| URN | urn:agi-llid:51141 |
|---|---|
| Connectivity | 37 |
| Name | Insig2 |
| Description | insulin induced gene 2 |
| Notes | The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. |
| Pathway | sterol regulatory element-binding protein signaling pathway |
|---|
| GO Molecular Function | transcription factor binding |
|---|
| GO Cellular Component | membrane |
|---|---|
| SREBP-SCAP-Insig complex | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| integral to membrane |
| GO Biological Process | palate development |
|---|---|
| cranial suture morphogenesis | |
| middle ear morphogenesis | |
| inner ear morphogenesis | |
| negative regulation of fatty acid biosynthetic process | |
| triglyceride metabolic process | |
| ER-nuclear sterol response pathway | |
| response to sterol depletion | |
| response to lipid | |
| response to fatty acid | |
| response to insulin stimulus | |
| negative regulation of steroid biosynthetic process | |
| lipid metabolic process | |
| steroid metabolic process | |
| sterol biosynthetic process | |
| cholesterol biosynthetic process | |
| cholesterol metabolic process |
| Group | palate development |
|---|---|
| cranial suture morphogenesis | |
| middle ear morphogenesis | |
| inner ear morphogenesis | |
| negative regulation of fatty acid biosynthetic process | |
| triglyceride metabolic process | |
| ER-nuclear sterol response pathway | |
| response to sterol depletion | |
| response to lipid | |
| response to fatty acid | |
| response to insulin stimulus | |
| negative regulation of steroid biosynthetic process | |
| lipid metabolic process | |
| steroid metabolic process | |
| sterol biosynthetic process | |
| cholesterol biosynthetic process | |
| cholesterol metabolic process | |
| transcription factor binding | |
| membrane | |
| SREBP-SCAP-Insig complex | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| integral to membrane |
| MedScan ID | 51141 |
|---|
| Hugo ID | 20452 |
|---|
| Human chromosome position | 2q14.2 |
|---|---|
| 2q14.1 |
| LocusLink ID | 51141 |
|---|---|
| 72999 | |
| 288985 |
| Alias | MGC26273 |
|---|---|
| insulin-induced gene 2 protein | |
| INSIG-2 | |
| INSIG2 membrane protein | |
| insulin induced protein 2 | |
| 2900053I11Rik | |
| C730043J18Rik | |
| INSIG-2 membrane protein | |
| 2900053I11 | |
| C730043J18 | |
| growth response protein (CL-6) | |
| INSIG2 | |
| insulin induced gene 2 | |
| insulin induced gene II | |
| LOC129941 | |
| LOC150813 | |
| LOC51141 | |
| LOC64194 | |
| RIKEN cDNA C730043J18 gene | |
| INSIG2s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 608660 |
|---|
| Mouse chromosome position | 1 |
|---|---|
| 1 E2 |
| GO ID | 0030967 |
|---|---|
| 0008203 | |
| 0008202 | |
| 0032937 | |
| 0005783 | |
| 0005789 | |
| 0016021 | |
| 0016020 | |
| 0008134 | |
| 0006695 | |
| 0060363 | |
| 0042472 | |
| 0006629 | |
| 0042474 | |
| 0045717 | |
| 0010894 | |
| 0060021 | |
| 0006991 | |
| 0016126 | |
| 0006641 | |
| 0070542 | |
| 0032868 | |
| 0033993 | |
| 0005515 |
| Rat chromosome position | 13q11 |
|---|
| Swiss-Prot Accession | Q9Y5U4 |
|---|---|
| Q91WG1 | |
| Q80UA9 | |
| Q3TMY2 | |
| Q8BWP1 | |
| A8K5W8 | |
| Q8TBI8 |
| Unigene ID | Hs.7089 |
|---|---|
| Mm.27136 | |
| Rn.16736 |
| KEGG ID | hsa:51141 |
|---|---|
| mmu:72999 | |
| rno:288985 |
| Swiss-Prot ID | INSI2_MOUSE |
|---|---|
| INSI2_RAT | |
| INSI2_HUMAN | |
| A8K5W8_HUMAN |
| Cell Localization | Endoplasmic reticulum membrane |
|---|
| IPI ID | IPI00459467 |
|---|---|
| IPI00287193 | |
| IPI00001794 | |
| IPI00413159 |
| Homologene ID | 9400 |
|---|
| RGD ID | 631417 |
|---|
| MGI ID | 1920249 |
|---|