| URN | urn:agi-llid:156 |
|---|---|
| Connectivity | 366 |
| Name | Adrbk1 |
| Description | adrenergic, beta, receptor kinase 1 |
| Notes | The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq] |
| Pathway | epinephrine signaling pathway via adrenergic receptor beta |
|---|
| Ariadne Ontology | GRK |
|---|
| GO Molecular Function | protein binding |
|---|---|
| nucleotide binding | |
| ATP binding | |
| beta-2 adrenergic receptor binding | |
| transferase activity | |
| kinase activity | |
| protein kinase activity | |
| beta-adrenergic receptor kinase activity | |
| protein serine-threonine kinase activity | |
| G-protein coupled receptor kinase activity | |
| signal transducer activity | |
| receptor activity |
| GO Cellular Component | synapse |
|---|---|
| membrane | |
| soluble fraction | |
| membrane fraction | |
| dendritic shaft | |
| dendritic spine | |
| axon | |
| cytoplasm | |
| caveola |
| GO Biological Process | negative regulation of G-protein coupled receptor protein signaling pathway |
|---|---|
| desensitization of G-protein coupled receptor protein signaling pathway | |
| negative regulation of the force of heart contraction by chemical signal | |
| negative regulation of striated muscle contraction | |
| positive regulation of catecholamine secretion | |
| signal transduction | |
| G-protein coupled receptor protein signaling pathway | |
| muscarinic acetylcholine receptor signaling pathway | |
| tachykinin receptor signaling pathway | |
| regulation of the force of heart contraction | |
| peptidyl-serine phosphorylation | |
| peptidyl-threonine phosphorylation | |
| protein amino acid phosphorylation | |
| phosphorylation | |
| aging | |
| heart development | |
| cardiac muscle contraction | |
| response to oxidative stress | |
| response to organic cyclic substance | |
| response to hydrogen peroxide |
| Group | GRK |
|---|---|
| synapse | |
| membrane | |
| soluble fraction | |
| membrane fraction | |
| dendritic shaft | |
| dendritic spine | |
| axon | |
| cytoplasm | |
| caveola | |
| protein binding | |
| nucleotide binding | |
| ATP binding | |
| beta-2 adrenergic receptor binding | |
| transferase activity | |
| kinase activity | |
| protein kinase activity | |
| beta-adrenergic receptor kinase activity | |
| protein serine-threonine kinase activity | |
| G-protein coupled receptor kinase activity | |
| signal transducer activity | |
| receptor activity | |
| negative regulation of G-protein coupled receptor protein signaling pathway | |
| desensitization of G-protein coupled receptor protein signaling pathway | |
| negative regulation of the force of heart contraction by chemical signal | |
| negative regulation of striated muscle contraction | |
| positive regulation of catecholamine secretion | |
| signal transduction | |
| G-protein coupled receptor protein signaling pathway | |
| muscarinic acetylcholine receptor signaling pathway | |
| tachykinin receptor signaling pathway | |
| regulation of the force of heart contraction | |
| peptidyl-serine phosphorylation | |
| peptidyl-threonine phosphorylation | |
| protein amino acid phosphorylation | |
| phosphorylation | |
| aging | |
| heart development | |
| cardiac muscle contraction | |
| response to oxidative stress | |
| response to organic cyclic substance | |
| response to hydrogen peroxide |
| Hugo ID | 289 |
|---|
| Human chromosome position | 11q13.1 |
|---|
| LocusLink ID | 156 |
|---|---|
| 110355 | |
| 25238 |
| Alias | GRK2 |
|---|---|
| BARK1 | |
| FLJ16718 | |
| BETA-ARK1 | |
| beta-adrenergic receptor kinase 1 | |
| Bark-1 | |
| Adrbk-1 | |
| betaARK1 | |
| beta ARK | |
| beta ARK1 | |
| beta-AR kinase-1 | |
| beta-adrenergic receptor kinase-1 | |
| GRK-2 | |
| adrenergic receptor kinase, beta 1 | |
| G-protein-coupled receptor kinase 2 | |
| beta-adrenergic receptor kinase 1 beta ARK1 | |
| adrenergic receptor kinase, beta I | |
| BARK I | |
| Adrbk1 | |
| Beta-ARK-1 | |
| G- protein coupled receptor kinase 2 | |
| adrenergic receptor kinase, beta | |
| adrenergic, beta, receptor kinase | |
| G- protein coupled receptor kinase II | |
| Beta-adrenergic receptor kinase I | |
| adrenergic, beta, receptor kinase 1 | |
| adrenergic, beta, receptor kinase I | |
| beta-AR kinase I | |
| Beta-ARK I | |
| Adrbk I | |
| adrenergic receptor kinase | |
| g-protein-linked receptor kinase | |
| BARK | |
| beta adrenergic receptor kinase 1 | |
| Adrbk1s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 109635 |
|---|
| Swiss-Prot Accession | P25098 |
|---|---|
| Q59F73 | |
| Q7TS64 | |
| Q3U1V3 | |
| Q3U5J8 | |
| Q99MK8 | |
| P26817 |
| Unigene ID | Hs.83636 |
|---|---|
| Mm.254144 | |
| Rn.13010 |
| KEGG ID | hsa:156 |
|---|---|
| rno:25238 |
| EC Number | 2.7.11.15 |
|---|
| Swiss-Prot ID | ARBK1_HUMAN |
|---|---|
| ARBK1_RAT | |
| Q7TS64_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0005524 |
|---|---|
| 0004703 | |
| 0047696 | |
| 0000166 | |
| 0005515 | |
| 0004871 | |
| 0016740 | |
| 0060048 | |
| 0002029 | |
| 0007507 | |
| 0007213 | |
| 0045988 | |
| 0003108 | |
| 0018105 | |
| 0033605 | |
| 0002026 | |
| 0007165 | |
| 0007217 | |
| 0005737 | |
| 0016020 | |
| 0005625 | |
| 0016301 | |
| 0004672 | |
| 0004674 | |
| 0004872 | |
| 0007186 | |
| 0018107 | |
| 0016310 | |
| 0006468 | |
| 0031698 | |
| 0007568 | |
| 0045744 | |
| 0042542 | |
| 0014070 | |
| 0006979 | |
| 0030424 | |
| 0005901 | |
| 0043198 | |
| 0043197 | |
| 0005624 | |
| 0045202 |
| IPI ID | IPI00012497 |
|---|---|
| IPI00555929 | |
| IPI00747929 | |
| IPI00320687 | |
| IPI00469231 | |
| IPI00196987 |
| Mouse chromosome position | 19 3.0 cM |
|---|
| Homologene ID | 1223 |
|---|
| MGI ID | 87940 |
|---|
| Rat chromosome position | 1q42 |
|---|
| RGD ID | 2062 |
|---|