| URN | urn:agi-llid:23161 |
|---|---|
| Connectivity | 9 |
| Name | Snx13 |
| Description | sorting nexin 13 |
| Notes | This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking. [provided by RefSeq] |
| Pathway | epinephrine signaling pathway via adrenergic receptor beta |
|---|
| GO Molecular Function | protein binding |
|---|---|
| phosphoinositide binding | |
| signal transducer activity |
| GO Biological Process | negative regulation of signal transduction |
|---|---|
| cell communication | |
| transport | |
| protein transport |
| Group | protein binding |
|---|---|
| phosphoinositide binding | |
| signal transducer activity | |
| negative regulation of signal transduction | |
| cell communication | |
| transport | |
| protein transport |
| Hugo ID | 21335 |
|---|
| Human chromosome position | 7p21.1 |
|---|
| LocusLink ID | 23161 |
|---|---|
| 217463 | |
| 362731 |
| Alias | RGS-PX1 |
|---|---|
| KIAA0713 | |
| sorting nexin 13 | |
| rgs domain- and phox domain-containing protein | |
| mKIAA0713 | |
| RGS-PX I | |
| SNX13 | |
| LOC217463 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 606589 |
|---|
| Swiss-Prot Accession | B2RCI9 |
|---|---|
| Q9Y5W8 | |
| Q86XC4 | |
| Q9NSH0 | |
| Q3TCG6 | |
| Q3U457 | |
| Q3UG27 | |
| Q3V091 | |
| Q6NX82 | |
| Q6PHS6 | |
| Q80TT7 |
| Unigene ID | Hs.487648 |
|---|---|
| Mm.213991 | |
| Rn.30138 |
| KEGG ID | hsa:23161 |
|---|---|
| mmu:217463 | |
| rno:362731 |
| Swiss-Prot ID | SNX13_HUMAN |
|---|---|
| SNX13_MOUSE | |
| B2RCI9_HUMAN |
| GO ID | 0035091 |
|---|---|
| 0005515 | |
| 0004871 | |
| 0007154 | |
| 0009968 | |
| 0015031 | |
| 0006810 |
| IPI ID | IPI00396267 |
|---|---|
| IPI00478181 | |
| IPI00300112 | |
| IPI00120455 | |
| IPI00564081 | |
| IPI00870182 |
| Mouse chromosome position | 12 A3 |
|---|
| Homologene ID | 41011 |
|---|
| MGI ID | 2661416 |
|---|
| Rat chromosome position | 6q16 |
|---|
| RGD ID | 1309778 |
|---|