Protein Arrb2

URN	urn:agi-llid:409
Connectivity	257
Name	Arrb2
Description	arrestin, beta 2
Notes	Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq]

Pathway	epinephrine signaling pathway via adrenergic receptor beta

GO Molecular Function	protein binding
	clathrin binding
	protein domain specific binding
	G-protein-coupled receptor binding

GO Biological Process	response to stimulus
	desensitization of G-protein coupled receptor protein signaling pathway by arrestin
	signal transduction
	regulation of G-protein coupled receptor protein signaling pathway
	regulation of cAMP biosynthetic process
	regulation of cAMP catabolic process
	regulation of protein amino acid phosphorylation
	G-protein coupled receptor protein signaling pathway
	transforming growth factor beta receptor signaling pathway
	endocytosis
	receptor internalization
	sensory perception

Group	intracellular
	cytoplasm
	cytoplasmic vesicle
	nucleus
	plasma membrane
	postsynaptic membrane
	protein binding
	clathrin binding
	protein domain specific binding
	G-protein-coupled receptor binding
	response to stimulus
	desensitization of G-protein coupled receptor protein signaling pathway by arrestin
	signal transduction
	regulation of G-protein coupled receptor protein signaling pathway
	regulation of cAMP biosynthetic process
	regulation of cAMP catabolic process
	regulation of protein amino acid phosphorylation
	G-protein coupled receptor protein signaling pathway
	transforming growth factor beta receptor signaling pathway
	endocytosis
	receptor internalization
	sensory perception

Hugo ID	712

Human chromosome position	17p13

OMIM ID	107941

Mouse chromosome position	11 45.0 cM

Homologene ID	3183

MGI ID	99474

Rat chromosome position	10q24

RGD ID	2157