Protein Cyp11a1

URN	urn:agi-llid:1583
Connectivity	250
Name	Cyp11a1
Description	cytochrome P450, family 11, subfamily A, polypeptide 1
Notes	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide. [provided by RefSeq]

Pathway	steroid hormone biosynthetic pathway
	testosterone biosynthetic pathway - gth
	Copy of 'testosterone biosynthetic pathway'
	testosterone biosynthetic pathway
	estradiol biosynthetic pathway
	aldosterone biosynthetic pathway
	cortisol biosynthetic pathway
	Copy of 'steroid hormone biosynthetic pathway'
	Copy of 'steroid hormone biosynthetic pathway'
	Copy of 'steroid hormone biosynthetic pathway'
	testosterone biosynthetic pathway - Copy
	steroid hormone biosynthetic pathway
	estradiol biosynthetic pathway
	testosterone biosynthetic pathway

GO Molecular Function	electron carrier activity
	oxidoreductase activity
	heme binding
	cholesterol binding
	metal ion binding
	iron ion binding
	monooxygenase activity
	cholesterol monooxygenase (side-chain-cleaving) activity

GO Biological Process	oxidation reduction
	mating behavior
	cerebellum development
	granulosa cell differentiation
	C21-steroid hormone biosynthetic process
	response to organic substance
	response to nutrient
	response to cAMP
	response to hydrogen peroxide
	response to cadmium ion
	response to estrogen stimulus
	lipid metabolic process
	steroid metabolic process
	steroid biosynthetic process
	vitamin D metabolic process
	cholesterol metabolic process

Ariadne Ontology	Steroid metabolism

Group	Steroid metabolism
	electron carrier activity
	oxidation reduction
	mating behavior
	cerebellum development
	granulosa cell differentiation
	C21-steroid hormone biosynthetic process
	response to organic substance
	response to nutrient
	response to cAMP
	response to hydrogen peroxide
	response to cadmium ion
	response to estrogen stimulus
	lipid metabolic process
	steroid metabolic process
	steroid biosynthetic process
	vitamin D metabolic process
	cholesterol metabolic process
	oxidoreductase activity
	heme binding
	cholesterol binding
	metal ion binding
	iron ion binding
	monooxygenase activity
	cholesterol monooxygenase (side-chain-cleaving) activity
	membrane
	mitochondrion
	mitochondrial membrane
	mitochondrial crista

MedScan ID	1583

Hugo ID	2590

Human chromosome position	15q23-q24

Alias	CYP11A
	P450SCC
	cholesterol side-chain cleavage enzyme, mitochondrial
	CYPXIA1
	OTTHUMP00000198335
	steroid 20-22-lyase
	cytochrome P450 11A1
	cytochrome P450(scc)
	cytochrome P450C11A1
	cholesterol desmolase
	cholesterol 20-22 desmolase
	cholesterol monooxygenase (side-chain cleaving)
	cholesterol monooxygenase (side-chain-cleaving)
	cytochrome P450, subfamily XIA (cholesterol side chain cleavage)
	Scc
	cscc
	D9Ertd411e
	cholesterol side chain cleavage
	cytochrome P450 side-chain cleavage enzyme
	cytochrome P450, 11a, cholesterol side-chain cleavage
	P450(scc)
	cytochrome P450 subfamily 11A
	cholesterol side-chain cleavage cytochrome P450
	cytochrome P450 11a cholesterol side chain cleavage
	Cyp11a-1
	Cholesterol side-chain cleavage enzyme
	Cyp11a I
	Cyp11a1
	CYPXIA I
	cytochrome P450 11A1, mitochondrial
	cytochrome P450 side chain cleavage enzyme 11a I
	cytochrome P450 side chain cleavage enzyme 11a1
	cytochrome P450 subfamily 11A
	cytochrome P45011A
	cytochrome P450C11A I
	cytochrome P450XIA
	cytochrome P450XIA (cholesterol side chain cleavage)
	DNA segment, Chr 9, ERATO Doi 411, expressed
	P450 (CYP) 11A1
	P450 11A1
	P45011A1
	P450C11A1
	cytochrome P450, family 11, subfamily A, polypeptide 1
	Cholesterol desmolase
	cytochrome P450, 11a, cholesterol side chain cleavage
	Cytochrome P450 11A1, mitochondrial precursor
	cytochrome P450, subfamily XIA precursor
	cytochrome P450 11a cholesterol side
	cytochrome P450, subfamily 11A
	cytochrome P450, subfamily XIA

OMIM ID	118485
	201710

Mouse chromosome position	9 31.0 cM

Rat chromosome position	8q24

PIR ID	A34164
	A25922

EC Number	1.14.15.6

Cell Localization	Mitochondrion membrane
	Mitochondria

Homologene ID	37347

RGD ID	69325

MGI ID	88582