Ariadne Genomics Inc. epinephrine prompting stresses epinephrine receptor internalization receptor - G protein uncoupling Gnas G protein mediated signaling pathway via Galphas family beta-arrestin mediated signaling epinephrine biosynthetic pathway protein kinase A (PKA) signaling pathway cAMP --+> protein kinase A (PKA) signaling pathway cAMP G protein mediated signaling pathway via Galphas family --+> cAMP Snx13 ---| Gnas Adrb2 ---- epinephrine Adrb1 ---- epinephrine receptor - G protein uncoupling ---| G protein mediated signaling pathway via Galphas family Grk5 ---| Adrb2 Grk5 ---| Adrb1 Adrbk1 ---| Adrb2 Adrbk1 ---| Adrb1 Grk5 Adrbk1 Snx13 Adrb2 ---- Gnas Adrb1 ---- Gnas Adrb2 ---- Arrb1 Adrb2 ---- Arrb2 Adrb1 ---- Arrb2 Adrb1 ---- Arrb1 Adrb1 Adrb2 Arrb1 Arrb2 Arrb2 ---> beta-arrestin mediated signaling Arrb1 ---> beta-arrestin mediated signaling epinephrine prompting stresses ---> epinephrine epinephrine release