| URN | urn:agi-llid:788 |
|---|---|
| Connectivity | 24 |
| Name | Slc25a20 |
| Description | solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 |
| Notes | The protein encoded by this gene is located at the mitochondrial inner membrane where it transfers fatty acylcarnitines into mitochondria. Thus it is critical in the fatty acid oxidation process. A defect in this translocase impairs oxidation of fatty acids and can cause a varieties of pathological conditions such as hypoglycemia, cardiac arrest, hepatomegaly, hepatic dysfunction and muscle weakness. |
| Pathway | fatty acid beta degradation pathway |
|---|
| GO Molecular Function | transporter activity |
|---|---|
| acyl carnitine transporter activity |
| GO Cellular Component | membrane |
|---|---|
| mitochondrion | |
| mitochondrial inner membrane | |
| integral to membrane |
| GO Biological Process | transmembrane transport |
|---|---|
| transport | |
| regulation of fatty acid oxidation | |
| carnitine shuttle |
| Ariadne Ontology | Fatty acid oxidation |
|---|---|
| Lipid transport |
| Group | Fatty acid oxidation |
|---|---|
| Lipid transport | |
| transporter activity | |
| transmembrane transport | |
| transport | |
| regulation of fatty acid oxidation | |
| carnitine shuttle | |
| acyl carnitine transporter activity | |
| membrane | |
| mitochondrion | |
| mitochondrial inner membrane | |
| integral to membrane |
| MedScan ID | 788 |
|---|
| Hugo ID | 1421 |
|---|
| Human chromosome position | 3p21.31 |
|---|
| LocusLink ID | 788 |
|---|---|
| 57279 | |
| 117035 |
| Alias | CAC |
|---|---|
| CACT | |
| mitochondrial carnitine/acylcarnitine carrier protein | |
| OTTHUMP00000210385 | |
| solute carrier family 25 member 20 | |
| carnitine/acylcarnitine translocase | |
| carnitine/acylcarnitine carrier protein | |
| mCAC | |
| C78826 | |
| 1110007P09Rik | |
| mitochondrial carnitine-acylcarnitine translocase | |
| MGC93269 | |
| solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20 | |
| 1110007P09 | |
| carnitine-acylcarnitine carrier | |
| Slc25a20 | |
| solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 | |
| Carnitine-acylcarnitine translocase | |
| RIKEN cDNA 1110007P09 gene | |
| mitochondrial carnitine-acylcarnitine translocase gene |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 212138 |
|---|
| Mouse chromosome position | 9 |
|---|---|
| 9 F2 |
| GO ID | 0015227 |
|---|---|
| 0005215 | |
| 0006853 | |
| 0046320 | |
| 0055085 | |
| 0016021 | |
| 0016020 | |
| 0005743 | |
| 0005739 | |
| 0006810 | |
| 0005488 | |
| 0005319 | |
| 0019866 |
| Rat chromosome position | 8q32 |
|---|
| Swiss-Prot Accession | O43772 |
|---|---|
| Q9Z2Z6 | |
| Q7TPW6 | |
| Q66HP8 | |
| P97521 | |
| Q3U801 | |
| B2R7F4 | |
| Q9UIQ2 |
| Unigene ID | Hs.13845 |
|---|---|
| Mm.29666 | |
| Rn.3289 |
| KEGG ID | hsa:788 |
|---|---|
| mmu:57279 | |
| rno:117035 |
| Swiss-Prot ID | MCAT_MOUSE |
|---|---|
| MCAT_HUMAN | |
| Q66HP8_RAT |
| Cell Localization | Mitochondrion inner membrane |
|---|---|
| Mitochondria | |
| Plasma membrane |
| IPI ID | IPI00131584 |
|---|---|
| IPI00013957 | |
| IPI00471905 | |
| IPI00205413 |
| Homologene ID | 331 |
|---|
| RGD ID | 621443 |
|---|
| MGI ID | 1928738 |
|---|