| URN | urn:agi-llid:1584 |
|---|---|
| Connectivity | 49 |
| Name | Cyp11b1 |
| Description | cytochrome P450, family 11, subfamily B, polypeptide 1 |
| Notes | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq] |
| Pathway | aldosterone biosynthetic pathway |
|---|---|
| cortisol biosynthetic pathway |
| GO Molecular Function | electron carrier activity |
|---|---|
| oxidoreductase activity | |
| steroid binding | |
| heme binding | |
| metal ion binding | |
| monooxygenase activity | |
| steroid hydroxylase activity | |
| steroid 11-beta-monooxygenase activity | |
| corticosterone 18-monooxygenase activity |
| GO Cellular Component | membrane |
|---|---|
| mitochondrion | |
| mitochondrial inner membrane | |
| mitochondrial membrane | |
| integral to endoplasmic reticulum membrane |
| GO Biological Process | immune response |
|---|---|
| oxidation reduction | |
| response to stress | |
| regulation of blood volume by renal aldosterone | |
| regulation of systemic arterial blood pressure by circulatory renin-angiotensin | |
| glucocorticoid metabolic process | |
| glucocorticoid biosynthetic process | |
| C21-steroid hormone biosynthetic process | |
| cortisol biosynthetic process | |
| aldosterone biosynthetic process | |
| drinking behavior | |
| steroid metabolic process | |
| steroid biosynthetic process | |
| regulation of blood pressure | |
| ion homeostasis | |
| glucose homeostasis |
| Ariadne Ontology | Steroid metabolism |
|---|
| Group | Steroid metabolism |
|---|---|
| electron carrier activity | |
| immune response | |
| oxidation reduction | |
| response to stress | |
| regulation of blood volume by renal aldosterone | |
| regulation of systemic arterial blood pressure by circulatory renin-angiotensin | |
| glucocorticoid metabolic process | |
| glucocorticoid biosynthetic process | |
| C21-steroid hormone biosynthetic process | |
| cortisol biosynthetic process | |
| aldosterone biosynthetic process | |
| drinking behavior | |
| steroid metabolic process | |
| steroid biosynthetic process | |
| regulation of blood pressure | |
| ion homeostasis | |
| glucose homeostasis | |
| oxidoreductase activity | |
| steroid binding | |
| heme binding | |
| metal ion binding | |
| monooxygenase activity | |
| steroid hydroxylase activity | |
| steroid 11-beta-monooxygenase activity | |
| corticosterone 18-monooxygenase activity | |
| membrane | |
| mitochondrion | |
| mitochondrial inner membrane | |
| mitochondrial membrane | |
| integral to endoplasmic reticulum membrane |
| MedScan ID | 1584 |
|---|
| Hugo ID | 2591 |
|---|
| Human chromosome position | 8q21 |
|---|
| LocusLink ID | 1584 |
|---|---|
| 110115 | |
| 353498 | |
| 500892 |
| Alias | FHI |
|---|---|
| CPN1 | |
| CYP11B | |
| P450C11 | |
| FLJ36771 | |
| DKFZp686B05283 | |
| cytochrome P450 11B1, mitochondrial | |
| CYPXIB1 | |
| cytochrome P450C11 | |
| cytochrome P-450c11 | |
| cytochrome p450 XIB1 | |
