Elsevier Inc. DHT testosterone Ncoa2 Ncor2 Ar target genes Prostatic Neoplasms Ar target genes ---> prostate cancer pathway Ar chaperones non-steroid Ar antagonist Ar corepressors ---> Translocated Ar complex Ar coactivators Ar corepressors Ar ---- Ar antagonist Ar ---- non-steroid Ar Ar mutations Ar amplification Ar ---- Ar chaperones increased expression of steroidogenic genes ---> testosterone biosynthetic pathway testosterone reduction ---> testosterone biosynthetic pathway testosterone reduction Translocated Ar complex ---> Ar target genes Ar target genes ---> Prostatic Neoplasms Ar ---- DHT increased expression of steroidogenic genes Ar corepressors ---- Translocated Ar complex Ar coactivators ---- Translocated Ar complex Ar coactivators ---> Translocated Ar complex Ar ---> Translocated Ar complex Ar ---- testosterone testosterone biosynthetic pathway gene fusion events prostate cancer pathway gene fusion events ---> prostate cancer pathway gene fusion events ---> Prostatic Neoplasms Translocated Ar complex