 'heart failure' |
| TextRef | info:pmid/10581327#body:672 |
|---|---|
| PubYear | 1999 |
| MedlineTA | Pharmacol Rev |
| Organ | Heart |
| MedLine Reference | 10581327:1671 |
| Sentence | The failure of overexpression of β2-adrenoceptors to induce heart failure in the mouse is possibly due to the fact that this receptor subtype has, under normal conditions, no functional importance in the mouse heart (in contrast to the human heart; seePresence and Function of Receptor Subtypes in Human Heart. C1. β1- and β2-Adrenoceptors). |
| Organism | Mus musculus |
| TextRef | info:pmid/18615004#abs:1 |
|---|---|
| MedLine Reference | 18615004:0 |
| Sentence | Numerous studies have demonstrated that beta(1)- and beta(2)-adrenergic receptor gene (ADRB1 and ADRB2) variants influence cardiovascular risk and beta-blocker responses in hypertension and heart failure. |
| TextRef | info:pmid/1325108#abs:1 |
|---|---|
| Organ | Heart |
| MedLine Reference | 1325108:0 |
| Sentence | In 100 patients 12 to 60 months after cardiac transplantation, the influence of transplant coronary vasculopathy and of the pretransplantation disease (end-stage heart failure caused by coronary artery disease or dilated cardiomyopathy) on the beta-adrenergic receptor (AR) numbers and beta 1/beta 2-AR ratio of right ventricular biopsies was determined. |
| TextRef | info:pmid/9835617#cont:412 |
|---|---|
| MedLine Reference | 9835617:10411 |
| Sentence | Walsh(1998)The Ile164 ß 2 adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure. |
| Journal | J Clin Invest |
| Journal Reference | v102 i11 p1927 |
| Journal Link | http://www.jci.org/cgi/content/full/102/11/1927 |
| TextRef | info:pmid/18323528#cont:229 |
|---|---|
| MedLine Reference | 18323528:10228 |
| Sentence | The Ile164 beta2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure. |
| Journal | Circulation Res |
| Journal Reference | v102 i8 p986 |
| Journal Link | http://circres.ahajournals.org/cgi/content/full/102/8/986 |
| TextRef | info:pmid/16239589#cont:253 |
|---|---|
| Organ | Heart |
| MedLine Reference | 16239589:10252 |
| Sentence | The Ile164 beta2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure. |
| CellType | myocyte |
| Journal | Circulation Res |
| Journal Reference | v97 i11 p1182 |
| Journal Link | http://circres.ahajournals.org/cgi/content/full/97/11/1182 |
| TextRef | info:pmid/14573761#cont:20 |
|---|---|
| Organ | Heart |
| MedLine Reference | 14573761:10019 |
| Sentence | Thus, beta2-AR polymorphisms that exhibit abnormal receptor-effector coupling or pattern of desensitization modify the prognosis of patients with congestive heart failure (Liggett et al., 1998 ) and the exercise capacity in patients with heart failure (Wagoner et al., 2000 ). |
| Journal | Mol. Pharm |
| Journal Reference | v64 i5 p1117 |
| Journal Link | http://molpharm.aspetjournals.org/cgi/content/full/64/5/1117 |