| URN | urn:agi-llid:22937 |
|---|---|
| Connectivity | 61 |
| Name | Scap |
| Description | SREBF chaperone |
| Notes | This gene encodes a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis. |
| Pathway | sterol regulatory element-binding protein signaling pathway |
|---|
| GO Molecular Function | protein complex binding |
|---|---|
| unfolded protein binding | |
| cholesterol binding |
| GO Cellular Component | protein complex |
|---|---|
| membrane | |
| endoplasmic reticulum membrane | |
| cytoplasmic vesicle | |
| endoplasmic reticulum | |
| Golgi apparatus | |
| Golgi membrane | |
| ER to Golgi transport vesicle membrane | |
| microsome | |
| integral to membrane |
| GO Biological Process | aging |
|---|---|
| regulation of fatty acid metabolic process | |
| regulation of fatty acid biosynthetic process | |
| positive regulation of low-density lipoprotein receptor biosynthetic process | |
| positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway | |
| response to hypoxia | |
| response to insulin stimulus | |
| negative regulation of cholesterol biosynthetic process | |
| regulation of cholesterol biosynthetic process | |
| lipid metabolic process | |
| steroid metabolic process | |
| cholesterol metabolic process |
| Ariadne Ontology | ER to Golgi transport |
|---|
| Group | ER to Golgi transport |
|---|---|
| aging | |
| regulation of fatty acid metabolic process | |
| regulation of fatty acid biosynthetic process | |
| positive regulation of low-density lipoprotein receptor biosynthetic process | |
| positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway | |
| response to hypoxia | |
| response to insulin stimulus | |
| negative regulation of cholesterol biosynthetic process | |
| regulation of cholesterol biosynthetic process | |
| lipid metabolic process | |
| steroid metabolic process | |
| cholesterol metabolic process | |
| protein complex binding | |
| unfolded protein binding | |
| cholesterol binding | |
| protein complex | |
| membrane | |
| endoplasmic reticulum membrane | |
| cytoplasmic vesicle | |
| endoplasmic reticulum | |
| Golgi apparatus | |
| Golgi membrane | |
| ER to Golgi transport vesicle membrane | |
| microsome | |
| integral to membrane |
| MedScan ID | 22937 |
|---|
| Hugo ID | 30634 |
|---|
| Human chromosome position | 3p21.31 |
|---|
| LocusLink ID | 22937 |
|---|---|
| 235623 | |
| 301024 |
| Alias | KIAA0199 |
|---|---|
| PSEC0227 | |
| sterol regulatory element-binding protein cleavage-activating protein | |
| SREBP cleavage-activating protein | |
| sterol regulatory element binding protein cleavage-activating protein | |
| mKIAA0199 | |
| 9530044G19 | |
| OTTMUSP00000027712 | |
| Sreb cleavage-activating protein | |
| SREBP cleavage activating protein | |
| Scap | |
| SREBF chaperone | |
| SREBF chaperone protein | |
| hypothetical protein 9530044G19 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 601510 |
|---|
| Mouse chromosome position | 9 58.0 cM |
|---|---|
| 9 F2 |
| GO ID | 0032403 |
|---|---|
| 0051082 | |
| 0007568 | |
| 0008203 | |
| 0045541 | |
| 0045716 | |
| 0006994 | |
| 0042304 | |
| 0001666 | |
| 0032868 | |
| 0008202 | |
| 0012507 | |
| 0005794 | |
| 0000139 | |
| 0031410 | |
| 0005783 | |
| 0005789 | |
| 0016021 | |
| 0016020 | |
| 0005792 | |
| 0043234 | |
| 0015485 | |
| 0006629 | |
| 0045540 | |
| 0019217 | |
| 0005515 |
| Rat chromosome position | 8q32 |
|---|
| Swiss-Prot Accession | Q12770 |
|---|---|
| Q6PIX8 | |
| Q6GQT6 | |
| A2RRU4 | |
| Q8N2E0 | |
| Q8WUA1 | |
| Q6A0A6 | |
| Q6NS67 | |
| Q7TNG7 | |
| Q80UI6 |
| Unigene ID | Hs.531789 |
|---|---|
| Mm.288741 | |
| Rn.99548 |
| KEGG ID | hsa:22937 |
|---|---|
| mmu:235623 | |
| rno:301024 |
| Swiss-Prot ID | SCAP_HUMAN |
|---|---|
| SCAP_RAT | |
| SCAP_MOUSE |
| Cell Localization | Endoplasmic reticulum membrane |
|---|---|
| Golgi apparatus membrane | |
| Cytoplasmic vesicle | |
| COPII-coated vesicle membrane | |
| Endoplasmic reticulum |
| IPI ID | IPI00006280 |
|---|---|
| IPI00290700 | |
| IPI00290701 | |
| IPI00396357 | |
| IPI00373570 | |
| IPI00856221 | |
| IPI00448910 | |
| IPI00790533 | |
| IPI00792550 | |
| IPI00791253 | |
| IPI00856929 | |
| IPI00415905 | |
| IPI00857276 | |
| IPI00856733 |
| Homologene ID | 8160 |
|---|
| RGD ID | 1309378 |
|---|
| MGI ID | 2135958 |
|---|