| steroid 11-beta-hydroxylase | |
| steroid 11-beta-monooxygenase | |
| cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 1 | |
| AA389061 | |
| Cyp11b-1 | |
| cytochrome P450, family 11, subfamily b, polypeptide 1 | |
| steroid-11-beta-hydroxylase | |
| CYPXIB3 | |
| cytochrome P450, family 11, subfamily b, polypeptide 3 | |
| cytochrome P450, subfamily 11B, polypeptide 3 | |
| Cp11ba | |
| RATCP11BA | |
| P450(11 beta)-DS | |
| aldosterone synthase | |
| cytochrome P450(11 beta)-DS | |
| cytochrome P450, subfamily 11B, polypeptide 1 | |
| Cytochrome P450, subfamily XIB, polypeptide 1 (steroid 11-beta-hydroxylase) | |
| S11BH | |
| CYP11B3 | |
| Cp450b | |
| Cyp11b I | |
| CYP11B1 | |
| CYPXIB I | |
| cytochrome P450 11B | |
| cytochrome P450 11B1 | |
| cytochrome P450 11B3 | |
| cytochrome p450 XIB I | |
| cytochrome P45011B III | |
| cytochrome P45011B1 | |
| cytochrome P45011B3 | |
| cytochrome P450XIB (steroid 11-beta-hydroxylase) | |
| cytochrome P450XIB steroid 11-beta-hydroxylase 1 | |
| cytochrome P450XIB steroid 11-beta-hydroxylase I | |
| cytochrome P450XIB1 (steroid 11-beta-hydroxylase) | |
| LOC362932 | |
| LOC362933 | |
| P450 (CYP) 11B1 | |
| P450 (CYP) 11B3 | |
| P450 11B1 | |
| P450 11B3 | |
| P45011B1 | |
| P45011B3 | |
| RNCP450B | |
| steroid 11-beta-monooxygenase 1 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 610613 |
|---|---|
| 202010 | |
| 103900 |
| Mouse chromosome position | 15 44.9 cM |
|---|
| GO ID | 0009055 |
|---|---|
| 0020037 | |
| 0046872 | |
| 0004497 | |
| 0004507 | |
| 0006700 | |
| 0032342 | |
| 0034651 | |
| 0042593 | |
| 0006955 | |
| 0055114 | |
| 0008217 | |
| 0006950 | |
| 0006694 | |
| 0016020 | |
| 0005743 | |
| 0005739 | |
| 0047783 | |
| 0016491 | |
| 0005496 | |
| 0006704 | |
| 0030176 | |
| 0008395 | |
| 0042756 | |
| 0050801 | |
| 0002017 | |
| 0001991 | |
| 0008202 | |
| 0031966 | |
| 0008211 |
| Rat chromosome position | 7q34 |
|---|
| Swiss-Prot Accession | P15538 |
|---|---|
| Q8TDD0 | |
| Q4VAQ9 | |
| Q4VAR0 | |
| Q8N9P8 | |
| Q8TE38 | |
| Q8TE39 | |
| Q8TE40 | |
| Q3TG86 | |
| Q3TR45 | |
| Q3UQH5 | |
| Q64539 | |
| Q64546 | |
| Q64586 | |
| P15393 | |
| Q64655 | |
| Q14095 | |
| Q4VAQ8 | |
| Q9UML2 |
| PIR ID | A46039 |
|---|---|
| S11338 |
| Unigene ID | Hs.184927 |
|---|---|
| Mm.322606 | |
| Rn.198236 | |
| Rn.198235 |
| KEGG ID | hsa:1584 |
|---|---|
| mmu:110115 | |
| rno:353498 | |
| rno:500892 |
| EC Number | 1.14.15.4 |
|---|
| Swiss-Prot ID | C11B1_RAT |
|---|---|
| C11B1_HUMAN | |
| Q8TDD0_HUMAN | |
| Q64539_RAT | |
| Q3UQH5_MOUSE | |
| Q4VAQ9_HUMAN | |
| Q3TG86_MOUSE |
| Cell Localization | Mitochondrion membrane |
|---|---|
| Mitochondria |
| IPI ID | IPI00734638 |
|---|---|
| IPI00291348 | |
| IPI00213646 | |
| IPI00351582 | |
| IPI00167781 | |
| IPI00607879 | |
| IPI00797881 | |
| IPI00205747 | |
| IPI00767607 |
| RGD ID | 727886 |
|---|---|
| 2453 |
| MGI ID | 88583 |
|---|