| URN | urn:agi-llid:6721 |
|---|---|
| Connectivity | 204 |
| Name | Srebf2 |
| Description | sterol regulatory element binding factor 2 (predicted) |
| Notes | This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain. |
| Pathway | InsulinR -> ELK-SRF/SREBF signaling |
|---|---|
| FibronectinR -> AP-1/ELK-SRF/SREBF signaling | |
| sterol regulatory element-binding protein signaling pathway |
| GO Molecular Function | transcription regulator activity |
|---|---|
| chromatin binding | |
| transcription factor activity | |
| RNA polymerase II transcription factor activity | |
| protein C-terminus binding | |
| DNA binding | |
| sequence-specific DNA binding | |
| C-8 sterol isomerase activity | |
| specific RNA polymerase II transcription factor activity |
| GO Cellular Component | membrane |
|---|---|
| cytoplasm | |
| SREBP-SCAP-Insig complex | |
| endoplasmic reticulum membrane | |
| cytoplasmic vesicle | |
| endoplasmic reticulum | |
| Golgi apparatus | |
| Golgi membrane | |
| ER to Golgi transport vesicle membrane | |
| nucleus | |
| microsome | |
| integral to membrane | |
| dendrite |
| GO Biological Process | aging |
|---|---|
| spermatogenesis | |
| regulation of transcription | |
| positive regulation of transcription | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of transcription via sterol regulatory element binding | |
| transcription | |
| response to drug | |
| response to hormone stimulus | |
| response to lipid | |
| response to lead ion | |
| lipid metabolic process | |
| lipid biosynthetic process | |
| steroid metabolic process | |
| cholesterol metabolic process |
| Ariadne Ontology | Ubiquitous bHLH-ZIP factors |
|---|
| Group | Ubiquitous bHLH-ZIP factors |
|---|---|
| transcription regulator activity | |
| aging | |
| spermatogenesis | |
| regulation of transcription | |
| positive regulation of transcription | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of transcription via sterol regulatory element binding | |
| transcription | |
| response to drug | |
| response to hormone stimulus | |
| response to lipid | |
| response to lead ion | |
| lipid metabolic process | |
| lipid biosynthetic process | |
| steroid metabolic process | |
| cholesterol metabolic process | |
| chromatin binding | |
| transcription factor activity | |
| RNA polymerase II transcription factor activity | |
| protein C-terminus binding | |
| DNA binding | |
| sequence-specific DNA binding | |
| C-8 sterol isomerase activity | |
| specific RNA polymerase II transcription factor activity | |
| membrane | |
| cytoplasm | |
| SREBP-SCAP-Insig complex | |
| endoplasmic reticulum membrane | |
| cytoplasmic vesicle | |
| endoplasmic reticulum | |
| Golgi apparatus | |
| Golgi membrane | |
| ER to Golgi transport vesicle membrane | |
| nucleus | |
| microsome | |
| integral to membrane | |
| dendrite |
| MedScan ID | 6721 |
|---|
| Hugo ID | 11290 |
|---|
| Human chromosome position | 22q13 |
|---|
| LocusLink ID | 6721 |
|---|---|
| 20788 | |
| 300095 |
| Alias | SREBP2 |
|---|---|
| bHLHd2 | |
| CTA-250D10.14 | |
| sterol regulatory element-binding protein 2 | |
| SREBP-2 | |
| class D basic helix-loop-helix protein 2 | |
| sterol regulatory element-binding transcription factor 2 | |
| AI608257 | |
| SREBP2gc | |
| MGC124823 | |
| Srebf2_retired | |
| sterol regulatory element binding factor 2 | |
| sterol regulatory element binding protein 2 | |
| OTTHUMP00000028740 | |
| SRE binding protein II | |
| SRE binding protein-2 | |
| SRE binding transcription factor 2 | |
| SRE binding transcription factor II | |
| SRE2 | |
| SRE2_HUMAN | |
| SREBF2 | |
| SRE-binding factor 2 | |
| SRE-binding factor II | |
| sterol regulatory element binding factor II | |
| Sterol regulatory element binding protein II | |
| sterol regulatory element binding transcription factor 2 | |
| sterol regulatory element binding transcription factor II | |
| sterol response element binding protein 2 | |
| sterol response element binding protein-2 | |
| sterol response element binding protein-II | |
| sterol response element-binding protein 2 | |
| sterol response element-binding protein II | |
| sterol response element-binding protein-2 | |
| Sterol regulatory element binding protein-2 | |
| Srebf2s | |
| SREBP2s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 600481 |
|---|
| Mouse chromosome position | 15 |
|---|---|
| 15 E1 |
| GO ID | 0000247 |
|---|---|
| 0003702 | |
| 0003682 | |
| 0008022 | |
| 0043565 | |
| 0003704 | |
| 0003700 | |
| 0007568 | |
| 0008203 | |
| 0006629 | |
| 0045941 | |
| 0045944 | |
| 0035104 | |
| 0042493 | |
| 0009725 | |
| 0010288 | |
| 0033993 | |
| 0007283 | |
| 0008202 | |
| 0012507 | |
| 0005794 | |
| 0000139 | |
| 0032937 | |
| 0005737 | |
| 0031410 | |
| 0030425 | |
| 0005783 | |
| 0005789 | |
| 0016021 | |
| 0016020 | |
| 0005792 | |
| 0005634 | |
| 0003677 | |
| 0030528 | |
| 0045449 | |
| 0006350 | |
| 0008610 | |
| 0005515 | |
| 0006357 | |
| 0006355 |
| Rat chromosome position | 7q34 |
|---|
| Swiss-Prot Accession | Q12772 |
|---|---|
| Q8NCY3 | |
| Q05BD5 | |
| Q3U1N2 | |
| Q8BPL7 | |
| Q3T1I5 | |
| Q925C2 | |
| Q9ESZ4 | |
| Q6GTH7 | |
| Q86V36 | |
| Q9UH04 | |
| Q8N8F0 |
| PIR ID | A49397 |
|---|
| Unigene ID | Hs.443258 |
|---|---|
| Mm.38016 | |
| Rn.41063 | |
| Mm.397809 |
| KEGG ID | hsa:6721 |
|---|---|
| mmu:20788 | |
| rno:300095 |
| Swiss-Prot ID | SRBP2_MOUSE |
|---|---|
| SRBP2_RAT | |
| SRBP2_HUMAN | |
| Q8NCY3_HUMAN |
| Cell Localization | Endoplasmic reticulum membrane |
|---|---|
| Golgi apparatus membrane | |
| Cytoplasmic vesicle | |
| COPII-coated vesicle membrane | |
| Nucleus |
| IPI ID | IPI00474598 |
|---|---|
| IPI00761225 | |
| IPI00366445 | |
| IPI00328793 | |
| IPI00794281 | |
| IPI00889623 | |
| IPI00780070 |
| Homologene ID | 20966 |
|---|
| RGD ID | 1307751 |
|---|
| MGI ID | 107585 |
|---|