| URN | urn:agi-llid:153 |
|---|---|
| Connectivity | 373 |
| Name | Adrb1 |
| Description | adrenergic, beta-1-, receptor |
| Notes | The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq] |
| Pathway | AdrenergicRb -> STAT3 signaling |
|---|---|
| epinephrine signaling pathway via adrenergic receptor beta | |
| adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway |
| Ariadne Ontology | Oncogenes |
|---|---|
| GPCR-GsCR |
| GO Molecular Function | protein binding |
|---|---|
| drug binding | |
| norepinephrine binding | |
| dopamine binding | |
| epinephrine binding | |
| PDZ domain binding | |
| signal transducer activity | |
| receptor activity | |
| G-protein coupled receptor activity | |
| adrenoceptor activity | |
| beta1-adrenergic receptor activity |
| GO Cellular Component | membrane |
|---|---|
| membrane fraction | |
| microsome | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane |
| GO Biological Process | negative regulation of multicellular organism growth |
|---|---|
| diet induced thermogenesis | |
| positive regulation of heart rate by epinephrine-norepinephrine | |
| positive regulation of the force of heart contraction by epinephrine-norepinephrine | |
| signal transduction | |
| regulation of synaptic plasticity | |
| activation of adenylate cyclase activity by G-protein signaling pathway | |
| G-protein coupled receptor protein signaling pathway | |
| heat generation | |
| vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure | |
| brown fat cell differentiation | |
| fear response | |
| response to cold |
| Group | Oncogenes |
|---|---|
| GPCR-GsCR | |
| membrane | |
| membrane fraction | |
| microsome | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| protein binding | |
| drug binding | |
| norepinephrine binding | |
| dopamine binding | |
| epinephrine binding | |
| PDZ domain binding | |
| signal transducer activity | |
| receptor activity | |
| G-protein coupled receptor activity | |
| adrenoceptor activity | |
| beta1-adrenergic receptor activity | |
| negative regulation of multicellular organism growth | |
| diet induced thermogenesis | |
| positive regulation of heart rate by epinephrine-norepinephrine | |
| positive regulation of the force of heart contraction by epinephrine-norepinephrine | |
| signal transduction | |
| regulation of synaptic plasticity | |
| activation of adenylate cyclase activity by G-protein signaling pathway | |
| G-protein coupled receptor protein signaling pathway | |
| heat generation | |
| vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure | |
| brown fat cell differentiation | |
| fear response | |
| response to cold |
| Hugo ID | 285 |
|---|
| Human chromosome position | 10q24-q26 |
|---|
| LocusLink ID | 153 |
|---|---|
| 11554 | |
| 24925 |
| Alias | RHR |
|---|---|
| B1AR | |
| ADRB1R | |
| BETA1AR | |
| beta-1-adrenergic receptor | |
| OTTHUMP00000020519 | |
| Adrb-1 | |
| beta-AR | |
| adrenergic receptor, beta 1 | |
| beta 1-AR | |
| cardiac beta adrenergic receptor | |
| RATB1AR | |
| adrenergic, beta-1-, receptor | |
| beta 1-adrenergic receptor beta 1-AR | |
| ADRB1 | |
| Beta-1 adrenergic receptor | |
| Beta-1 adrenoceptor | |
| cervical cancer oncogene 3 | |
| HCBP6 | |
| hepatitis C virus core-binding protein 6 | |
| RIKEN cDNA 1700034I23 gene | |
| RIKEN cDNA 4833415N24 gene | |
| 1700034I23Rik | |
| adrenergic receptor, beta | |
| hepatitis C virus core-binding protein VI | |
| cervical cancer oncogene III | |
| adrenergic receptor beta I | |
| ADRB I | |
| adrenergic receptor beta-1 | |
| beta-ARs | |
| MGC2495 | |
| cardiac beta adrenergic receptors | |
| adrenergic, beta-1-, receptors | |
| Beta-1 adrenergic receptors |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 109630 |
|---|---|
| 607276 |
| Swiss-Prot Accession | P08588 |
|---|---|
| B2RVY4 | |
| P34971 | |
| Q9CRR2 | |
| P18090 |
| Unigene ID | Hs.99913 |
|---|---|
| Mm.46797 | |
| Rn.87064 |
| KEGG ID | hsa:153 |
|---|---|
| rno:24925 |
| Swiss-Prot ID | ADRB1_RAT |
|---|---|
| B2RVY4_MOUSE |
| Cell Localization | Plasma membrane |
|---|
| GO ID | 0004930 |
|---|---|
| 0004940 | |
| 0005515 | |
| 0004872 | |
| 0007186 | |
| 0007189 | |
| 0050873 | |
| 0002024 | |
| 0042596 | |
| 0031649 | |
| 0040015 | |
| 0001996 | |
| 0001997 | |
| 0009409 | |
| 0007165 | |
| 0002025 | |
| 0005887 | |
| 0005624 | |
| 0005886 | |
| 0004935 | |
| 0004871 | |
| 0016021 | |
| 0016020 | |
| 0030165 | |
| 0035240 | |
| 0008144 | |
| 0051379 | |
| 0051380 | |
| 0048167 | |
| 0005792 |
| IPI ID | IPI00029278 |
|---|---|
| IPI00556266 | |
| IPI00119827 | |
| IPI00896588 | |
| IPI00188184 |
| Mouse chromosome position | 19 51.0 cM |
|---|
| Homologene ID | 20171 |
|---|
| MGI ID | 87937 |
|---|
| Rat chromosome position | 1q55 |
|---|
| RGD ID | 2059 |
|---|