| URN | urn:agi-llid:6770 |
|---|---|
| Connectivity | 339 |
| Name | Star |
| Description | steroidogenic acute regulatory protein |
| Notes | The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13. [provided by RefSeq] |
| Pathway | steroid hormone biosynthetic pathway |
|---|---|
| testosterone biosynthetic pathway - gth | |
| Copy of 'testosterone biosynthetic pathway' | |
| testosterone biosynthetic pathway | |
| estradiol biosynthetic pathway | |
| aldosterone biosynthetic pathway | |
| cortisol biosynthetic pathway | |
| Copy of 'steroid hormone biosynthetic pathway' | |
| Copy of 'steroid hormone biosynthetic pathway' | |
| Copy of 'steroid hormone biosynthetic pathway' | |
| testosterone biosynthetic pathway - Copy |
| GO Molecular Function | lipid binding |
|---|---|
| cholesterol binding | |
| cholesterol transporter activity |
| GO Cellular Component | cytosol |
|---|---|
| mitochondrion | |
| mitochondrial intermembrane space |
| GO Biological Process | transport |
|---|---|
| positive regulation of anti-apoptosis | |
| brain development | |
| positive regulation of neurogenesis | |
| regulation of neuronal synaptic plasticity | |
| cellular lipid metabolic process | |
| glucocorticoid metabolic process | |
| bile acid biosynthetic process | |
| cellular response to insulin stimulus | |
| response to drug | |
| response to nutrient | |
| response to organic cyclic substance | |
| response to ethanol | |
| response to hydrogen peroxide | |
| response to lead ion | |
| response to peptide hormone stimulus | |
| regulation of steroid biosynthetic process | |
| steroid biosynthetic process | |
| lipid transport |
| Group | transport |
|---|---|
| positive regulation of anti-apoptosis | |
| brain development | |
| positive regulation of neurogenesis | |
| regulation of neuronal synaptic plasticity | |
| cellular lipid metabolic process | |
| glucocorticoid metabolic process | |
| bile acid biosynthetic process | |
| cellular response to insulin stimulus | |
| response to drug | |
| response to nutrient | |
| response to organic cyclic substance | |
| response to ethanol | |
| response to hydrogen peroxide | |
| response to lead ion | |
| response to peptide hormone stimulus | |
| regulation of steroid biosynthetic process | |
| steroid biosynthetic process | |
| lipid transport | |
| lipid binding | |
| cholesterol binding | |
| cholesterol transporter activity | |
| cytosol | |
| mitochondrion | |
| mitochondrial intermembrane space |
| MedScan ID | 6770 |
|---|
| Hugo ID | 11359 |
|---|
| Human chromosome position | 8p11.2 |
|---|
| LocusLink ID | 6770 |
|---|---|
| 20845 | |
| 25557 |
| Alias | STARD1 |
|---|---|
| steroidogenic acute regulatory protein, mitochondrial | |
| cholesterol trafficker | |
| START domain containing 1 | |
| steroidogenic acute regulator | |
| steroid acute regulatory protein | |
| START domain-containing protein 1 | |
| mitochondrial steroid acute regulatory protein | |
| StAR-related lipid transfer (START) domain containing 1 | |
| AV363654 | |
| D8Ertd419e | |
| luteinizing hormone-induced protein | |
| DNA segment, Chr 8, ERATO Doi 419, expressed | |
| STAR | |
| STARD I | |
| START domain containing I | |
| steroidogenic acute regulatory protein | |
| STARD1s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 600617 |
|---|---|
| 201710 |
| Mouse chromosome position | 8 9.0 cM |
|---|
| GO ID | 0015485 |
|---|---|
| 0017127 | |
| 0008289 | |
| 0006699 | |
| 0007420 | |
| 0044255 | |
| 0032869 | |
| 0008211 | |
| 0006869 | |
| 0045768 | |
| 0050769 | |
| 0048168 | |
| 0050810 | |
| 0042493 | |
| 0045471 | |
| 0042542 | |
| 0010288 | |
| 0007584 | |
| 0014070 | |
| 0043434 | |
| 0006694 | |
| 0005829 | |
| 0005758 | |
| 0005739 | |
| 0006810 | |
| 0005515 | |
| 0006700 |
| Rat chromosome position | 16q12.4 |
|---|
| Swiss-Prot Accession | P49675 |
|---|---|
| Q6IBK0 | |
| Q306J4 | |
| Q3LR71 | |
| Q3LR72 | |
| Q6QNJ9 | |
| P51557 | |
| Q6P910 | |
| P97826 | |
| Q5XUN6 | |
| P97628 | |
| Q543A5 | |
| Q924Y5 | |
| Q9D2G1 | |
| Q16396 |
| PIR ID | A55455 |
|---|---|
| I38248 |
| Unigene ID | Hs.521535 |
|---|---|
| Mm.293314 | |
| Rn.11399 |
| KEGG ID | hsa:6770 |
|---|---|
| mmu:20845 | |
| rno:25557 |
| Swiss-Prot ID | STAR_RAT |
|---|---|
| STAR_MOUSE | |
| STAR_HUMAN | |
| Q6IBK0_HUMAN |
| Cell Localization | Mitochondrion |
|---|
| IPI ID | IPI00208600 |
|---|---|
| IPI00311822 | |
| IPI00027730 | |
| IPI00514337 | |
| IPI00621597 |
| Homologene ID | 297 |
|---|
| RGD ID | 3770 |
|---|
| MGI ID | 102760 |
|---|