| URN | urn:agi-llid:154 |
|---|---|
| Connectivity | 477 |
| Name | Adrb2 |
| Description | adrenergic, beta-2-, receptor, surface |
| Notes | This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq] |
| Pathway | AdrenergicRb -> STAT3 signaling |
|---|---|
| AdrenergicRb -> CREB signaling | |
| epinephrine signaling pathway via adrenergic receptor beta | |
| adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway |
| Ariadne Ontology | GPCR-GsCR |
|---|
| GO Molecular Function | potassium channel regulator activity |
|---|---|
| protein binding | |
| drug binding | |
| norepinephrine binding | |
| dopamine binding | |
| epinephrine binding | |
| protein complex binding | |
| adenylate cyclase binding | |
| protein homodimerization activity | |
| PDZ domain binding | |
| signal transducer activity | |
| receptor activity | |
| G-protein coupled receptor activity | |
| adrenoceptor activity | |
| beta2-adrenergic receptor activity |
| GO Cellular Component | intracellular part |
|---|---|
| membrane | |
| apical plasma membrane | |
| membrane fraction | |
| microsome | |
| dendrite | |
| axon | |
| endosome | |
| lysosome | |
| nucleus | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| caveola | |
| sarcolemma | |
| receptor complex |
| GO Biological Process | activation of transmembrane receptor protein tyrosine kinase activity |
|---|---|
| desensitization of G-protein coupled receptor protein signaling pathway by arrestin | |
| negative regulation of ossification | |
| negative regulation of multicellular organism growth | |
| negative regulation of smooth muscle contraction | |
| negative regulation of inflammatory response | |
| negative regulation of calcium ion transport via voltage-gated calcium channel activity | |
| positive regulation of cell proliferation | |
| positive regulation of MAPKKK cascade | |
| positive regulation of apoptosis | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of bone mineralization | |
| positive regulation of skeletal muscle growth | |
| diet induced thermogenesis | |
| positive regulation of heart contraction | |
| positive regulation of vasodilation | |
| positive regulation of potassium ion transport | |
| positive regulation of sodium ion transport | |
| signal transduction | |
| activation of adenylate cyclase activity by G-protein signaling pathway | |
| activation of MAPK activity | |
| G-protein coupled receptor protein signaling pathway | |
| protein kinase cascade | |
| regulation of sodium ion transport | |
| regulation of sensory perception of pain | |
| bone resorption | |
| heat generation | |
| vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure | |
| regulation of systemic arterial blood pressure by norepinephrine-epinephrine | |
| receptor-mediated endocytosis | |
| brown fat cell differentiation | |
| endosome to lysosome transport | |
| response to cold |
| Group | GPCR-GsCR |
|---|---|
| intracellular part | |
| membrane | |
| apical plasma membrane | |
| membrane fraction | |
| microsome | |
| dendrite | |
| axon | |
| endosome | |
| lysosome | |
| nucleus | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| caveola | |
| sarcolemma | |
| receptor complex | |
| potassium channel regulator activity | |
| protein binding | |
| drug binding | |
| norepinephrine binding | |
| dopamine binding | |
| epinephrine binding | |
| protein complex binding | |
| adenylate cyclase binding | |
| protein homodimerization activity | |
| PDZ domain binding | |
| signal transducer activity | |
| receptor activity | |
| G-protein coupled receptor activity | |
| adrenoceptor activity | |
| beta2-adrenergic receptor activity | |
| activation of transmembrane receptor protein tyrosine kinase activity | |
| desensitization of G-protein coupled receptor protein signaling pathway by arrestin | |
