| URN | urn:agi-llid:1588 |
|---|---|
| Connectivity | 511 |
| Name | Cyp19a1 |
| Description | cytochrome P450, family 19, subfamily A, polypeptide 1 |
| Notes | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants. [provided by RefSeq] |
| Pathway | estradiol biosynthetic pathway |
|---|---|
| aromatase inhibitor pathway | |
| estradiol biosynthetic pathway |
| GO Molecular Function | electron carrier activity |
|---|---|
| oxygen binding | |
| oxidoreductase activity | |
| heme binding | |
| metal ion binding | |
| iron ion binding | |
| monooxygenase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | |
| aromatase activity |
| GO Cellular Component | synaptic vesicle |
|---|---|
| membrane | |
| cytoplasm | |
| dendritic spine | |
| endoplasmic reticulum | |
| membrane fraction | |
| axon terminus |
| GO Biological Process | oxidation reduction |
|---|---|
| prostate gland growth | |
| androgen metabolic process | |
| estrogen biosynthetic process | |
| steroid biosynthetic process | |
| regulation of synapse structure and activity |
| Ariadne Ontology | Xenobiotic clearance |
|---|
| Group | Xenobiotic clearance |
|---|---|
| electron carrier activity | |
| oxidation reduction | |
| prostate gland growth | |
| androgen metabolic process | |
| estrogen biosynthetic process | |
| steroid biosynthetic process | |
| regulation of synapse structure and activity | |
| oxygen binding | |
| oxidoreductase activity | |
| heme binding | |
| metal ion binding | |
| iron ion binding | |
| monooxygenase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | |
| aromatase activity | |
| synaptic vesicle | |
| membrane | |
| cytoplasm | |
| dendritic spine | |
| endoplasmic reticulum | |
| membrane fraction | |
| axon terminus |
| MedScan ID | 1588 |
|---|
| Hugo ID | 2594 |
|---|
| Human chromosome position | 15q21.1 |
|---|
| LocusLink ID | 1588 |
|---|---|
| 13075 | |
| 25147 |
| Alias | ARO |
|---|---|
| ARO1 | |
| CPV1 | |
| CYAR | |
| CYP19 | |
| MGC104309 | |
| P-450AROM | |
| cytochrome P450 19A1 | |
| CYPXIX | |
| aromatase | |
| estrogen synthase | |
| OTTHUMP00000162543 | |
| OTTHUMP00000198350 | |
| estrogen synthetase | |
| cytochrome P-450AROM | |
| microsomal monooxygenase | |
| flavoprotein-linked monooxygenase | |
| cytochrome P450, subfamily XIX (aromatization of androgens) | |
| Ar | |
| ArKO | |
| Int5 | |
| Int-5 | |
| p450arom | |
| MGC124251 | |
| MGC124252 | |
| cytochrome P450, 19, aromatase | |
| Cyp19a | |
| cytochrome P450, subfamily 19 | |
| cytochrome P450 family 19 subfamily a | |
| ARO I | |
| aromatases | |
| CPV I | |
| CYP19A I | |
| CYP19A1 | |
| cytochrome P450 19 | |
| cytochrome P450 19 aromatase | |
| cytochrome P450 19A | |
| cytochrome P450 CYP19 | |
| cytochrome P45019 | |
| cytochrome P45019A | |
| cytochrome P45019A1 | |
| cytochrome P450XIX | |
| cytochrome P450XIX (aromatization of androgens) | |
| oestrogen synthase | |
| oestrogen synthetase | |
| P450 (CYP) 19A | |
| P450 (CYP) 19A1 | |
| P450 19A | |
| P450 19A1 | |
| P45019A | |
| P45019A1 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 107910 |
|---|---|
| 139300 |
| Mouse chromosome position | 9 31.0 cM |
|---|
| GO ID | 0070330 |
|---|---|
| 0009055 | |
| 0020037 | |
| 0046872 | |
| 0016712 | |
| 0019825 | |
| 0008209 | |
| 0055114 | |
| 0060736 | |
| 0006694 | |
| 0005783 | |
| 0016020 | |
| 0005624 | |
| 0005506 | |
| 0004497 | |
| 0016491 | |
| 0050803 | |
| 0043679 | |
| 0005737 | |
| 0043197 | |
| 0008021 | |
| 0006703 |
| Rat chromosome position | 8q23-q24 |
|---|
| Swiss-Prot Accession | P11511 |
|---|---|
| Q8TCA4 | |
| A8K6W3 | |
| Q05CU4 | |
| Q16449 | |
| Q45RG7 | |
| Q7Z471 | |
| Q8IYG4 | |
| Q8IYJ7 | |
| P28649 | |
| Q3ZAT3 | |
| P22443 | |
| Q16731 | |
| Q3B764 | |
| Q58FA0 |
| PIR ID | S13912 |
|---|---|
| A34451 |
| Unigene ID | Hs.260074 |
|---|---|
| Mm.5199 | |
| Mm.478781 | |
| Rn.21402 |
| KEGG ID | hsa:1588 |
|---|---|
| mmu:13075 | |
| rno:25147 |
| EC Number | 1.14.14.1 |
|---|
| Swiss-Prot ID | CP19A_MOUSE |
|---|---|
| CP19A_HUMAN | |
| Q8TCA4_HUMAN | |
| Q05CU4_HUMAN | |
| A8K6W3_HUMAN | |
| Q3ZAT3_MOUSE |
| Cell Localization | Membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00123174 |
|---|---|
| IPI00465065 | |
| IPI00792976 | |
| IPI00791258 | |
| IPI00879236 | |
| IPI00790666 | |
| IPI00792386 | |
| IPI00878829 | |
| IPI00878332 | |
| IPI00207135 |
| Homologene ID | 30955 |
|---|
| RGD ID | 2457 |
|---|
| MGI ID | 88587 |
|---|