Ariadne Genomics Inc. Srd5a1 Srd5a2 Hsd17b2 Sts Sult2a1 e Cyp17a1 Por Fdx1 Fdxr e(3) Cyp11a1 cholesterol 17-hydroxypregnenolone ---> DHEA DHEA ---> DHEAS DHEAS ---> DHEA DHEA DHEAS DHEA ---> androstenediol Hsd17b3 NADP+ NADPH(3) ---> e(3) NADP+(3) NADPH(3) Star NADPH NADPH ---> e pregnenolone ---> 17-hydroxypregnenolone cholesterol ---> pregnenolone 17-hydroxypregnenolone androstenediol pregnenolone NADPH ---> NADP+ NADPH(3) ---> NADP+(3) Hsd3b2 Hsd3b1 testosterone ---> dihydrotestosterone DHEA ---> androstenedione androstenediol ---> testosterone testosterone androstenedione testosterone ---> androstenedione androstenedione ---> testosterone dihydrotestosterone