| URN | urn:agi-llid:1585 |
|---|---|
| Connectivity | 122 |
| Name | Cyp11b2 |
| Description | cytochrome P450, family 11, subfamily B, polypeptide 2 |
| Notes | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency. [provided by RefSeq] |
| Pathway | aldosterone biosynthetic pathway |
|---|
| GO Molecular Function | electron carrier activity |
|---|---|
| oxidoreductase activity | |
| heme binding | |
| metal ion binding | |
| iron ion binding | |
| monooxygenase activity | |
| steroid 11-beta-monooxygenase activity | |
| corticosterone 18-monooxygenase activity |
| GO Cellular Component | membrane |
|---|---|
| mitochondrion | |
| mitochondrial inner membrane | |
| mitochondrial membrane | |
| dendrite |
| GO Biological Process | oxidation reduction |
|---|---|
| renal water homeostasis | |
| regulation of blood volume by renal aldosterone | |
| regulation of systemic arterial blood pressure by circulatory renin-angiotensin | |
| C21-steroid hormone biosynthetic process | |
| cortisol biosynthetic process | |
| aldosterone biosynthetic process | |
| response to drug | |
| response to peptide hormone stimulus | |
| response to insulin stimulus | |
| response to salt stress | |
| drinking behavior | |
| steroid biosynthetic process | |
| positive regulation of blood pressure | |
| ion homeostasis | |
| potassium ion homeostasis | |
| sodium ion homeostasis |
| Ariadne Ontology | Steroid metabolism |
|---|
| Group | Steroid metabolism |
|---|---|
| electron carrier activity | |
| oxidation reduction | |
| renal water homeostasis | |
| regulation of blood volume by renal aldosterone | |
| regulation of systemic arterial blood pressure by circulatory renin-angiotensin | |
| C21-steroid hormone biosynthetic process | |
| cortisol biosynthetic process | |
| aldosterone biosynthetic process | |
| response to drug | |
| response to peptide hormone stimulus | |
| response to insulin stimulus | |
| response to salt stress | |
| drinking behavior | |
| steroid biosynthetic process | |
| positive regulation of blood pressure | |
| ion homeostasis | |
| potassium ion homeostasis | |
| sodium ion homeostasis | |
| oxidoreductase activity | |
| heme binding | |
| metal ion binding | |
| iron ion binding | |
| monooxygenase activity | |
| steroid 11-beta-monooxygenase activity | |
| corticosterone 18-monooxygenase activity | |
| membrane | |
| mitochondrion | |
| mitochondrial inner membrane | |
| mitochondrial membrane | |
| dendrite |
| MedScan ID | 1585 |
|---|
| Hugo ID | 2592 |
|---|
| Human chromosome position | 8q21-q22 |
|---|
| LocusLink ID | 1585 |
|---|---|
| 13072 | |
| 24294 |
| Alias | CPN2 |
|---|---|
| ALDOS | |
| CYP11B | |
| CYP11BL | |
| P450C18 | |
| P-450C18 | |
| P450aldo | |
| cytochrome P450 11B2, mitochondrial | |
| CYPXIB2 | |
| cytochrome P-450C18 | |
| aldosterone synthase | |
| cytochrome P-450Aldo | |
| steroid 11-beta-monooxygenase | |
| steroid 11-beta/18-hydroxylase | |
| aldosterone-synthesizing enzyme | |
| steroid 18-hydroxylase, aldosterone synthase, P450C18, P450aldo | |
| mitochondrial cytochrome P450, family 11, subfamily B, polypeptide 2 | |
| cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2 | |
| Cyp11b-2 | |
| MGC151285 | |
| cytochrome P450C11 | |
| steroid 11-beta-hydroxylase | |
| steroid-11-beta-hydroxylase | |
| Cp45as | |
| Cyp11b3 | |
| RNCP45AS | |
| CYPXIB3 | |
| P450-Aldo-1 | |
| P450-Aldo-2 | |
| cytochrome P450-Aldo-1 | |
| cytochrome P450-Aldo-2 | |
| cytochrome P450 11B3, mitochondrial | |
| cytochrome P450, subfamily 11B, polypeptide 2 | |
| Cytochrome P450 subfamily XIB polypeptide 2 (aldosterone synthase) | |
| Cytochrome P450, subfamily XIB, polypeptide 2 (aldosterone synthase) | |
| aldosterone synthetase | |
| CYP11B2 | |
| Cyp11b2 sup m1 /sup | |
| Cyp11b2<sup>m1</sup> | |
| cytochrome P450 11B II | |
| cytochrome P450 11B2 | |
| cytochrome P450 XIB 2 (aldosterone synthase) | |
| cytochrome P450 XIB 2 (aldosterone synthetase) | |
| cytochrome P450, subfamily 11B, polypeptide 2, mutation 1 | |
| cytochrome P45011B2 | |
| cytochrome P45011B2, mutation 1 | |
| cytochrome P450XIB | |
| cytochrome P450XIB 2 | |
| cytochrome P450XIB steroid 11-beta-hydroxylase 2 | |
| mitochondrial Cytochrome P450 11B2 | |
| P450 (CYP) 11B2 | |
| P450 11B2 | |
| P45011B2 | |
| steroid 11-beta-monooxygenase 2 | |
| steroid 11-beta-monooxygenase II | |
| Steroid 18-hydroxylase | |
| steroid 18-hydroxylase, aldosterone synthetase, P450C18, P450aldo |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 124080 |
|---|---|
| 203400 | |
| 610600 |
| Mouse chromosome position | 15 44.9 cM |
|---|
| GO ID | 0047783 |
|---|---|
| 0009055 | |
| 0020037 | |
| 0046872 | |
| 0004497 | |
| 0004507 | |
| 0006700 | |
| 0032342 | |
| 0034651 | |
| 0055114 | |
| 0055075 | |
| 0002017 | |
| 0003091 | |
| 0055078 | |
| 0006694 | |
| 0016020 | |
| 0005743 | |
| 0005739 | |
| 0005506 | |
| 0016491 | |
| 0042756 | |
| 0050801 | |
| 0045777 | |
| 0001991 | |
| 0030425 | |
| 0042493 | |
| 0032868 | |
| 0043434 | |
| 0009651 | |
| 0031966 |
| Rat chromosome position | 7q34 |
|---|
| Swiss-Prot Accession | P19099 |
|---|---|
| Q14098 | |
| Q16315 | |
| Q16316 | |
| Q14AB5 | |
| P15539 | |
| P30099 | |
| P30100 | |
| B0ZBE4 | |
| Q16726 |
| PIR ID | B34181 |
|---|
| Unigene ID | Hs.632054 |
|---|---|
| Mm.377079 | |
| Rn.144549 |
| KEGG ID | hsa:1585 |
|---|---|
| mmu:13072 | |
| rno:24294 |
| EC Number | 1.14.15.5 |
|---|---|
| 1.14.15.4 |
| Swiss-Prot ID | C11B2_HUMAN |
|---|---|
| Q14AB5_MOUSE | |
| B0ZBE4_HUMAN |
| Cell Localization | Mitochondrion membrane |
|---|---|
| Mitochondria |
| IPI ID | IPI00290116 |
|---|---|
| IPI00776050 | |
| IPI00816253 | |
| IPI00323713 | |
| IPI00205063 |
| Homologene ID | 106948 |
|---|
| RGD ID | 2454 |
|---|
| MGI ID | 88584 |
|---|