| URN | urn:agi-llid:8720 |
|---|---|
| Connectivity | 41 |
| Name | Mbtps1 |
| Description | membrane-bound transcription factor peptidase, site 1 |
| Notes | The encoded protein has a central role in the regulation of lipid metabolism in cells. It is a sterol-regulated subtilisin-like serine protease that cleaves ER membrane-bound sterol regulatory element-binding proteins (SREBPs), a reaction that initiates the two-step proteolytic process by which transcriptionally active fragments of SREBPs are released from the membrane for translocation to the nucleus. The gene product is an integral membrane ER protein, with the bulk located in the ER lumen. It is synthesized as an inactive preproprotein that is self-activated by an intramolecular cleavage that generates the mature protein. |
| Pathway | sterol regulatory element-binding protein signaling pathway |
|---|
| GO Molecular Function | hydrolase activity |
|---|---|
| calcium ion binding | |
| peptidase activity | |
| serine-type peptidase activity | |
| endopeptidase activity | |
| serine-type endopeptidase activity |
| GO Cellular Component | membrane |
|---|---|
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| Golgi apparatus | |
| endoplasmic reticulum lumen | |
| Golgi membrane | |
| Golgi stack | |
| nucleus | |
| integral to membrane |
| GO Biological Process | regulation of transcription factor import into nucleus |
|---|---|
| lipid metabolic process | |
| proteolysis | |
| steroid metabolic process | |
| cholesterol metabolic process |
| Group | regulation of transcription factor import into nucleus |
|---|---|
| lipid metabolic process | |
| proteolysis | |
| steroid metabolic process | |
| cholesterol metabolic process | |
| hydrolase activity | |
| calcium ion binding | |
| peptidase activity | |
| serine-type peptidase activity | |
| endopeptidase activity | |
| serine-type endopeptidase activity | |
| membrane | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| Golgi apparatus | |
| endoplasmic reticulum lumen | |
| Golgi membrane | |
| Golgi stack | |
| nucleus | |
| integral to membrane |
| MedScan ID | 8720 |
|---|
| Hugo ID | 15456 |
|---|
| Human chromosome position | 16 |
|---|
| LocusLink ID | 8720 |
|---|---|
| 56453 | |
| 89842 |
| Alias | S1P |
|---|---|
| PCSK8 | |
| SKI-1 | |
| KIAA0091 | |
| MGC138711 | |
| MGC138712 | |
| membrane-bound transcription factor site-1 protease | |
| site-1 protease | |
| endopeptidase S1P | |
| subtilisin/kexin isozyme-1 | |
| subtilisin/kexin-isozyme 1 | |
| membrane-bound transcription factor protease, site 1 | |
| Ski1 | |
| AV003995 | |
| mKIAA0091 | |
| 0610038M03Rik | |
| S1P endopeptidase | |
| subtilisin/kexin isozyme 1 | |
| subtilisin/kexin isozyme SKI-1 | |
| sterol-regulated luminal protease | |
| 0610038M03 | |
| Mbtps I | |
| Mbtps1 | |
| membrane-bound transcription factor peptidase, site 1 | |
| membrane-bound transcription factor protease | |
| membrane-bound transcription factor protease, site I | |
| SKI I | |
| site-1 protease preproprotein | |
| subtilisin/kexin isozyme-1 preproprotein | |
| RIKEN cDNA 0610038M03 gene | |
| Mbtps1s | |
| expressed sequence AV003995 | |
| Mbtps Is |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 603355 |
|---|
| Mouse chromosome position | 8 |
|---|---|
| 8 E1 |
| GO ID | 0008233 |
|---|---|
| 0004252 | |
| 0008203 | |
| 0006508 | |
| 0042990 | |
| 0008202 | |
| 0005794 | |
| 0000139 | |
| 0005795 | |
| 0005783 | |
| 0005788 | |
| 0005789 | |
| 0016021 | |
| 0016020 | |
| 0005634 | |
| 0004175 | |
| 0016787 | |
| 0008236 | |
| 0006629 | |
| 0005509 | |
| 0005737 | |
| 0004289 | |
| 0005615 |
| Rat chromosome position | 19q12 |
|---|
| Swiss-Prot Accession | Q14703 |
|---|---|
| Q9WTZ2 | |
| Q3TP75 | |
| Q3UHA7 | |
| Q80U80 | |
| Q9CW89 | |
| Q9WTZ3 | |
| Q6PG67 | |
| Q24JQ2 | |
| Q9UF67 |
| PIR ID | T43492 |
|---|
| Unigene ID | Hs.75890 |
|---|---|
| Mm.206934 | |
| Rn.2362 |
| KEGG ID | hsa:8720 |
|---|---|
| mmu:56453 | |
| rno:89842 |
| EC Number | 3.4.21.112 |
|---|
| Swiss-Prot ID | MBTP1_MOUSE |
|---|---|
| MBTP1_HUMAN | |
| MBTP1_RAT |
| Cell Localization | Endoplasmic reticulum membrane |
|---|---|
| Golgi apparatus membrane |
| IPI ID | IPI00124157 |
|---|---|
| IPI00021569 | |
| IPI00203510 | |
| IPI00397466 | |
| IPI00473288 |
| Homologene ID | 2808 |
|---|
| RGD ID | 70935 |
|---|
| MGI ID | 1927235 |
|---|