| URN | urn:agi-llid:2230 |
|---|---|
| Connectivity | 134 |
| Name | Fdx1 |
| Description | ferredoxin 1 |
| Notes | The product of this gene is a small iron-sulfur protein that transfers electrons from NADPH through ferredoxin reductase to a terminal cytochrome P450. This particular oxidation/reduction system is found in steroidogenic tissues, and is involved with the synthesis of bile acid and vitamin D. In addition to the expressed gene at this chromosomal locus (11q22), there are pseudogenes located on chromosomes 20 and 21. This gene product has been identified in a number of different tissues but all forms have been shown to be identical and are not tissue specific. [provided by RefSeq] |
| Pathway | steroid hormone biosynthetic pathway |
|---|---|
| testosterone biosynthetic pathway - gth | |
| Copy of 'testosterone biosynthetic pathway' | |
| testosterone biosynthetic pathway | |
| estradiol biosynthetic pathway | |
| aldosterone biosynthetic pathway | |
| cortisol biosynthetic pathway | |
| Copy of 'steroid hormone biosynthetic pathway' | |
| Copy of 'steroid hormone biosynthetic pathway' | |
| Copy of 'steroid hormone biosynthetic pathway' | |
| testosterone biosynthetic pathway - Copy |
| GO Molecular Function | electron carrier activity |
|---|---|
| enzyme binding | |
| iron-sulfur cluster binding | |
| metal ion binding | |
| iron ion binding | |
| 2 iron, 2 sulfur cluster binding |
| GO Cellular Component | mitochondrion |
|---|---|
| mitochondrial matrix |
| GO Biological Process | transport |
|---|---|
| generation of precursor metabolites and energy | |
| electron transport chain | |
| regulation of catalytic activity |
| Ariadne Ontology | Urea cycle |
|---|---|
| Steroid metabolism |
| Group | Urea cycle |
|---|---|
| Steroid metabolism | |
| electron carrier activity | |
| transport | |
| generation of precursor metabolites and energy | |
| electron transport chain | |
| regulation of catalytic activity | |
| enzyme binding | |
| iron-sulfur cluster binding | |
| metal ion binding | |
| iron ion binding | |
| 2 iron, 2 sulfur cluster binding | |
| mitochondrion | |
| mitochondrial matrix |
| MedScan ID | 2230 |
|---|
| Hugo ID | 3638 |
|---|
| Human chromosome position | 11q22 |
|---|
| LocusLink ID | 2230 |
|---|---|
| 14148 | |
| 29189 |
| Alias | ADX |
|---|---|
| FDX | |
| LOH11CR1D | |
| adrenodoxin, mitochondrial | |
| ferredoxin-1 | |
| hepatoredoxin | |
| adrenal ferredoxin | |
| mitochondrial adrenodoxin | |
| adrenodoxin | |
| CG4205-PA | |
| FDX I | |
| FDX1 | |
| ferredoxin | |
| ferredoxin 1 | |
| ferredoxin I | |
| Adrenodoxin, mitochondrial precursor |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 103260 |
|---|
| Mouse chromosome position | 9 |
|---|---|
| 9 B |
| GO ID | 0051537 |
|---|---|
| 0009055 | |
| 0005506 | |
| 0046872 | |
| 0022900 | |
| 0006091 | |
| 0006810 | |
| 0005759 | |
| 0005739 | |
| 0019899 | |
| 0051536 | |
| 0050790 |
| Rat chromosome position | 8q24 |
|---|
| Swiss-Prot Accession | P10109 |
|---|---|
| P46656 | |
| Q545P3 | |
| Q3UG56 | |
| Q4FZG2 | |
| P24483 | |
| Q2XTA9 | |
| B0YJ14 | |
| Q53YD6 |
| PIR ID | A39553 |
|---|---|
| A31853 | |
| S53524 |
| Unigene ID | Hs.744 |
|---|---|
| Mm.1061 | |
| Mm.440190 | |
| Rn.6946 |
| KEGG ID | hsa:2230 |
|---|---|
| mmu:14148 | |
| rno:29189 |
| Swiss-Prot ID | ADX_RAT |
|---|---|
| ADX_HUMAN | |
| ADX_MOUSE | |
| Q545P3_MOUSE |
| Cell Localization | Mitochondrion matrix |
|---|---|
| Mitochondria | |
| Cytoplasm |
| IPI ID | IPI00214587 |
|---|---|
| IPI00019326 | |
| IPI00135939 | |
| IPI00653472 |
| Homologene ID | 31216 |
|---|
| RGD ID | 62036 |
|---|
| MGI ID | 103224 |
|---|