| URN | urn:agi-llid:3293 |
|---|---|
| Connectivity | 21 |
| Name | Hsd17b3 |
| Description | hydroxysteroid (17-beta) dehydrogenase 3 |
| Notes | This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia. [provided by RefSeq] |
| Pathway | testosterone biosynthetic pathway - gth |
|---|---|
| Copy of 'testosterone biosynthetic pathway' | |
| testosterone biosynthetic pathway | |
| estradiol biosynthetic pathway | |
| testosterone biosynthetic pathway - Copy | |
| estradiol biosynthetic pathway | |
| testosterone biosynthetic pathway |
| GO Molecular Function | catalytic activity |
|---|---|
| oxidoreductase activity | |
| estradiol 17-beta-dehydrogenase activity | |
| testosterone 17-beta-dehydrogenase (NADP+) activity | |
| testosterone 17-beta-dehydrogenase activity |
| GO Cellular Component | microsome |
|---|
| GO Biological Process | metabolic process |
|---|---|
| oxidation reduction | |
| male genitalia development | |
| lipid biosynthetic process | |
| steroid biosynthetic process |
| Ariadne Ontology | Steroid metabolism |
|---|
| Group | Steroid metabolism |
|---|---|
| catalytic activity | |
| metabolic process | |
| oxidation reduction | |
| male genitalia development | |
| lipid biosynthetic process | |
| steroid biosynthetic process | |
| oxidoreductase activity | |
| estradiol 17-beta-dehydrogenase activity | |
| testosterone 17-beta-dehydrogenase (NADP+) activity | |
| testosterone 17-beta-dehydrogenase activity | |
| microsome |
| MedScan ID | 3293 |
|---|
| Hugo ID | 5212 |
|---|
| Human chromosome position | 9q22 |
|---|
| LocusLink ID | 3293 |
|---|---|
| 15487 | |
| 117182 |
| Alias | EDH17B3 |
|---|---|
| SDR12C2 | |
| RP11-240L7.3 | |
| testosterone 17-beta-dehydrogenase 3 | |
| 17-beta-HSD3 | |
| 17-beta-HSD 3 | |
| 17-beta-hydroxysteroid dehydrogenase type 3 | |
| testicular 17-beta-hydroxysteroid dehydrogenase | |
| short chain dehydrogenase/reductase family 12C, member 2 | |
| 17(beta)HSD type 3 | |
| estradiol 17 beta-dehydrogenase 3 | |
| 17-beta-hydroxysteroid dehydrogenase 3 | |
| 17-beta-hydroxysteroid dehydrogenase III | |
| Estradiol 17 beta-dehydrogenase III | |
| HSD17B3 | |
| hydroxysteroid (17-beta) dehydrogenase 3 | |
| hydroxysteroid (17-beta) dehydrogenase III | |
| OTTHUMP00000021718 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 605573 |
|---|---|
| 264300 |
| Mouse chromosome position | 13 |
|---|
| GO ID | 0004303 |
|---|---|
| 0016491 | |
| 0047045 | |
| 0030539 | |
| 0055114 | |
| 0006694 | |
| 0005792 | |
| 0003824 | |
| 0050327 | |
| 0008610 | |
| 0008152 | |
| 0005488 | |
| 0007530 | |
| 0005575 |
| Rat chromosome position | 17p14 |
|---|
| Swiss-Prot Accession | P37058 |
|---|---|
| Q6FH62 | |
| Q5U0Q6 | |
| P70385 | |
| O54939 |
| PIR ID | S43928 |
|---|
| Unigene ID | Hs.477 |
|---|---|
| Mm.5109 | |
| Rn.10895 |
| KEGG ID | hsa:3293 |
|---|---|
| mmu:15487 | |
| rno:117182 |
| EC Number | 1.1.1.64 |
|---|---|
| 1.1.1.62 |
| Swiss-Prot ID | DHB3_HUMAN |
|---|---|
| DHB3_RAT | |
| DHB3_MOUSE | |
| Q6FH62_HUMAN |
| Cell Localization | Mitochondria |
|---|
| IPI ID | IPI00019871 |
|---|---|
| IPI00199901 | |
| IPI00108329 | |
| IPI00844601 |
| Homologene ID | 20089 |
|---|
| RGD ID | 621805 |
|---|
| MGI ID | 107177 |
|---|