Ariadne Genomics Inc. translocated Srebf cholesterol Srebf targets translocated Srebf ---> fatty acid biosynthetic pathway translocated Srebf ---> cholesterol biosynthetic pathway translocated Srebf ---> Srebf targets 25-Hydroxycholesterol ---> Srebf at Golgi cholesterol ---- Scap Scap ---> Srebf at Golgi Srebf1 ---> Srebf at Golgi Srebf2 ---> Srebf at Golgi cholesterol ---> Srebf at Golgi Scap ---- Srebf1 Scap ---- Srebf2 25-Hydroxycholesterol ---- Insig2 Insig2 ---- Scap Mbtps1 ---> Srebf at Golgi Mbtps2 ---> Srebf at Golgi Mbtps1 Mbtps2 Srebf at Golgi 25-Hydroxycholesterol Insig1 Insig2 Scap Srebf2 Srebf1 fatty acid biosynthetic pathway cholesterol biosynthetic pathway Srebf at Golgi ---> translocated Srebf