| negative regulation of ossification | |
| negative regulation of multicellular organism growth | |
| negative regulation of smooth muscle contraction | |
| negative regulation of inflammatory response | |
| negative regulation of calcium ion transport via voltage-gated calcium channel activity | |
| positive regulation of cell proliferation | |
| positive regulation of MAPKKK cascade | |
| positive regulation of apoptosis | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of bone mineralization | |
| positive regulation of skeletal muscle growth | |
| diet induced thermogenesis | |
| positive regulation of heart contraction | |
| positive regulation of vasodilation | |
| positive regulation of potassium ion transport | |
| positive regulation of sodium ion transport | |
| signal transduction | |
| activation of adenylate cyclase activity by G-protein signaling pathway | |
| activation of MAPK activity | |
| G-protein coupled receptor protein signaling pathway | |
| protein kinase cascade | |
| regulation of sodium ion transport | |
| regulation of sensory perception of pain | |
| bone resorption | |
| heat generation | |
| vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure | |
| regulation of systemic arterial blood pressure by norepinephrine-epinephrine | |
| receptor-mediated endocytosis | |
| brown fat cell differentiation | |
| endosome to lysosome transport | |
| response to cold |
| Hugo ID | 286 |
|---|
| Human chromosome position | 5q31-q32 |
|---|
| LocusLink ID | 154 |
|---|---|
| 11555 | |
| 24176 |
| Alias | BAR |
|---|---|
| B2AR | |
| ADRBR | |
| ADRB2R | |
| BETA2AR | |
| adrenergic, beta-2-, receptor, surface | |
| beta-2 adrenoceptor | |
| catecholamine receptor | |
| beta-2 adrenergic receptor | |
| Badm | |
| Gpcr7 | |
| Adrb-2 | |
| adrenergic receptor, beta 2 | |
| beta 2-AR | |
| beta 2-adrenoceptor | |
| Adrenergic beta 2- receptor surface | |
| catecholamine receptors | |
| beta-2 adrenergic receptors | |
| adrenergic receptor beta-2 | |
| ADRB2 | |
| Adrenergic, beta 2-, receptor, surface | |
| adrenergic receptor beta II | |
| LOC269028 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 109690 |
|---|---|
| 600807 | |
| 601665 |
| Swiss-Prot Accession | P07550 |
|---|---|
| Q53GA6 | |
| Q6GMT4 | |
| Q96EC3 | |
| Q9BYZ0 | |
| Q9UCZ0 | |
| Q8BH38 | |
| P18762 | |
| Q8K0V0 | |
| Q99P03 | |
| Q8VBU7 | |
| P10608 | |
| Q99P02 |
| Unigene ID | Hs.591251 |
|---|---|
| Mm.5598 | |
| Rn.10206 |
| KEGG ID | hsa:154 |
|---|---|
| rno:24176 |
| Swiss-Prot ID | ADRB2_HUMAN |
|---|---|
| Q8BH38_MOUSE | |
| Q8VBU7_RAT |
| Cell Localization | Plasma membrane |
|---|
| GO ID | 0004930 |
|---|---|
| 0008179 | |
| 0004941 | |
| 0008144 | |
| 0051380 | |
| 0015459 | |
| 0032403 | |
| 0042803 | |
| 0004872 | |
| 0007186 | |
| 0000187 | |
| 0007189 | |
| 0007171 | |
| 0045453 | |
| 0050873 | |
| 0002032 | |
| 0002024 | |
| 0008333 | |
| 0031649 | |
| 0051927 | |
| 0050728 | |
| 0040015 | |
| 0030279 | |
| 0045986 | |
| 0043410 | |
| 0043065 | |
| 0030501 | |
| 0008284 | |
| 0045823 | |
| 0048633 | |
| 0045944 | |
| 0045909 | |
| 0007243 | |
| 0006898 | |
| 0051930 | |
| 0002028 | |
| 0009409 | |
| 0002025 | |
| 0016324 | |
| 0030424 | |
| 0005901 | |
| 0030425 | |
| 0005768 | |
| 0005887 | |
| 0044424 | |
| 0005764 | |
| 0005624 | |
| 0005634 | |
| 0043235 | |
| 0042383 | |
| 0004935 | |
| 0005515 | |
| 0004871 | |
| 0001993 | |
| 0007165 | |
| 0016021 | |
| 0016020 | |
| 0005886 | |
| 0030165 | |
| 0035240 | |
| 0051379 | |
| 0043268 | |
| 0010765 | |
| 0005792 |
| IPI ID | IPI00465066 |
|---|---|
| IPI00221716 | |
| IPI00387188 | |
| IPI00192309 | |
| IPI00480783 |
| Mouse chromosome position | 18 34.0 cM |
|---|
| Homologene ID | 30948 |
|---|
| MGI ID | 87938 |
|---|
| Rat chromosome position | 18q12.1 |
|---|
| RGD ID | 2060 |
|---|