| URN | urn:agi-llid:3294 |
|---|---|
| Connectivity | 39 |
| Name | Hsd17b2 |
| Description | hydroxysteroid (17-beta) dehydrogenase 2 |
| Notes | 17-beta hydroxysteroid enzyme that regulates the biological activity of sex hormones, including estrogen and androgens [RGD] |
| Pathway | estradiol biosynthetic pathway |
|---|---|
| estradiol biosynthetic pathway | |
| testosterone biosynthetic pathway |
| GO Molecular Function | catalytic activity |
|---|---|
| oxidoreductase activity | |
| estradiol 17-beta-dehydrogenase activity | |
| 20-alpha-hydroxysteroid dehydrogenase activity | |
| testosterone 17-beta-dehydrogenase activity |
| GO Cellular Component | membrane |
|---|---|
| endoplasmic reticulum membrane | |
| integral to membrane |
| GO Biological Process | metabolic process |
|---|---|
| oxidation reduction | |
| response to retinoic acid | |
| lipid biosynthetic process | |
| steroid biosynthetic process |
| Ariadne Ontology | Steroid metabolism |
|---|
| Group | Steroid metabolism |
|---|---|
| catalytic activity | |
| metabolic process | |
| oxidation reduction | |
| response to retinoic acid | |
| lipid biosynthetic process | |
| steroid biosynthetic process | |
| oxidoreductase activity | |
| estradiol 17-beta-dehydrogenase activity | |
| 20-alpha-hydroxysteroid dehydrogenase activity | |
| testosterone 17-beta-dehydrogenase activity | |
| membrane | |
| endoplasmic reticulum membrane | |
| integral to membrane |
| MedScan ID | 3294 |
|---|
| Hugo ID | 5211 |
|---|
| Human chromosome position | 16q24.1-q24.2 |
|---|
| LocusLink ID | 3294 |
|---|---|
| 15486 | |
| 79243 |
| Alias | HSD17 |
|---|---|
| SDR9C2 | |
| EDH17B2 | |
| estradiol 17-beta-dehydrogenase 2 | |
| E2DH | |
| 20-alpha-HSD | |
| 17-beta-HSD 2 | |
| testosterone 17-beta-dehydrogenase | |
| 20 alpha-hydroxysteroid dehydrogenase | |
| 17-beta-hydroxysteroid dehydrogenase type 2 | |
| microsomal 17-beta-hydroxysteroid dehydrogenase | |
| short chain dehydrogenase/reductase family 9C, member 2 | |
| AI194836 | |
| AI194967 | |
| AI255511 | |
| 17 HSD type 2 | |
| 17-beta-hydroxysteroid dehydrogenase 2 | |
| 17-beta hydroxysteroid dehydrogenase type 2 | |
| 17 HSD 2 | |
| 17 HSD II | |
| 17-beta-HSD II | |
| 17-beta-hydroxysteroid dehydrogenase II | |
| Estradiol 17 beta-dehydrogenase 2 | |
| Estradiol 17 beta-dehydrogenase II | |
| HSD17B2 | |
| hydroxysteroid (17-beta) dehydrogenase 2 | |
| hydroxysteroid (17-beta) dehydrogenase II |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 109685 |
|---|
| Mouse chromosome position | 8 |
|---|
| GO ID | 0047006 |
|---|---|
| 0004303 | |
| 0016491 | |
| 0050327 | |
| 0055114 | |
| 0032526 | |
| 0006694 | |
| 0005789 | |
| 0016021 | |
| 0016020 | |
| 0003824 | |
| 0008610 | |
| 0008152 |
| Rat chromosome position | 19q12 |
|---|
| Swiss-Prot Accession | P37059 |
|---|---|
| Q53GD0 | |
| P51658 | |
| Q91X35 | |
| Q62730 | |
| Q5I0N4 | |
| B2R7T4 | |
| O08898 |
| PIR ID | A47287 |
|---|
| Unigene ID | Hs.162795 |
|---|---|
| Mm.276466 | |
| Rn.10515 |
| KEGG ID | hsa:3294 |
|---|---|
| mmu:15486 | |
| rno:79243 |
| EC Number | 1.1.1.63 |
|---|---|
| 1.1.1.62 |
| Swiss-Prot ID | DHB2_HUMAN |
|---|---|
| DHB2_MOUSE | |
| DHB2_RAT | |
| B2R7T4_HUMAN |
| Cell Localization | Membrane |
|---|---|
| Mitochondria |
| IPI ID | IPI00019872 |
|---|---|
| IPI00125076 | |
| IPI00208111 | |
| IPI00647420 |
| Homologene ID | 99709 |
|---|
| RGD ID | 621803 |
|---|
| MGI ID | 1096386 |
|---|