| URN | urn:agi-llid:6716 |
|---|---|
| Connectivity | 21 |
| Name | Srd5a2 |
| Description | steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) |
| Notes | This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH). [provided by RefSeq] |
| Pathway | testosterone biosynthetic pathway - gth |
|---|---|
| Copy of 'testosterone biosynthetic pathway' | |
| testosterone biosynthetic pathway | |
| testosterone biosynthetic pathway - Copy | |
| testosterone biosynthetic pathway |
| GO Molecular Function | oxidoreductase activity |
|---|---|
| oxidoreductase activity, acting on the CH-CH group of donors | |
| sterol 5-alpha reductase activity | |
| 3-oxo-5-alpha-steroid 4-dehydrogenase activity |
| GO Cellular Component | membrane |
|---|---|
| cytoplasm | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| microsome | |
| integral to membrane |
| GO Biological Process | oxidation reduction |
|---|---|
| cell-cell signaling | |
| cell differentiation | |
| sex differentiation | |
| male genitalia development | |
| male gonad development | |
| androgen metabolic process | |
| androgen biosynthetic process | |
| response to organic substance | |
| response to drug | |
| response to steroid hormone stimulus | |
| response to peptide hormone stimulus | |
| lipid metabolic process | |
| steroid metabolic process | |
| steroid catabolic process | |
| steroid biosynthetic process |
| Ariadne Ontology | Steroid metabolism |
|---|
| Group | Steroid metabolism |
|---|---|
| oxidation reduction | |
| cell-cell signaling | |
| cell differentiation | |
| sex differentiation | |
| male genitalia development | |
| male gonad development | |
| androgen metabolic process | |
| androgen biosynthetic process | |
| response to organic substance | |
| response to drug | |
| response to steroid hormone stimulus | |
| response to peptide hormone stimulus | |
| lipid metabolic process | |
| steroid metabolic process | |
| steroid catabolic process | |
| steroid biosynthetic process | |
| oxidoreductase activity | |
| oxidoreductase activity, acting on the CH-CH group of donors | |
| sterol 5-alpha reductase activity | |
| 3-oxo-5-alpha-steroid 4-dehydrogenase activity | |
| membrane | |
| cytoplasm | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| microsome | |
| integral to membrane |
| MedScan ID | 6716 |
|---|
| Hugo ID | 11285 |
|---|
| Human chromosome position | 2p23 |
|---|
| LocusLink ID | 6716 |
|---|---|
| 94224 | |
| 64677 |
| Alias | MGC138457 |
|---|---|
| 3-oxo-5-alpha-steroid 4-dehydrogenase 2 | |
| S5AR 2 | |
| SR type 2 | |
| 5 alpha-SR2 | |
| type II 5-alpha reductase | |
| steroid 5-alpha-reductase 2 | |
| 3-oxo-5 alpha-steroid 4-dehydrogenase 2 | |
| 5ART2 | |
| steroid 5 alpha reductase type2 | |
| 3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2 | |
| 3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha II | |
| 3-oxo-5-alpha-steroid 4-dehydrogenase II | |
| SR type II | |
| Srd5a2 | |
| Steroid 5-alpha- reductase II | |
| steroid-5-alpha-reductase, alpha polypeptide 2 | |
| steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) | |
| steroid-5-alpha-reductase, alpha polypeptide II | |
| steroid 5 alpha-reductase 2 | |
| Steroid 5-alpha- reductase 2 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 607306 |
|---|---|
| 264600 |
| Mouse chromosome position | 17 |
|---|---|
| 17 E2 |
| GO ID | 0003865 |
|---|---|
| 0009917 | |
| 0006702 | |
| 0008209 | |
| 0030154 | |
| 0007267 | |
| 0030539 | |
| 0008584 | |
| 0055114 | |
| 0042493 | |
| 0010033 | |
| 0043434 | |
| 0048545 | |
| 0007548 | |
| 0006706 | |
| 0005737 | |
| 0005783 | |
| 0005789 | |
| 0016021 | |
| 0016020 | |
| 0005792 | |
| 0016491 | |
| 0016627 | |
| 0006629 | |
| 0006694 | |
| 0008202 | |
| 0007530 | |
| 0005575 |
| Rat chromosome position | 6q13 |
|---|
| Swiss-Prot Accession | P31213 |
|---|---|
| Q99N99 | |
| Q99NA0 | |
| P31214 | |
| Q590M0 | |
| Q3UTZ9 | |
| B2RE87 | |
| Q2M1R4 | |
| Q9BYE6 |
| PIR ID | A44104 |
|---|---|
| A49169 |
| Unigene ID | Hs.458345 |
|---|---|
| Mm.38933 | |
| Rn.9938 |
| KEGG ID | hsa:6716 |
|---|---|
| mmu:94224 | |
| rno:64677 |
| EC Number | 1.3.99.5 |
|---|
| Swiss-Prot ID | S5A2_MOUSE |
|---|---|
| S5A2_RAT | |
| S5A2_HUMAN |
| Cell Localization | Microsome membrane |
|---|---|
| Endoplasmic reticulum membrane | |
| Mitochondria |
| IPI ID | IPI00118239 |
|---|---|
| IPI00210825 | |
| IPI00010651 |
| Homologene ID | 37292 |
|---|
| RGD ID | 621480 |
|---|
| MGI ID | 2150380 |
|---|