| URN | urn:agi-llid:1586 |
|---|---|
| Connectivity | 213 |
| Name | Cyp17a1 |
| Description | cytochrome P450, family 17, subfamily A, polypeptide 1 |
| Notes | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq] |
| Pathway | steroid hormone biosynthetic pathway |
|---|---|
| testosterone biosynthetic pathway - gth | |
| Copy of 'testosterone biosynthetic pathway' | |
| testosterone biosynthetic pathway | |
| estradiol biosynthetic pathway | |
| cortisol biosynthetic pathway | |
| Copy of 'steroid hormone biosynthetic pathway' | |
| Copy of 'steroid hormone biosynthetic pathway' | |
| Copy of 'steroid hormone biosynthetic pathway' | |
| testosterone biosynthetic pathway - Copy | |
| steroid hormone biosynthetic pathway | |
| estradiol biosynthetic pathway | |
| testosterone biosynthetic pathway |
| GO Molecular Function | electron carrier activity |
|---|---|
| oxygen binding | |
| oxidoreductase activity | |
| lyase activity | |
| heme binding | |
| metal ion binding | |
| iron ion binding | |
| monooxygenase activity | |
| steroid 17-alpha-monooxygenase activity |
| GO Cellular Component | membrane |
|---|---|
| neuronal cell body | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| mitochondrion | |
| axon |
| GO Biological Process | oxidation reduction |
|---|---|
| sex differentiation | |
| glucocorticoid biosynthetic process | |
| androgen biosynthetic process | |
| response to toxin | |
| response to organic cyclic substance | |
| response to retinoic acid | |
| steroid biosynthetic process |
| Ariadne Ontology | Steroid metabolism |
|---|
| Group | Steroid metabolism |
|---|---|
| electron carrier activity | |
| oxidation reduction | |
| sex differentiation | |
| glucocorticoid biosynthetic process | |
| androgen biosynthetic process | |
| response to toxin | |
| response to organic cyclic substance | |
| response to retinoic acid | |
| steroid biosynthetic process | |
| oxygen binding | |
| oxidoreductase activity | |
| lyase activity | |
| heme binding | |
| metal ion binding | |
| iron ion binding | |
| monooxygenase activity | |
| steroid 17-alpha-monooxygenase activity | |
| membrane | |
| neuronal cell body | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| mitochondrion | |
| axon |
| MedScan ID | 1586 |
|---|
| Hugo ID | 2593 |
|---|
| Human chromosome position | 10q24.3 |
|---|
| LocusLink ID | 1586 |
|---|---|
| 13074 | |
| 25146 |
| Alias | CPT7 |
|---|---|
| CYP17 | |
| S17AH | |
| P450C17 | |
| RP11-753C18.1 | |
| steroid 17-alpha-hydroxylase/17,20 lyase | |
| CYPXVII | |
| cytochrome P450c17 | |
| cytochrome P450-C17 | |
| cytochrome P450 17A1 | |
| cytochrome p450 XVIIA1 | |
| steroid 17-alpha-monooxygenase | |
| cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia | |
| OTTMUSP00000027151 | |
| cytochrome P450, 17 | |
| cytochrome P450, 17a1 | |
| steroid 17-alpha hydroxylase | |
| P450-C17 | |
| cytochrome P450, subfamily 17 | |
| Cytochrome P450, subfamily XVII | |
| 17 A1 | |
| Cyp17a I | |
| CYP17A1 | |
| CYPXVIIs | |
| cytochrome P450 17 | |
| cytochrome P450 17A | |
| cytochrome p450 XVIIA I | |
| cytochrome P45017 | |
| cytochrome P45017A1 | |
| cytochrome P450XVII | |
| cytochrome P450XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia | |
| OTTHUMP00000020382 | |
| P450 (CYP) 17A1 | |
| P450 17A1 | |
| P45017A1 | |
| Steroid 17,20 lyase | |
| steroid 17-alpha-hydroxylase | |
| cytochrome P450, family 17 | |
| cytochrome P450, family 17, subfamily a, polypeptide 1 | |
| cytochrome P450, family 17, subfamily A, polypeptide | |
| 17A1 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 609300 |
|---|---|
| 202110 |
| Mouse chromosome position | 19 46.0 cM |
|---|
| GO ID | 0009055 |
|---|---|
| 0020037 | |
| 0046872 | |
| 0004497 | |
| 0019825 | |
| 0004508 | |
| 0006704 | |
| 0055114 | |
| 0009636 | |
| 0007548 | |
| 0006694 | |
| 0030424 | |
| 0005783 | |
| 0005789 | |
| 0016020 | |
| 0005739 | |
| 0043025 | |
| 0005506 | |
| 0016829 | |
| 0016491 | |
| 0006702 | |
| 0014070 | |
| 0032526 | |
| 0006700 |
| Rat chromosome position | 1q55 |
|---|
| Swiss-Prot Accession | P05093 |
|---|---|
| Q1HB44 | |
| P27786 | |
| Q3UYU1 | |
| Q53YJ1 | |
| Q6P200 | |
| P11715 | |
| Q19P44 | |
| Q6LCX9 | |
| Q5TZV7 | |
| Q68FY2 | |
| Q6LAE5 |
| PIR ID | A40921 |
|---|---|
| A31359 | |
| A39072 |
| Unigene ID | Hs.438016 |
|---|---|
| Mm.1262 | |
| Rn.10172 |
| KEGG ID | hsa:1586 |
|---|---|
| mmu:13074 | |
| rno:25146 |
| EC Number | 1.14.99.9 |
|---|
| Swiss-Prot ID | CP17A_HUMAN |
|---|---|
| CP17A_RAT | |
| CP17A_MOUSE | |
| Q53YJ1_MOUSE | |
| Q1HB44_HUMAN | |
| Q3UYU1_MOUSE |
| Cell Localization | Membrane |
|---|---|
| Mitochondria |
| IPI ID | IPI00006665 |
|---|---|
| IPI00196701 | |
| IPI00119940 |
| Homologene ID | 73875 |
|---|
| RGD ID | 2456 |
|---|
| MGI ID | 88586 |
|---|