| URN | urn:agi-llid:3638 |
|---|---|
| Connectivity | 56 |
| Name | Insig1 |
| Description | insulin induced gene 1 |
| Notes | Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) mediated signaling pathway. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed. |
| Pathway | sterol regulatory element-binding protein signaling pathway |
|---|
| GO Cellular Component | membrane |
|---|---|
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| integral to membrane |
| GO Biological Process | metabolic process |
|---|---|
| cell proliferation | |
| palate development | |
| cranial suture morphogenesis | |
| negative regulation of fat cell differentiation | |
| middle ear morphogenesis | |
| inner ear morphogenesis | |
| negative regulation of fatty acid biosynthetic process | |
| triglyceride metabolic process | |
| cellular response to insulin stimulus | |
| ER-nuclear sterol response pathway | |
| response to sterol depletion | |
| response to lipid | |
| response to peptide hormone stimulus | |
| response to fatty acid | |
| response to estradiol stimulus | |
| negative regulation of steroid biosynthetic process | |
| lipid metabolic process | |
| steroid metabolic process | |
| sterol biosynthetic process | |
| cholesterol biosynthetic process | |
| cholesterol metabolic process |
| Group | metabolic process |
|---|---|
| cell proliferation | |
| palate development | |
| cranial suture morphogenesis | |
| negative regulation of fat cell differentiation | |
| middle ear morphogenesis | |
| inner ear morphogenesis | |
| negative regulation of fatty acid biosynthetic process | |
| triglyceride metabolic process | |
| cellular response to insulin stimulus | |
| ER-nuclear sterol response pathway | |
| response to sterol depletion | |
| response to lipid | |
| response to peptide hormone stimulus | |
| response to fatty acid | |
| response to estradiol stimulus | |
| negative regulation of steroid biosynthetic process | |
| lipid metabolic process | |
| steroid metabolic process | |
| sterol biosynthetic process | |
| cholesterol biosynthetic process | |
| cholesterol metabolic process | |
| membrane | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| integral to membrane |
| MedScan ID | 3638 |
|---|
| Hugo ID | 6083 |
|---|
| Human chromosome position | 7q36 |
|---|
| LocusLink ID | 3638 |
|---|---|
| 231070 | |
| 64194 |
| Alias | CL6 |
|---|---|
| CL-6 | |
| MGC1405 | |
| insulin-induced gene 1 protein | |
| OTTHUMP00000216471 | |
| INSIG-1 membrane protein | |
| Insig-1 | |
| 1810013C12Rik | |
| immediate-early protein CL-6 | |
| growth response protein (CL-6) | |
| insulin-induced growth response protein CL-6 | |
| 1810013C12 | |
| CL VI | |
| INSIG I | |
| INSIG1 | |
| insulin induced gene 1 | |
| insulin induced gene I | |
| RIKEN cDNA 1810013C12 | |
| RIKEN cDNA 1810013C12 gene | |
| INSIG1s | |
| INSIG Is |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 602055 |
|---|
| Mouse chromosome position | 5 |
|---|---|
| 5 B1 |
| GO ID | 0030967 |
|---|---|
| 0008283 | |
| 0008203 | |
| 0008152 | |
| 0008202 | |
| 0005783 | |
| 0005789 | |
| 0016021 | |
| 0016020 | |
| 0006695 | |
| 0060363 | |
| 0042472 | |
| 0006629 | |
| 0042474 | |
| 0045599 | |
| 0045717 | |
| 0010894 | |
| 0060021 | |
| 0006991 | |
| 0016126 | |
| 0006641 | |
| 0032869 | |
| 0032355 | |
| 0070542 | |
| 0033993 | |
| 0043434 | |
| 0005515 |
| Rat chromosome position | 4q11 |
|---|
| Swiss-Prot Accession | O15503 |
|---|---|
| A4D2N1 | |
| Q8BGI3 | |
| Q08755 | |
| A8K6L0 | |
| Q53XW8 | |
| Q9BUV5 | |
| A2RSM6 | |
| Q3UAX9 | |
| Q3UX30 | |
| A4D2M9 |
| PIR ID | A47112 |
|---|
| Unigene ID | Hs.520819 |
|---|---|
| Mm.30221 | |
| Rn.772 |
| KEGG ID | hsa:3638 |
|---|---|
| mmu:231070 | |
| rno:64194 |
| Swiss-Prot ID | INSI1_RAT |
|---|---|
| INSI1_HUMAN | |
| INSI1_MOUSE | |
| A4D2N1_HUMAN | |
| A4D2M9_HUMAN | |
| A8K6L0_HUMAN |
| Cell Localization | Endoplasmic reticulum membrane |
|---|
| IPI ID | IPI00203668 |
|---|---|
| IPI00290111 | |
| IPI00221619 | |
| IPI00383584 | |
| IPI00383583 | |
| IPI00892597 |
| Homologene ID | 4047 |
|---|
| RGD ID | 708457 |
|---|
| MGI ID | 1916289 |
|---|