| URN | urn:agi-llid:5447 |
|---|---|
| Connectivity | 110 |
| Name | Por |
| Description | P450 (cytochrome) oxidoreductase |
| Notes | This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome. [provided by RefSeq] |
| Pathway | steroid hormone biosynthetic pathway |
|---|---|
| testosterone biosynthetic pathway - gth | |
| Copy of 'testosterone biosynthetic pathway' | |
| testosterone biosynthetic pathway | |
| estradiol biosynthetic pathway | |
| aldosterone biosynthetic pathway | |
| cortisol biosynthetic pathway | |
| Copy of 'steroid hormone biosynthetic pathway' | |
| Copy of 'steroid hormone biosynthetic pathway' | |
| Copy of 'steroid hormone biosynthetic pathway' | |
| testosterone biosynthetic pathway - Copy | |
| steroid hormone biosynthetic pathway | |
| estradiol biosynthetic pathway | |
| testosterone biosynthetic pathway |
| GO Molecular Function | oxidoreductase activity |
|---|---|
| FMN binding | |
| NADP or NADPH binding | |
| enzyme binding | |
| FAD binding | |
| iron ion binding | |
| NADPH-hemoprotein reductase activity |
| GO Cellular Component | membrane |
|---|---|
| soluble fraction | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| mitochondrion | |
| microsome |
| GO Biological Process | cellular metabolic process |
|---|---|
| oxidation reduction | |
| positive regulation of metabolic process | |
| nitric oxide catabolic process | |
| cellular response to peptide hormone stimulus | |
| regulation of cholesterol metabolic process | |
| positive regulation of monooxygenase activity |
| Ariadne Ontology | Steroid metabolism |
|---|
| Group | Steroid metabolism |
|---|---|
| cellular metabolic process | |
| oxidation reduction | |
| positive regulation of metabolic process | |
| nitric oxide catabolic process | |
| cellular response to peptide hormone stimulus | |
| regulation of cholesterol metabolic process | |
| positive regulation of monooxygenase activity | |
| oxidoreductase activity | |
| FMN binding | |
| NADP or NADPH binding | |
| enzyme binding | |
| FAD binding | |
| iron ion binding | |
| NADPH-hemoprotein reductase activity | |
| membrane | |
| soluble fraction | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| mitochondrion | |
| microsome |
| MedScan ID | 5447 |
|---|
| Hugo ID | 9208 |
|---|
| Human chromosome position | 7q11.2 |
|---|
| LocusLink ID | 5447 |
|---|---|
| 18984 | |
| 29441 |
| Alias | CPR |
|---|---|
| CYPOR | |
| P450R | |
| FLJ26468 | |
| DKFZp686G04235 | |
| NADPH--cytochrome P450 reductase | |
| OTTHUMP00000160964 | |
| OTTHUMP00000185560 | |
| OTTHUMP00000210071 | |
| NADPH-dependent cytochrome P450 reductase | |
| 4933424M13Rik | |
| OTTMUSP00000038029 | |
| NADH cytochrome P450 oxydoreductase | |
| cytochrome P450 reductase | |
| 4930447P04 | |
| 4930447P04Rik | |
| LOC96440 | |
| NAD(P)H-cytochrome P450 reductase | |
| NAD(P)H-dependent cytochrome p450 reductase | |
| NADP(H)-cytochrome P450 reductase | |
| NADP(H)-dependent cytochrome p450 reductase | |
| NADPH-cytochrome P450 reductase | |
| P450 (cytochrome) oxidoreductase | |
| Por | |
| CYP2C11 | |
| Cytochrome P-450 reductase | |
| RIKEN cDNA 4930447P04 gene |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 124015 |
|---|---|
| 201750 |
| Mouse chromosome position | 5 75.0 cM |
|---|
| GO ID | 0010181 |
|---|---|
| 0003958 | |
| 0005506 | |
| 0016491 | |
| 0044237 | |
| 0055114 | |
| 0032770 | |
| 0005783 | |
| 0005789 | |
| 0016020 | |
| 0050660 | |
| 0050661 | |
| 0019899 | |
| 0046210 | |
| 0090181 | |
| 0005792 | |
| 0005739 | |
| 0005625 | |
| 0071375 | |
| 0009893 | |
| 0009055 |
| Rat chromosome position | 12q12 |
|---|
| Swiss-Prot Accession | P16435 |
|---|---|
| Q59ED7 | |
| Q63HL4 | |
| Q9UDT3 | |
| P37040 | |
| Q05DV1 | |
| Q3V2F8 | |
| P00388 | |
| Q16455 | |
| Q197M5 | |
| Q8N181 | |
| Q9H3M8 |
| PIR ID | A36073 |
|---|---|
| A33421 |
| Unigene ID | Hs.354056 |
|---|---|
| Mm.3863 | |
| Rn.11359 |
| KEGG ID | hsa:5447 |
|---|---|
| mmu:18984 | |
| rno:29441 |
| EC Number | 1.6.2.4 |
|---|
| Swiss-Prot ID | NCPR_RAT |
|---|---|
| NCPR_MOUSE | |
| NCPR_HUMAN |
| Cell Localization | Endoplasmic reticulum membrane |
|---|---|
| Mitochondria |
| IPI ID | IPI00231200 |
|---|---|
| IPI00621548 | |
| IPI00470467 | |
| IPI00792395 | |
| IPI00852820 | |
| IPI00853510 | |
| IPI00852905 | |
| IPI00903331 | |
| IPI00880783 | |
| IPI00880279 | |
| IPI00881260 | |
| IPI00880597 |
| Homologene ID | 725 |
|---|
| RGD ID | 68335 |
|---|
| MGI ID | 97744 |
|---|